2021
Out‐of‐pocket Annual Health Expenditures and Financial Toxicity from Healthcare Costs in Patients with Heart Failure in the United States
Wang SY, Valero‐Elizondo J, Ali H, Pandey A, Cainzos‐Achirica M, Krumholz HM, Nasir K, Khera R. Out‐of‐pocket Annual Health Expenditures and Financial Toxicity from Healthcare Costs in Patients with Heart Failure in the United States. Journal Of The American Heart Association 2021, 10: e022164. PMID: 33998273, PMCID: PMC8483501, DOI: 10.1161/jaha.121.022164.Peer-Reviewed Original ResearchConceptsGreater risk-adjusted oddsRisk-adjusted oddsHeart failureMedical Expenditure Panel SurveyCatastrophic financial burdenPocket healthcare expensesHigh financial burdenFinancial toxicityHealthcare expensesFinancial burdenHealthcare costsCatastrophic burdenMajor public health burdenLow-income familiesBackground Heart failurePublic health burdenInsurance premiumsPanel SurveyPocket healthcare costsAnnual health expenditureWorld Health OrganizationConclusions PatientsHealth insurance premiumsPocket healthcare expenditureHealth burden
2020
Evaluation of a Risk Stratification Model Using Preoperative and Intraoperative Data for Major Morbidity or Mortality After Cardiac Surgical Treatment
Durant TJS, Jean RA, Huang C, Coppi A, Schulz WL, Geirsson A, Krumholz HM. Evaluation of a Risk Stratification Model Using Preoperative and Intraoperative Data for Major Morbidity or Mortality After Cardiac Surgical Treatment. JAMA Network Open 2020, 3: e2028361. PMID: 33284333, DOI: 10.1001/jamanetworkopen.2020.28361.Peer-Reviewed Original Research
2019
Usefulness of Social Support in Older Adults After Hospitalization for Acute Myocardial Infarction (from the SILVER-AMI Study)
Green YS, Hajduk AM, Song X, Krumholz HM, Sinha SK, Chaudhry SI. Usefulness of Social Support in Older Adults After Hospitalization for Acute Myocardial Infarction (from the SILVER-AMI Study). The American Journal Of Cardiology 2019, 125: 313-319. PMID: 31787249, PMCID: PMC7003680, DOI: 10.1016/j.amjcard.2019.10.038.Peer-Reviewed Original ResearchConceptsAcute myocardial infarctionPost-AMI outcomesMyocardial infarctionIndependent associationMedical Outcomes Study Social Support SurveySocial supportOlder AMI patientsSocial Support SurveyParticipants 75 yearsLow emotional supportLow social supportImportant social determinantInitial hospitalizationOlder patientsDevelopment of interventionsAMI patientsMultivariable analysisMean ageMultivariable regressionHealth outcomesSupport SurveyInformational supportReadmissionSocial determinantsOlder adults
2018
Large-Scale Epidemiologic Studies of Cardiovascular Diseases in China Need for Improved Data Collection, Methods, Transparency, and Documentation
Qu H, Lu Y, Gudbranson E, Bucholz EM, Xuan S, Masoudi FA, Spertus JA, Zheng X, Li J, Krumholz HM. Large-Scale Epidemiologic Studies of Cardiovascular Diseases in China Need for Improved Data Collection, Methods, Transparency, and Documentation. Global Heart 2018, 13: 3-12.e4. PMID: 29248362, DOI: 10.1016/j.gheart.2017.07.002.Peer-Reviewed Original Research
2017
Perspectives from NHLBI Global Health Think Tank Meeting for Late Stage (T4) Translation Research
Engelgau MM, Peprah E, Sampson UKA, Mishoe H, Benjamin IJ, Douglas PS, Hochman JS, Ridker PM, Brandes N, Checkley W, El-Saharty S, Ezzati M, Hennis A, Jiang L, Krumholz HM, Lamourelle G, Makani J, Narayan KMV, Ohene-Frempong K, Straus SE, Stuckler D, Chambers DA, Belis D, Bennett GC, Boyington JE, Creazzo TL, de Jesus JM, Krishnamurti C, Lowden MR, Punturieri A, Shero ST, Young NS, Zou S, Mensah GA. Perspectives from NHLBI Global Health Think Tank Meeting for Late Stage (T4) Translation Research. Global Heart 2017, 12: 341-348. PMID: 27452772, DOI: 10.1016/j.gheart.2016.03.640.Peer-Reviewed Original ResearchConceptsNational HeartDisease burdenNoncommunicable disease burdenHealth delivery modelsGlobal health researchMiddle-income countriesBlood InstituteGlobal health disparitiesThink Tank meetingHealth disparitiesEffective interventionsCompelling scientific questionsLungTank meetingHealth researchSustainable interventionsHeartThree-quartersDelivery modelInterventionBurdenImplementation strategiesResearch capacityMajor themesLater stagesAre non-ST-segment elevation myocardial infarctions missing in China?
