2021
Predictors of increased mortality in untreated moderate aortic stenosis
Gupta A, Liu T, Pounds C, Sharma R, Yong C, Krumholz H, Leon M. Predictors of increased mortality in untreated moderate aortic stenosis. European Heart Journal 2021, 42: ehab724.1573. DOI: 10.1093/eurheartj/ehab724.1573.Peer-Reviewed Original ResearchModerate aortic stenosisLong-term mortalityCoronary artery diseaseSeverity of ASAortic stenosisArtery diseaseAtrial fibrillationHeart failureUntreated severe aortic stenosisWorse long-term mortalityPoor long-term survivalSevere aortic stenosisAortic valve replacementHigh-risk featuresMild aortic stenosisPrognosis of patientsKaplan-Meier analysisLong-term survivalElectronic health recordsValve replacementAS severityMale sexRisk factorsSeverity groupsHigh riskClinical characteristics and outcomes for 7,995 patients with SARS-CoV-2 infection
McPadden J, Warner F, Young HP, Hurley NC, Pulk RA, Singh A, Durant TJS, Gong G, Desai N, Haimovich A, Taylor RA, Gunel M, Dela Cruz CS, Farhadian SF, Siner J, Villanueva M, Churchwell K, Hsiao A, Torre CJ, Velazquez EJ, Herbst RS, Iwasaki A, Ko AI, Mortazavi BJ, Krumholz HM, Schulz WL. Clinical characteristics and outcomes for 7,995 patients with SARS-CoV-2 infection. PLOS ONE 2021, 16: e0243291. PMID: 33788846, PMCID: PMC8011821, DOI: 10.1371/journal.pone.0243291.Peer-Reviewed Original ResearchConceptsSARS-CoV-2 infectionYale New Haven HealthSARS-CoV-2Hospital mortalityRisk of admissionMale sexRisk factorsSARS-CoV-2 testingInvasive mechanical ventilationSevere acute respiratory syndrome virusBurden of diseaseRT-PCR testingAcademic health systemDiverse patient populationsRespiratory syndrome virusEthnic groupsAdult patientsClinical characteristicsDischarge dispositionRespiratory supportPrimary outcomeTreatment guidelinesMechanical ventilationRetrospective studyPatient population
2019
Variation and Disparities in Awareness of Myocardial Infarction Symptoms Among Adults in the United States
Mahajan S, Valero-Elizondo J, Khera R, Desai NR, Blankstein R, Blaha MJ, Virani SS, Kash BA, Zoghbi WA, Krumholz HM, Nasir K. Variation and Disparities in Awareness of Myocardial Infarction Symptoms Among Adults in the United States. JAMA Network Open 2019, 2: e1917885. PMID: 31851350, PMCID: PMC6991230, DOI: 10.1001/jamanetworkopen.2019.17885.Peer-Reviewed Original ResearchConceptsMyocardial infarction symptomsShortness of breathMyocardial infarctionInfarction symptomsLow education levelEmergency medical servicesChest painSociodemographic subgroupsNational Health Interview SurveyEmergency cardiac careCross-sectional studyMedical servicesHealth Interview SurveyPublic health initiativesEducation levelLow-income subgroupsPrompt recognitionBack painCommon symptomsMale sexCardiac careHigher oddsHispanic ethnicityMAIN OUTCOMEHigh risk
2009
Determinants of Cardiac Catheterization Use in Older Medicare Patients With Acute Myocardial Infarction
Ko DT, Ross JS, Wang Y, Krumholz HM. Determinants of Cardiac Catheterization Use in Older Medicare Patients With Acute Myocardial Infarction. Circulation Cardiovascular Quality And Outcomes 2009, 3: 54-62. PMID: 20123672, PMCID: PMC3024143, DOI: 10.1161/circoutcomes.109.858456.Peer-Reviewed Original ResearchMeSH KeywordsAge FactorsAgedAged, 80 and overCardiac CatheterizationChi-Square DistributionComorbidityFemaleHemorrhageHospitalizationHumansLikelihood FunctionsLogistic ModelsMaleMedicareMyocardial InfarctionPatient SelectionPractice Patterns, Physicians'Risk AssessmentRisk FactorsSeverity of Illness IndexSex FactorsTime FactorsTreatment OutcomeUnited StatesConceptsAcute myocardial infarctionCardiac catheterization useCardiac catheterizationInappropriate indicationsAMI patientsAppropriate indicationsMyocardial infarctionRisk scoreCardiology/American Heart Association class IBaseline cardiovascular riskOlder Medicare patientsHigh-risk patientsDemographic factorsMore comorbiditiesCardiovascular riskOlder patientsMale sexProcedure indicationFemale sexMedicare patientsAmerican CollegeAMI admissionsMedicare feePatientsCatheterization
1999
Risk factors for heart failure in the elderly: a prospective community-based study
Chen Y, Vaccarino V, Williams C, Butler J, Berkman L, Krumholz H. Risk factors for heart failure in the elderly: a prospective community-based study. The American Journal Of Medicine 1999, 106: 605-612. PMID: 10378616, DOI: 10.1016/s0002-9343(99)00126-6.Peer-Reviewed Original ResearchConceptsTraditional cardiovascular risk factorsCardiovascular risk factorsHeart failureRisk factorsMyocardial infarctionRisk ratioCommunity-based elderly populationProportional hazards regression modelsProspective community-based studyIncident heart failureBody mass indexHazards regression modelsConfidence intervalsCommunity-based studyManagement of diabetesYears of ageConnecticut cohortChart reviewBlood pressureIndependent predictorsMass indexMale sexElderly ProgramPulse pressurePreventive strategies
1997
Readmission After Hospitalization for Congestive Heart Failure Among Medicare Beneficiaries
Krumholz HM, Parent EM, Tu N, Vaccarino V, Wang Y, Radford MJ, Hennen J. Readmission After Hospitalization for Congestive Heart Failure Among Medicare Beneficiaries. JAMA Internal Medicine 1997, 157: 99-104. PMID: 8996046, DOI: 10.1001/archinte.1997.00440220103013.Peer-Reviewed Original ResearchConceptsCongestive heart failureHeart failureMedicare beneficiariesIndex admissionElderly patientsReadmission ratesCommon discharge diagnosesDeyo comorbidity scoreOutcomes of readmissionSingle-center studySpectrum of diagnosesLength of stayDeterminants of readmissionSignificant predictorsMedicare administrative filesComorbidity scoreIndex hospitalizationStudy patientsFiscal year 1991Prior admissionCommon diagnosisMultivariable analysisDischarge diagnosisMale sexAdverse outcomes