2022
Clinical decision support in cardiovascular medicine
Lu Y, Melnick ER, Krumholz HM. Clinical decision support in cardiovascular medicine. The BMJ 2022, 377: e059818. PMID: 35613721, DOI: 10.1136/bmj-2020-059818.Peer-Reviewed Original ResearchConceptsCardiovascular diseaseCardiovascular careEffectiveness of CDSRisk factor modificationClinical decision support toolQuality of careClinical decision supportClinical outcomesFactor modificationHealth information technologyClinical practicePatient careDiseaseCardiovascular medicineCDS effectivenessCareEffectiveness of deliveryMissed opportunityTreatmentFailureProper evidenceHealthcare processesMedicineEvidencePrevention
2020
Evaluation of a Risk Stratification Model Using Preoperative and Intraoperative Data for Major Morbidity or Mortality After Cardiac Surgical Treatment
Durant TJS, Jean RA, Huang C, Coppi A, Schulz WL, Geirsson A, Krumholz HM. Evaluation of a Risk Stratification Model Using Preoperative and Intraoperative Data for Major Morbidity or Mortality After Cardiac Surgical Treatment. JAMA Network Open 2020, 3: e2028361. PMID: 33284333, DOI: 10.1001/jamanetworkopen.2020.28361.Peer-Reviewed Original Research
2019
Prevalence, Awareness, and Treatment of Isolated Diastolic Hypertension: Insights From the China PEACE Million Persons Project
Mahajan S, Zhang D, He S, Lu Y, Gupta A, Spatz ES, Lu J, Huang C, Herrin J, Liu S, Yang J, Wu C, Cui J, Zhang Q, Li X, Nasir K, Zheng X, Krumholz HM, Li J, Dong Z, Jiang B, Zhang Y, Liu Y, Meng Y, Xi Y, Tian Y, Fu Y, Liu T, Yan S, Jin L, Wang J, Xu X, Xing X, Zhang L, Fang X, Xu Y, Xu C, Fan L, Qi M, Qi J, Li J, Liu Q, Feng Y, Wang J, Wen H, Xu J, He J, Jiang C, Yang C, Yu Y, Tashi Z, Hu Z, Zhang J, Li X, Ma S, Ma Y, Huang Y, Zhang Y, Shen J. Prevalence, Awareness, and Treatment of Isolated Diastolic Hypertension: Insights From the China PEACE Million Persons Project. Journal Of The American Heart Association 2019, 8: e012954. PMID: 31566101, PMCID: PMC6806046, DOI: 10.1161/jaha.119.012954.Peer-Reviewed Original ResearchConceptsMillion Persons ProjectPrior cardiovascular eventsBody mass indexAntihypertensive medicationsDiastolic hypertensionCardiovascular eventsDiabetes mellitusMass indexIsolated diastolic hypertensionDiastolic blood pressureSelf-reported diagnosisTreatment of peoplePersons ProjectBlood pressureTreatment patternsHypertensionLeast collegeHigher likelihoodMellitusMedicationsPrevalenceTreatmentDiagnosisSubstantial numberCurrent use
2010
Who is missing from the measures? Trends in the proportion and treatment of patients potentially excluded from publicly reported quality measures
Bernheim SM, Wang Y, Bradley EH, Masoudi FA, Rathore SS, Ross JS, Drye E, Krumholz HM. Who is missing from the measures? Trends in the proportion and treatment of patients potentially excluded from publicly reported quality measures. American Heart Journal 2010, 160: 943-950.e5. PMID: 21095284, PMCID: PMC3319386, DOI: 10.1016/j.ahj.2010.06.046.Peer-Reviewed Original ResearchMeSH KeywordsAdrenergic beta-AntagonistsAgedAngiotensin-Converting Enzyme InhibitorsCross-Sectional StudiesFemaleHospitalizationHumansMaleMedicaidMedicareMyocardial InfarctionOutcome and Process Assessment, Health CarePlatelet Aggregation InhibitorsPrognosisQuality ImprovementQuality Indicators, Health CareRetrospective StudiesUnited StatesConceptsAcute myocardial infarctionProportion of patientsRelative contraindicationAngiotensin-converting enzyme inhibitorTreatment of patientsMedicaid Services core measuresQuality improvement projectPublic reportingCross-sectional analysisMyocardial infarctionMedicare patientsHospital careΒ-blockersAMI admissionsPatientsInsufficient evidenceEnzyme inhibitorsTreatment ratesBetter careContraindicationsMedicaid ServicesData cohortCore measuresTreatmentImprovement projectApplying Practice Recommendations for the Prevention and Treatment of Obesity in Children and Adolescents
