2024
Contemporary Prestroke Dual Antiplatelet Use and Symptomatic Intracerebral Hemorrhage Risk After Thrombolysis
Peng T, Schwamm L, Fonarow G, Hassan A, Hill M, Messé S, Coronado F, Falcone G, Sharma R. Contemporary Prestroke Dual Antiplatelet Use and Symptomatic Intracerebral Hemorrhage Risk After Thrombolysis. JAMA Neurology 2024, 81: 722-731. PMID: 38767894, PMCID: PMC11106713, DOI: 10.1001/jamaneurol.2024.1312.Peer-Reviewed Original ResearchRisk of symptomatic intracerebral hemorrhageSymptomatic intracerebral hemorrhageTreated with IV-tPAAcute ischemic strokeIV-tPAAmerican Heart Association and American Stroke AssociationAssociated with lower oddsIschemic strokeDual antiplatelet therapyAssociated with increased riskPropensity score subclassificationAmerican Stroke AssociationIntracerebral hemorrhage riskGWTG-StrokeSymptomatic intracerebral hemorrhage riskGuidelines-StrokeDischarge modified Rankin Scale scoreIn-hospital deathStroke AssociationLower oddsRate of symptomatic intracerebral hemorrhageAntiplatelet therapyCohort studyAssociated with symptomatic intracerebral hemorrhagePrestrokeBurden of Ischemic and Hemorrhagic Stroke Across the US From 1990 to 2019
Renedo D, Acosta J, Leasure A, Sharma R, Krumholz H, de Havenon A, Alahdab F, Aravkin A, Aryan Z, Bärnighausen T, Basu S, Burkart K, Coberly K, Criqui M, Dai X, Desai R, Dharmaratne S, Doshi R, Elgendy I, Feigin V, Filip I, Gad M, Ghozy S, Hafezi-Nejad N, Kalani R, Karaye I, Kisa A, Krishnamoorthy V, Lo W, Mestrovic T, Miller T, Misganaw A, Mokdad A, Murray C, Natto Z, Radfar A, Ram P, Roth G, Seylani A, Shah N, Sharma P, Sheikh A, Singh J, Song S, Sotoudeh H, Vervoort D, Wang C, Xiao H, Xu S, Zand R, Falcone G, Sheth K. Burden of Ischemic and Hemorrhagic Stroke Across the US From 1990 to 2019. JAMA Neurology 2024, 81: 394-404. PMID: 38436973, PMCID: PMC10913004, DOI: 10.1001/jamaneurol.2024.0190.Peer-Reviewed Original ResearchBurden of strokeHemorrhagic strokeBurden trendsGlobal burdenGlobal Burden of Disease StudyBurden of Disease StudyAge-standardized ratesAge-standardized estimatesPublic health policiesStroke-related outcomesIschemic strokeCross-sectional studyPublic health challengeCross-sectional analysisStroke mortalityStroke burdenHealth policyOlder adultsMain OutcomesStroke incidenceStroke casesIntracerebral hemorrhageEscalating burdenHealth challengesSignificant disparitiesEndovascular Treatment of Acute Ischemic Stroke After Cardiac Interventions in the United States
de Havenon A, Zhou L, Koo A, Matouk C, Falcone G, Sharma R, Ney J, Shu L, Yaghi S, Kamel H, Sheth K. Endovascular Treatment of Acute Ischemic Stroke After Cardiac Interventions in the United States. JAMA Neurology 2024, 81: 264-272. PMID: 38285452, PMCID: PMC10825786, DOI: 10.1001/jamaneurol.2023.5416.Peer-Reviewed Original ResearchNational Institutes of Health Stroke ScaleNational Institutes of Health Stroke Scale scoreOdds of discharge homeDischarged homeIschemic strokeRate of endovascular thrombectomyMultivariate logistic regressionNational Inpatient Sample databaseHealth Stroke ScaleIntervention patientsInpatient Sample databaseMain OutcomesIntervention statusHospitalization of patientsPotential confoundersUS hospitalsEndovascular thrombectomyStroke patientsCohort studySecondary outcomesLogistic regressionCardiac interventionsStroke severityStroke ScaleGroup of hospitalized patientsAssociation Between Hematoma Volume and Risk of Subsequent Ischemic Stroke: A MISTIE III and ATACH-2 Analysis
