1995
Nitric oxide synthase inhibition and extracellular glutamate concentration after cerebral ischemia/reperfusion.
Zhang J, Benveniste H, Klitzman B, Piantadosi C. Nitric oxide synthase inhibition and extracellular glutamate concentration after cerebral ischemia/reperfusion. Stroke 1995, 26: 298-304. PMID: 7530389, DOI: 10.1161/01.str.26.2.298.Peer-Reviewed Original ResearchConceptsIschemia/reperfusionBlood-brain barrierCerebral blood flowBrain ischemia/reperfusionExcitatory amino acidsExtracellular glutamate concentrationL-NAMEBlood flowGlutamate concentrationSynthase inhibitionL-arginineExcitatory amino acid toxicityL-NAME-treated ratsPostischemic cerebral blood flowNitric oxide synthase inhibitionCerebral ischemia/reperfusionBlood-brain barrier functionL-arginine methyl esterCerebral blood flow responseBlood-brain barrier permeabilityGlobal brain ischemia/reperfusionElevated glutamate concentrationsImmediate postischemic periodInterstitial glutamate concentrationL-NAME administration
1993
Microdialysis measurements of PGD2, TXB2 and 6-keto-PGF1α in rat CA1 hippocampus during transient cerebral ischemia
Huttemeier P, Kamiyama Y, Su M, Watkins W, Benveniste H. Microdialysis measurements of PGD2, TXB2 and 6-keto-PGF1α in rat CA1 hippocampus during transient cerebral ischemia. Prostaglandins 1993, 45: 177-187. PMID: 8430228, DOI: 10.1016/0090-6980(93)90033-4.Peer-Reviewed Original ResearchMeSH Keywords6-Ketoprostaglandin F1 alphaAnimalsArachidonic AcidDialysisHippocampusIschemic Attack, TransientKineticsMaleProstaglandin D2RatsRats, Sprague-DawleyThromboxane B2ConceptsCerebral ischemiaPGF1 alphaMicrodialysis probeRat CA1 hippocampusGlobal cerebral ischemiaTransient cerebral ischemiaRole of PGD2Arachidonic acid metabolismAverage peak concentrationDistinct brain regionsIschemic brainEicosanoid concentrationsCA1 hippocampusEicosanoid releaseAA metabolitesPG metabolitesMicrodialysis measurementsBaseline levelsBrain regionsIschemiaPGD2TXB2Implanted microdialysis probesPeak concentrationAcid metabolism
1988
Calcium accumulation by glutamate receptor activation is involved in hippocampal cell damage after ischemia
Benveniste H, Jørgensen M, Diemer N, Hansen A. Calcium accumulation by glutamate receptor activation is involved in hippocampal cell damage after ischemia. Acta Neurologica Scandinavica 1988, 78: 529-536. PMID: 2906199, DOI: 10.1111/j.1600-0404.1988.tb03697.x.Peer-Reviewed Original ResearchConceptsGlutamate N-methyl-D-aspartate receptorN-methyl-D-aspartate receptorsCell damageNerve cell destructionComplete cerebral ischemiaBrain cell damageMin of ischemiaOnset of ischemiaHippocampal cell damageGlutamate receptor activationCA 1 regionRole of intracellularCerebral ischemiaIschemic periodBilateral destructionDenervated hippocampusAfferent inputSynaptic transmissionCalcium influxIschemiaCompetitive antagonistReceptor activationHistological studyCell destructionCalcium accumulation
1985
Cellular Origin of Ischemia‐Induced Glutamate Release from Brain Tissue In Vivo and In Vitro
Drejer J, Benveniste H, Diemer N, Schousboe A. Cellular Origin of Ischemia‐Induced Glutamate Release from Brain Tissue In Vivo and In Vitro. Journal Of Neurochemistry 1985, 45: 145-151. PMID: 2860206, DOI: 10.1111/j.1471-4159.1985.tb05486.x.Peer-Reviewed Original ResearchConceptsPotassium-induced releaseGlutamatergic neuronsAspartate uptakeConditions of hypoglycemiaCultured glutamatergic neuronsTransient cerebral ischemiaHigh potassiumExtracellular glutamate contentCerebral ischemiaGlutamate releaseTransmitter poolExtracellular glutamateMicrodialysis techniqueIschemiaBrain tissuePotassium stimulationPerfusion mediumHypoglycemiaGlutamate contentNeuronsInduced increasesCellular originVivo experimentsAstrocytesPrevious reports
1984
Elevation of the Extracellular Concentrations of Glutamate and Aspartate in Rat Hippocampus During Transient Cerebral Ischemia Monitored by Intracerebral Microdialysis
Benveniste H, Drejer J, Schousboe A, Diemer N. Elevation of the Extracellular Concentrations of Glutamate and Aspartate in Rat Hippocampus During Transient Cerebral Ischemia Monitored by Intracerebral Microdialysis. Journal Of Neurochemistry 1984, 43: 1369-1374. PMID: 6149259, DOI: 10.1111/j.1471-4159.1984.tb05396.x.Peer-Reviewed Original ResearchMeSH KeywordsAmino AcidsAnimalsAspartic AcidBlood-Brain BarrierDialysisExtracellular SpaceGlutamatesGlutamic AcidHippocampusIschemic Attack, TransientMaleRatsRats, Inbred StrainsConceptsGamma-aminobutyric acidCerebral ischemiaIschemic periodTransient complete cerebral ischemiaTransient cerebral ischemiaComplete cerebral ischemiaExtracellular contentAmino acid glutamateDiameter dialysisIntracerebral microdialysisConcentrations of alanineExtracellular glutamateRat hippocampusCertain neuronsTaurine concentrationsIschemiaExtracellular concentrationHippocampusExtracellular fluidRinger's solutionGlutamateSame periodAspartateCausal factorsPeriod