Dorsey KB, Mauldon M, Magraw R, Valka J, Yu S, Krumholz HM. Applying Practice Recommendations for the Prevention and Treatment of Obesity in Children and Adolescents. Clinical Pediatrics 2010, 49: 137-145. PMID: 20080520, DOI: 10.1177/0009922809346567.Peer-Reviewed Original ResearchConceptsCross-sectional analysisObese patientsFifth visitDocumentation of BMIFirst clinic visitTreatment of obesityLongitudinal analysisIndividual risk behaviorsClinic visitsClinician adherenceMedical recordsWeight managementObesity preventionFirst visitClinicians' attentionRisk behaviorsPatientsPractice recommendationsVisitsOverweightBMIPreventionAdherenceTreatmentObesity
2009
Association of Door-to-Balloon Time and Mortality in Patients ≥65 Years With ST-Elevation Myocardial Infarction Undergoing Primary Percutaneous Coronary Intervention
Rathore SS, Curtis JP, Nallamothu BK, Wang Y, Foody JM, Kosiborod M, Masoudi FA, Havranek EP, Krumholz HM. Association of Door-to-Balloon Time and Mortality in Patients ≥65 Years With ST-Elevation Myocardial Infarction Undergoing Primary Percutaneous Coronary Intervention. The American Journal Of Cardiology 2009, 104: 1198-1203. PMID: 19840562, PMCID: PMC2790921, DOI: 10.1016/j.amjcard.2009.06.034.Peer-Reviewed Original ResearchConceptsPrimary percutaneous coronary interventionPrimary PCIST-elevation myocardial infarctionPercutaneous coronary interventionBalloon timeMyocardial infarctionCoronary interventionAssociation of doorMinutes of admissionSecond-degree fractional polynomialsLogistic regression analysisFractional polynomial modelsMultivariable adjustmentLonger doorMedian doorCurrent guidelinesPatientsMortalityInfarctionRegression analysisFractional polynomialsAssociationInterventionMinutesTreatment
2007
“America's Best Hospitals” in the Treatment of Acute Myocardial Infarction
Wang OJ, Wang Y, Lichtman JH, Bradley EH, Normand SL, Krumholz HM. “America's Best Hospitals” in the Treatment of Acute Myocardial Infarction. JAMA Internal Medicine 2007, 167: 1345-1351. PMID: 17620526, DOI: 10.1001/archinte.167.13.1345.Peer-Reviewed Original ResearchConceptsAcute myocardial infarctionStandardized mortality ratioBest HospitalsMyocardial infarctionAmerica's Best HospitalsTreatment of AMIMedicare administrative dataHeart surgeryMortality ratioLower riskMortality rateHospitalQuartile distributionPatientsRSMRInfarctionAdministrative dataOne-thirdHierarchical regression modelsRSMRsRegression modelsTreatmentSurgeryAdmissionQuartile
2005
Diagnosis, Evaluation, and Treatment of Childhood Obesity in Pediatric Practice
Dorsey KB, Wells C, Krumholz HM, Concato J. Diagnosis, Evaluation, and Treatment of Childhood Obesity in Pediatric Practice. JAMA Pediatrics 2005, 159: 632-638. PMID: 15996996, DOI: 10.1001/archpedi.159.7.632.Peer-Reviewed Original ResearchConceptsBody mass indexRisk of overweightHospital-based clinicsHealth maintenance visitsRate of diagnosisType of treatmentComorbid diseasesMass indexOverweight childrenChildhood obesityMedical recordsTreatment recommendationsHigh burdenPediatric practiceRoutine screeningOverweightClinical practiceMaintenance visitsDiagnosisEncounter notesFormal diagnosisTreatmentChildrenSingle-parent householdsRiskRacial differences in reperfusion therapy use in patients hospitalized with myocardial infarction: A regional phenomenon
Rathore SS, Frederick PD, Every NR, Barron HV, Krumholz HM. Racial differences in reperfusion therapy use in patients hospitalized with myocardial infarction: A regional phenomenon. American Heart Journal 2005, 149: 1074-1081. PMID: 15976791, PMCID: PMC2790272, DOI: 10.1016/j.ahj.2004.08.018.Peer-Reviewed Original ResearchConceptsTherapy useMyocardial infarctionBlack patientsReperfusion therapyWhite patientsRacial differencesLower crude ratesMyocardial Infarction 2Reperfusion therapy ratesCohort of patientsTherapy ratesMultivariable adjustmentClinical contraindicationsNational registryPractice patternsCrude ratePatientsInfarctionGeographic regionsTherapyLower ratesTreatmentNational patternsContraindicationsDifferences
2004
Differences, disparities, and biases: clarifying racial variations in health care use.