Harris W, Kaiser J, Liao V, Avadhani R, Iadecola C, Falcone G, Sheth K, Qureshi A, Goldstein J, Awad I, Hanley D, Kamel H, Ziai W, Murthy S. Association Between Hematoma Volume and Risk of Subsequent Ischemic Stroke: A MISTIE III and ATACH-2 Analysis. Stroke 2024, 55: 541-547. PMID: 38299346, PMCID: PMC10932908, DOI: 10.1161/strokeaha.123.045859.Peer-Reviewed Original ResearchConceptsIntracerebral hemorrhage volumeMedian ICH volumeRisk of ischemic strokeHematoma volumeIntracerebral hemorrhageIncreased risk of ischemic strokeATACH-2ICH volumeIschemic strokeCumulative incidenceMISTIE IIIIncreased riskLong-term increased riskIntracerebral hemorrhage characteristicsMedian hematoma volumeHeterogeneous cohort of patientsMedian follow-upPrimary analysisIntracerebral hemorrhage locationCohort of patientsNontraumatic intracerebral hemorrhageCox regression analysisShort-term risk of ischemic strokeCox regression modelsIndividual patient data
2023
Neighborhood Deprivation and Race Synergistically Contribute to Undiagnosed Hypertension Leading to Acute Ischemic Stroke: Results from the All of Us Research Program (P6-9.001)
Torres-Lopez V, Renedo D, Acosta J, Gill T, Sheth K, Falcone G, Rivier C. Neighborhood Deprivation and Race Synergistically Contribute to Undiagnosed Hypertension Leading to Acute Ischemic Stroke: Results from the All of Us Research Program (P6-9.001). Neurology 2023, 100 DOI: 10.1212/wnl.0000000000202154.Peer-Reviewed Original ResearchNeighborhood Deprivation and Polygenic Contribution to Acute Ischemic Stroke: Results from the All of Us Research Program (S49.007)
Rivier C, Acosta J, Renedo D, Gill T, Sheth K, Falcone G. Neighborhood Deprivation and Polygenic Contribution to Acute Ischemic Stroke: Results from the All of Us Research Program (S49.007). Neurology 2023, 100 DOI: 10.1212/wnl.0000000000202793.Peer-Reviewed Original Research
2022
Portable, low-field magnetic resonance imaging enables highly accessible and dynamic bedside evaluation of ischemic stroke
Yuen MM, Prabhat AM, Mazurek MH, Chavva IR, Crawford A, Cahn BA, Beekman R, Kim JA, Gobeske KT, Petersen NH, Falcone GJ, Gilmore EJ, Hwang DY, Jasne AS, Amin H, Sharma R, Matouk C, Ward A, Schindler J, Sansing L, de Havenon A, Aydin A, Wira C, Sze G, Rosen MS, Kimberly WT, Sheth KN. Portable, low-field magnetic resonance imaging enables highly accessible and dynamic bedside evaluation of ischemic stroke. Science Advances 2022, 8: eabm3952. PMID: 35442729, PMCID: PMC9020661, DOI: 10.1126/sciadv.abm3952.Peer-Reviewed Original ResearchIschemic strokeMagnetic resonance imagingResonance imagingFluid-attenuated inversion recoveryDiffusion-weighted imaging sequencesStroke volume measurementsStroke pathwayStroke severityFunctional outcomeLow-field magnetic resonance imagingBedside evaluationClinical managementStroke volumeMRI studiesStrokePatientsBrain imagingCerebellar structuresHigh-field MRI studiesHyperintense regionsInversion recoveryInfarctsUseful imagingVolume measurements
2021
Prior Stroke and Age Predict Acute Ischemic Stroke Among Hospitalized COVID-19 Patients: A Derivation and Validation Study
Peng TJ, Jasne AS, Simonov M, Abdelhakim S, Kone G, Cheng YK, Rethana M, Tarasaria K, Herman AL, Baker AD, Yaghi S, Frontera JA, Sansing LH, Falcone GJ, Spudich S, Schindler J, Sheth KN, Sharma R. Prior Stroke and Age Predict Acute Ischemic Stroke Among Hospitalized COVID-19 Patients: A Derivation and Validation Study. Frontiers In Neurology 2021, 12: 741044. PMID: 34675873, PMCID: PMC8524436, DOI: 10.3389/fneur.2021.741044.Peer-Reviewed Original ResearchAcute ischemic strokeHospitalized COVID-19 patientsCOVID-19 patientsCOVID-19 cohortNeurologic symptomsPrior strokeIschemic strokeAIS patientsDerivation cohortControl cohortRisk of AISMultivariable logistic regression modelIschemic stroke riskCOVID-19 severityYale New Haven HealthLogistic regression modelsHospital presentationIndependent predictorsStroke riskMajor health systemsHigh riskPatientsYounger ageCohortStrokeMendelian Randomization in Stroke: A Powerful Approach to Causal Inference and Drug Target Validation