Murugiah K, Wang Y, Nuti SV, Li X, Li J, Zheng X, Downing NS, Desai NR, Masoudi FA, Spertus JA, Jiang L, Krumholz HM, Group F. Are non-ST-segment elevation myocardial infarctions missing in China? European Heart Journal - Quality Of Care And Clinical Outcomes 2017, 3: 319-327. PMID: 28950309, DOI: 10.1093/ehjqcco/qcx025.Peer-Reviewed Original ResearchLiving Longer in Good Cardiovascular Health
Nasir K, Keeley B, Krumholz HM. Living Longer in Good Cardiovascular Health. Circulation 2017, 135: 1702-1704. PMID: 28461415, DOI: 10.1161/circulationaha.117.027960.Peer-Reviewed Original Research
2015
Biomarkers, Risk Factors, and Risk
Krumholz HM. Biomarkers, Risk Factors, and Risk. Circulation Cardiovascular Quality And Outcomes 2015, 8: 457-459. PMID: 26349839, PMCID: PMC5322983, DOI: 10.1161/circoutcomes.115.002245.Peer-Reviewed Original ResearchNational assessment of early β-blocker therapy in patients with acute myocardial infarction in China, 2001-2011: The China Patient-centered Evaluative Assessment of Cardiac Events (PEACE)–Retrospective AMI Study
Zhang H, Masoudi FA, Li J, Wang Q, Li X, Spertus JA, Ross JS, Desai NR, Krumholz HM, Jiang L, Group C. National assessment of early β-blocker therapy in patients with acute myocardial infarction in China, 2001-2011: The China Patient-centered Evaluative Assessment of Cardiac Events (PEACE)–Retrospective AMI Study. American Heart Journal 2015, 170: 506-515.e1. PMID: 26385034, PMCID: PMC5459420, DOI: 10.1016/j.ahj.2015.05.012.Peer-Reviewed Original ResearchConceptsΒ-blocker therapyAcute myocardial infarctionΒ-blocker useCardiogenic shockRisk factorsAbsolute contraindicationMyocardial infarctionEarly β-blocker useLower systolic blood pressureHours of admissionMedical record reviewSystolic blood pressureClinical practice guidelinesLower heart rateQuality of careChest discomfortCardiac eventsBlood pressureRecord reviewChina PatientIdeal patientPractice guidelinesHeart rateHigh riskPatterns of use
2014
Trends in Acute Myocardial Infarction in Young Patients and Differences by Sex and Race, 2001 to 2010
Gupta A, Wang Y, Spertus JA, Geda M, Lorenze N, Nkonde-Price C, D'Onofrio G, Lichtman JH, Krumholz HM. Trends in Acute Myocardial Infarction in Young Patients and Differences by Sex and Race, 2001 to 2010. Journal Of The American College Of Cardiology 2014, 64: 337-345. PMID: 25060366, PMCID: PMC4415523, DOI: 10.1016/j.jacc.2014.04.054.Peer-Reviewed Original ResearchConceptsAcute myocardial infarctionLength of stayHospital mortalityHospitalization ratesClinical characteristicsAge groupsAMI hospitalization ratesYounger patientsMyocardial infarctionLonger LOSNationwide Inpatient Sample dataYoung womenU.S. hospital dischargesPrevalence of comorbiditiesPrincipal discharge diagnosisNational Inpatient SampleSex differencesContemporary longitudinal dataLarge national datasetMore comorbiditiesHospital dischargeDischarge diagnosisInpatient SampleMortality rateAge 30
2013
Hospital-Based, Acute Care Use Among Patients Within 30 Days of Discharge After Coronary Artery Bypass Surgery
Fox JP, Suter LG, Wang K, Wang Y, Krumholz HM, Ross JS. Hospital-Based, Acute Care Use Among Patients Within 30 Days of Discharge After Coronary Artery Bypass Surgery. The Annals Of Thoracic Surgery 2013, 96: 96-104. PMID: 23702228, PMCID: PMC3758868, DOI: 10.1016/j.athoracsur.2013.03.091.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultAgedAged, 80 and overCaliforniaCoronary Artery BypassCoronary Artery DiseaseEmergency Service, HospitalFemaleFollow-Up StudiesHumansIntensive Care UnitsLength of StayLinear ModelsMaleMiddle AgedMorbidityPatient DischargePatient ReadmissionPostoperative ComplicationsPostoperative PeriodPrognosisRecurrenceRetrospective StudiesRisk FactorsSurvival RateTime FactorsYoung AdultConceptsDays of dischargeAcute care needsCABG surgeryED visit ratesED visitsHospital readmissionReadmission ratesCare needsCoronary artery bypass graft surgeryVisit ratesArtery bypass graft surgeryCoronary artery bypass surgeryRisk-standardized readmission ratesAcute care ratesHospital 30 daysBypass graft surgeryAcute care useArtery bypass surgeryCongestive heart failureEmergency department visitsEmergency Department DatabasesChest discomfortGraft surgeryBypass surgeryHospital volume