Rathore SS, Krumholz HM. Differences, disparities, and biases: clarifying racial variations in health care use. Annals Of Internal Medicine 2004, 141: 635-8. PMID: 15492343, DOI: 10.7326/0003-4819-141-8-200410190-00011.Peer-Reviewed Original ResearchConceptsHealth care useCare useRacial variationRacial differencesHealth care system factorsAdverse consequencesClinical factorsClinical contraindicationsTreatment eligibilityPatient preferencesObservational studyEvidence of differencesMedical literatureRacial disparitiesHealth careInitial reportSystem factorsDifferent causesTreatmentReports of variationReportDisparitiesContraindicationsDifferencesCare
2002
The Cost-Effectiveness of Treatment for Varicocele Related Infertility
PENSON D, PALTIEL A, KRUMHOLZ H, PALTER S. The Cost-Effectiveness of Treatment for Varicocele Related Infertility. Journal Of Urology 2002, 168: 2490-2494. DOI: 10.1097/00005392-200212000-00033.Peer-Reviewed Original ResearchImmediate IVFHealth care payorsRelated infertilityIntrauterine inseminationTreatment strategiesLive deliveryMain outcome measuresNumber of newbornsAdditional birthsCost-effectiveness analysisInfertile patientsImproved outcomesOutcome measuresPatient's perspectiveSurgical varicocelectomyAbstract PurposeIVFIncremental costInfertilityPatientsTreatmentPreferred approachBirthPayorsDeliveryThe Cost-Effectiveness of Treatment for Varicocele Related Infertility
PENSON DF, PALTIEL AD, KRUMHOLZ HM, PALTER S. The Cost-Effectiveness of Treatment for Varicocele Related Infertility. Journal Of Urology 2002, 168: 2490-2494. PMID: 12441947, DOI: 10.1016/s0022-5347(05)64175-4.Peer-Reviewed Original ResearchConceptsImmediate IVFHealth care payorsRelated infertilityIntrauterine inseminationTreatment strategiesLive deliveryMain outcome measuresNumber of newbornsAdditional birthsCost-effectiveness analysisInfertile patientsImproved outcomesOutcome measuresPatient's perspectiveSurgical varicocelectomyIVFIncremental costInfertilityPatientsTreatmentPreferred approachBirthPayorsDeliveryVaricocelectomy
1999
Cost-Effectiveness Analysis and the Treatment of Acute Coronary Syndromes
Krumholz H. Cost-Effectiveness Analysis and the Treatment of Acute Coronary Syndromes. Contemporary Cardiology 1999, 601-610. DOI: 10.1007/978-1-59259-731-4_25.Peer-Reviewed Original ResearchAcute coronary syndromeCoronary heart diseaseHealth care resourcesCost-effectiveness analysisHealth care systemHealth care expendituresCoronary syndromeCardiac eventsPharmacologic interventionsHeart diseaseEfficacious therapyCardiovascular diseaseCare resourcesNew interventionsCare expendituresCare systemHealth benefitsInterventionCare organizationsDiseaseTreatmentStandard practicePatientsHospitalSyndrome
1998
Use and Effectiveness of Intravenous Heparin Therapy for Treatment of Acute Myocardial Infarction in the Elderly
Krumholz H, Hennen J, Ridker P, Murillo J, Wang Y, Vaccarino V, Ellerbeck E, Radford M. Use and Effectiveness of Intravenous Heparin Therapy for Treatment of Acute Myocardial Infarction in the Elderly. Journal Of The American College Of Cardiology 1998, 31: 973-979. PMID: 9561996, DOI: 10.1016/s0735-1097(98)00022-9.Peer-Reviewed Original ResearchConceptsAcute myocardial infarctionIntravenous heparin therapyIntravenous heparinMyocardial infarctionHeparin therapyMortality rateFull-dose intravenous heparinRetrospective cohort studyHospital medical recordsUse of heparinReperfusion strategyCohort studyElderly patientsMedical recordsBaseline differencesObservational studyMedicare beneficiariesInfarctionTherapeutic effectivenessPatientsTreatment factorsHeparinContraindicationsTreatmentTherapy