Acosta JN, Szejko N, Falcone GJ. Mendelian Randomization in Stroke: A Powerful Approach to Causal Inference and Drug Target Validation. Frontiers In Genetics 2021, 12: 683082. PMID: 34456968, PMCID: PMC8387928, DOI: 10.3389/fgene.2021.683082.Peer-Reviewed Original ResearchMendelian randomizationCardiovascular risk factorsRisk of strokeAvailable treatment optionsInflammation-related mechanismsIschemic strokeHemorrhagic strokeTreatment optionsRisk factorsLeading causeCurrent evidenceTherapeutic targetStrokeMR studiesNovel biological pathwaysDrug repurposingDrug developmentDrug target validationRandomizationTarget validationExposureBiological pathwaysCausal relationshipDiseaseRisk of Mortality After an Arterial Ischemic Event Among Intracerebral Hemorrhage Survivors
Parasram M, Parikh NS, Merkler AE, Falcone GJ, Sheth KN, Navi BB, Kamel H, Zhang C, Murthy SB. Risk of Mortality After an Arterial Ischemic Event Among Intracerebral Hemorrhage Survivors. The Neurohospitalist 2021, 12: 19-23. PMID: 34950382, PMCID: PMC8689534, DOI: 10.1177/19418744211026709.Peer-Reviewed Original ResearchArterial ischemic eventsRisk of deathIschemic eventsIntracerebral hemorrhageMyocardial infarctionIschemic strokeMarginal structural modelsICH patientsMedicare beneficiariesNon-traumatic intracerebral hemorrhageICD-9-CM diagnosis codesAcute ischemic strokeRetrospective cohort studySubsequent ischemic strokeIntracerebral hemorrhage survivorsRisk of mortalityICH survivorsMedian followElderly patientsCohort studyDiagnosis codesClaims dataMortality riskMortality rateTime-varying covariatesDiffusion-Weighted Imaging Lesions After Intracerebral Hemorrhage and Risk of Stroke
Murthy SB, Zhang C, Gupta A, Cho SM, Rivera-Lara L, Avadhani R, Gruber J, Iadecola C, Falcone GJ, Sheth KN, Qureshi AI, Goldstein JN, Hanley DF, Kamel H, Ziai WC. Diffusion-Weighted Imaging Lesions After Intracerebral Hemorrhage and Risk of Stroke. Stroke 2021, 52: 595-602. PMID: 33467877, PMCID: PMC8340082, DOI: 10.1161/strokeaha.120.031628.Peer-Reviewed Original ResearchConceptsRecurrent intracerebral hemorrhageRisk of strokeIntracerebral hemorrhageDWI lesionsIschemic strokeDiffusion-weighted imagingDiffusion-weighted imaging lesionsMultivariate Cox regression analysisMISTIE III trialIncident ischemic strokeCox regression analysisPoor functional outcomeCox regression modelIndividual patient dataATACH-2 trialLong-term riskMagnetic resonance imagingICH survivorsIncident strokeIII trialsImaging lesionsSecondary outcomesIschemic lesionsPrimary outcomeFunctional outcome
2020
Statin treatment and cerebral microbleeds: A systematic review and meta-analysis
Katsanos AH, Lioutas VA, Charidimou A, Catanese L, Ng KKH, Perera K, Boasquevisque D, Falcone GJ, Sheth KN, Romero JR, Tsivgoulis G, Smith EE, Sharma M, Selim MH, Shoamanesh A, Initiative T. Statin treatment and cerebral microbleeds: A systematic review and meta-analysis. Journal Of The Neurological Sciences 2020, 420: 117224. PMID: 33183779, DOI: 10.1016/j.jns.2020.117224.Peer-Reviewed Original ResearchConceptsCMB presenceStatin useCurrent statin useStatin treatmentRandomized-controlled clinical trialSpontaneous intracerebral hemorrhageRandom-effects modelCMB prevalenceIschemic strokeHemorrhagic strokeAdjusted analysisCerebral microbleedsIntracerebral hemorrhageRandomized trialsUnadjusted analysesClinical trialsEligible studiesAncillary studiesObservational studyPooled estimatesGeneral populationSystematic reviewUnadjusted probabilitySystematic searchCross-sectional dataCause of death in spontaneous intracerebral hemorrhage survivors: Multistate longitudinal study.