2005
Pharmacologic prophylaxis for postoperative atrial tachyarrhythmia in general thoracic surgery: Evidence from randomized clinical trials
Sedrakyan A, Treasure T, Browne J, Krumholz H, Sharpin C, van der Meulen J. Pharmacologic prophylaxis for postoperative atrial tachyarrhythmia in general thoracic surgery: Evidence from randomized clinical trials. Journal Of Thoracic And Cardiovascular Surgery 2005, 129: 997-1005. PMID: 15867772, DOI: 10.1016/j.jtcvs.2004.07.042.Peer-Reviewed Original ResearchMeSH KeywordsAdrenergic beta-AntagonistsAgedAmiodaroneAnti-Arrhythmia AgentsAtrial FibrillationAtrial FlutterCalcium Channel BlockersDigitalis GlycosidesEvidence-Based MedicineFemaleFlecainideHospital CostsHumansLength of StayMagnesiumMaleMiddle AgedMorbidityPostoperative ComplicationsPremedicationPreoperative CareRandomized Controlled Trials as TopicTachycardia, SupraventricularThoracic Surgical ProceduresTreatment OutcomeConceptsPostoperative atrial tachyarrhythmiasGeneral thoracic surgeryAtrial tachyarrhythmiasCalcium channel blockersRandomized clinical trialsThoracic surgeryClinical trialsSingle small trialLonger hospital stayUse of digitalisPossible adverse eventsFixed-effects modelAntiarrhythmic medicationsPharmacologic prophylaxisHospital stayProphylactic regimenAdverse eventsCommon complicationPulmonary edemaSignificant morbidityUnblinded trialCochrane DatabaseProphylactic useSmall trialsPlacebo control
2002
The Burden of Chronic Congestive Heart Failure in Older Persons: Magnitude and Implications for Policy and Research
Masoudi FA, Havranek EP, Krumholz HM. The Burden of Chronic Congestive Heart Failure in Older Persons: Magnitude and Implications for Policy and Research. Heart Failure Reviews 2002, 7: 9-16. PMID: 11790919, DOI: 10.1023/a:1013793621248.Peer-Reviewed Original ResearchConceptsHeart failureOlder populationChronic congestive heart failureOlder personsPoor long-term survivalMore hospital admissionsCongestive heart failureLong-term survivalHospital admissionHigh riskFailureSingle conditionPopulationPersonsHospitalizationAdmissionDearth of researchYearsDiagnosisMonths
1994
Lack of Association Between Cholesterol and Coronary Heart Disease Mortality and Morbidity and All-Cause Mortality in Persons Older Than 70 Years
Krumholz HM, Seeman TE, Merrill SS, Mendes de Leon CF, Vaccarino V, Silverman DI, Tsukahara R, Ostfeld AM, Berkman LF. Lack of Association Between Cholesterol and Coronary Heart Disease Mortality and Morbidity and All-Cause Mortality in Persons Older Than 70 Years. JAMA 1994, 272: 1335-1340. PMID: 7772105, DOI: 10.1001/jama.1994.03520170045034.Peer-Reviewed Original ResearchConceptsCoronary heart disease mortalityHeart disease mortalityTotal serum cholesterolSerum cholesterol levelsRisk factor-adjusted odds ratioFactor-adjusted odds ratiosTotal serum cholesterol levelsCause mortalityCoronary heart diseaseHDL-C levelsUnstable anginaHighest tertileCholesterol levelsSerum cholesterolMyocardial infarctionDisease mortalityLow HDLLowest tertileHeart diseaseRisk factorsOdds ratioElevated total serum cholesterol levelsHigher total serum cholesterolCommunity-based cohort studyHigh-density lipoprotein cholesterol