2023
Platelet response to influenza vaccination reflects effects of aging
Konstorum A, Mohanty S, Zhao Y, Melillo A, Vander Wyk B, Nelson A, Tsang S, Blevins T, Belshe R, Chawla D, Rondina M, Gill T, Montgomery R, Allore H, Kleinstein S, Shaw A. Platelet response to influenza vaccination reflects effects of aging. Aging Cell 2023, 22: e13749. PMID: 36656789, PMCID: PMC9924941, DOI: 10.1111/acel.13749.Peer-Reviewed Original ResearchConceptsCommunity-dwelling older adultsPlatelet activationOlder adultsInfluenza vaccinationAge-associated chronic inflammationInfluence platelet functionRNA expressionPro-inflammatory diseasesAge-associated increasePlatelet activation pathwaysAge-associated differencesActivation pathwayPlatelet transcriptomeGeriatric conditionsChronic inflammationImmune responsePlatelet functionPlatelet responseSNF residentsVaccinationActivation responseYoung individualsProtein levelsAdultsYounger participants
2014
Innate Immune Responses in the Neutrophils of Community Dwelling and Nursing Home Elders
Juthani-Mehta M, Guo X, Shaw AC, Towle V, Ning Y, Wang X, Allore HG, Fikrig E, Montgomery RR. Innate Immune Responses in the Neutrophils of Community Dwelling and Nursing Home Elders. Journal Of Aging Science 2014, 02 PMID: 25750929, PMCID: PMC4348001, DOI: 10.4172/2329-8847.1000115.Peer-Reviewed Original ResearchNursing home residentsΒ2-integrin expressionToll-like receptorsHome residentsInnate immune responseImmune responseIntegrin CD11bDisabled nursing home residentsIntegrin expressionΒ2 integrin CD11bLevels of chemokinesObservational pilot studyArea nursing homesNursing home eldersLocomotion of neutrophilsTLR4 responseChemokine inductionInfectious disease susceptibilityCommunity dwellingCommunity dwellersNursing homesEfficiency of neutrophilsNeutrophilsUnstimulated neutrophilsFlow cytometry