Kuohn LR, Leasure AC, Acosta JN, Vanent K, Murthy SB, Kamel H, Matouk CC, Sansing LH, Falcone GJ, Sheth KN. Cause of death in spontaneous intracerebral hemorrhage survivors: Multistate longitudinal study. Neurology 2020, 95: e2736-e2745. PMID: 32917797, PMCID: PMC7734723, DOI: 10.1212/wnl.0000000000010736.Peer-Reviewed Original ResearchConceptsCause of deathRecurrent intracranial hemorrhageIntracerebral hemorrhage survivorsAtrial fibrillationICH survivorsIschemic strokeIntracranial hemorrhageSpontaneous intracerebral hemorrhage survivorsMultivariable Cox proportional hazardsCox proportional hazardsLong-term survivalMedian followRespiratory failureHospital readmissionPrimary outcomePrimary diagnosisSpontaneous ICHCardiac diseaseClaims dataMultinomial logistic regressionNontraumatic ICHProportional hazardsAdult survivorsLogistic regressionPatientsNon-Traumatic Subdural Hemorrhage and Risk of Arterial Ischemic Events
Murthy SB, Wu X, Diaz I, Parasram M, Parikh NS, Iadecola C, Merkler AE, Falcone GJ, Brown S, Biffi A, Ch'ang J, Knopman J, Stieg PE, Navi BB, Sheth KN, Kamel H. Non-Traumatic Subdural Hemorrhage and Risk of Arterial Ischemic Events. Stroke 2020, 51: 1464-1469. PMID: 32178587, PMCID: PMC7188584, DOI: 10.1161/strokeaha.119.028510.Peer-Reviewed Original ResearchConceptsArterial ischemic eventsAcute ischemic strokeIschemic eventsIschemic strokeSubdural hemorrhageMyocardial infarctionAntithrombotic therapyMedicare beneficiariesSDH diagnosisPatient riskSecondary analysisRetrospective cohort studyAcute myocardial infarctionCohort studyHazard ratioSecondary outcomesVascular comorbiditiesPrimary outcomeCox regressionDiagnosis codesClaims dataInternational ClassificationPrimary analysisInfarctionStrokeFixed Compared With Autoregulation-Oriented Blood Pressure Thresholds After Mechanical Thrombectomy for Ischemic Stroke
Petersen NH, Silverman A, Strander SM, Kodali S, Wang A, Sansing LH, Schindler JL, Falcone GJ, Gilmore EJ, Jasne AS, Cord B, Hebert RM, Johnson M, Matouk CC, Sheth KN. Fixed Compared With Autoregulation-Oriented Blood Pressure Thresholds After Mechanical Thrombectomy for Ischemic Stroke. Stroke 2020, 51: 914-921. PMID: 32078493, PMCID: PMC7050651, DOI: 10.1161/strokeaha.119.026596.Peer-Reviewed Original ResearchConceptsSystolic BP thresholdMean arterial pressureArterial pressureEndovascular thrombectomyIschemic strokeSystolic BPFunctional outcomePercent timeFurther brain injuryModified Rankin ScaleBlood pressure changesPoor functional outcomeBP thresholdAutoregulatory indexHemorrhagic transformationMechanical thrombectomyRankin ScaleBlood pressureBP targetsHemodynamic managementAcute phaseBP managementStroke patientsCerebral autoregulationWorse outcomes
2019
Decreases in Blood Pressure During Thrombectomy Are Associated With Larger Infarct Volumes and Worse Functional Outcome
