A mosquito AgTRIO mRNA vaccine contributes to immunity against malaria
Chuang Y, Alameh M, Abouneameh S, Raduwan H, Ledizet M, Weissman D, Fikrig E. A mosquito AgTRIO mRNA vaccine contributes to immunity against malaria. Npj Vaccines 2023, 8: 88. PMID: 37286568, PMCID: PMC10244833, DOI: 10.1038/s41541-023-00679-x.Peer-Reviewed Original ResearchHumoral responseFuture malaria vaccinesMosquito saliva proteinsRobust humoral responseImmunization of miceVector antigensIsotype antibodiesIgG titersImmunized miceMalaria vaccinePassive immunizationIgG2a isotypesMRNA vaccinesPlasmodium infectionMosquito bitesMRNA lipid nanoparticlesVaccineMRNA-LNPPlasmodium sporozoitesMalariaMiceImmunizationSaliva proteinsPotential usefulnessVertebrate hostsMosquito Salivary Proteins and Arbovirus Infection: From Viral Enhancers to Potential Targets for Vaccines
Marín-López A, Raduwan H, Chen T, Utrilla-Trigo S, Wolfhard D, Fikrig E. Mosquito Salivary Proteins and Arbovirus Infection: From Viral Enhancers to Potential Targets for Vaccines. Pathogens 2023, 12: 371. PMID: 36986293, PMCID: PMC10054260, DOI: 10.3390/pathogens12030371.Peer-Reviewed Original ResearchMosquito salivary proteinsImmune responseImportant public health challengeAdaptive immune responsesHost immune responsePublic health challengeNon-endemic areasSalivary proteinsSerious complicationsLicensed vaccineNeurological alterationsMosquito salivaClinical signsMosquito bitesHemorrhagic feverInfection outcomesRapid onsetArbovirus infectionExplosive outbreaksHealth challengesVaccineDifferent arbovirusesArboviral diseasesArthropod salivaPotential target