Petersen NH, Ortega-Gutierrez S, Wang A, Lopez GV, Strander S, Kodali S, Silverman A, Zheng-Lin B, Dandapat S, Sansing LH, Schindler JL, Falcone GJ, Gilmore EJ, Amin H, Cord B, Hebert RM, Matouk C, Sheth KN. Decreases in Blood Pressure During Thrombectomy Are Associated With Larger Infarct Volumes and Worse Functional Outcome. Stroke 2019, 50: 1797-1804. PMID: 31159701, PMCID: PMC6787912, DOI: 10.1161/strokeaha.118.024286.Peer-Reviewed Original ResearchConceptsFinal infarct volumeWorse functional outcomeInfarct volumeEndovascular thrombectomyFunctional outcomeOcclusion strokeCerebral infarction 2b/3 reperfusionPressure reductionLarge vessel intracranial occlusionsGreater infarct growthBlood pressure reductionComprehensive stroke centerPercent of patientsBlood pressure managementLarger infarct volumesModified Rankin ScaleRankin Scale scoreMultivariable logistic regressionRelative hypotensionSustained hypotensionInfarct progressionNinety patientsInfarct growthIschemic penumbraIschemic stroke
2018
Cardioembolic Stroke Risk and Recovery After Anticoagulation-Related Intracerebral Hemorrhage
Murphy MP, Kuramatsu JB, Leasure A, Falcone GJ, Kamel H, Sansing LH, Kourkoulis C, Schwab K, Elm JJ, Gurol ME, Tran H, Greenberg SM, Viswanathan A, Anderson CD, Schwab S, Rosand J, Shi FD, Kittner SJ, Testai FD, Woo D, Langefeld CD, James ML, Koch S, Huttner HB, Biffi A, Sheth KN. Cardioembolic Stroke Risk and Recovery After Anticoagulation-Related Intracerebral Hemorrhage. Stroke 2018, 49: 2652-2658. PMID: 30355194, PMCID: PMC6211810, DOI: 10.1161/strokeaha.118.021799.Peer-Reviewed Original ResearchConceptsCardioembolic stroke riskOral anticoagulation therapyRankin Scale scoreIntracerebral hemorrhageFunctional recoveryStroke riskAnticoagulation resumptionVASc scoreRecurrent strokeAnticoagulation therapyScale scoreAnticoagulation-related intracerebral hemorrhageDecreased likelihoodSurvivors of ICHModified Rankin Scale scoreNonvalvular atrial fibrillationRecurrent intracerebral hemorrhageOral anticoagulation treatmentICH survivorsTherapy resumptionAnticoagulation treatmentCardioembolic strokeIschemic strokeAtrial fibrillationIndex eventSafety Outcomes of Thrombolysis for Acute Ischemic Stroke in Patients with History of Intracranial Hemorrhage (P4.033)
Chu S, Sommaruga S, Hwang D, Dearborn J, Sansing L, Cord B, Samarth G, Petersen N, Gilmore E, Schindler J, Matouk C, Sheth K, Falcone G. Safety Outcomes of Thrombolysis for Acute Ischemic Stroke in Patients with History of Intracranial Hemorrhage (P4.033). Neurology 2018, 90 DOI: 10.1212/wnl.90.15_supplement.p4.033.Peer-Reviewed Original Research
2016
Endovascular Stroke Treatment Outcomes After Patient Selection Based on Magnetic Resonance Imaging and Clinical Criteria
Leslie-Mazwi TM, Hirsch JA, Falcone GJ, Schaefer PW, Lev MH, Rabinov JD, Rost NS, Schwamm L, González RG. Endovascular Stroke Treatment Outcomes After Patient Selection Based on Magnetic Resonance Imaging and Clinical Criteria. JAMA Neurology 2016, 73: 1-7. PMID: 26524074, DOI: 10.1001/jamaneurol.2015.3000.Peer-Reviewed Original ResearchConceptsMagnetic resonance imagingSelection of patientsClinical criteriaFavorable outcomeSuccessful reperfusionMRS scoreLTB patientsIschemic strokeTerminal internal carotid artery occlusionResonance imagingInternal carotid artery occlusionStroke treatment outcomesEndovascular stroke treatmentAcute ischemic strokeCarotid artery occlusionProspective cohort studyMiddle cerebral arterySpecific magnetic resonance imagingInfarct volume determinationArtery occlusionCohort studyStroke treatmentCerebral arteryEndovascular treatmentPatient selection
2015
Common variation in COL4A1/COL4A2 is associated with sporadic cerebral small vessel disease
Rannikmäe K, Davies G, Thomson PA, Bevan S, Devan WJ, Falcone GJ, Traylor M, Anderson CD, Battey TW, Radmanesh F, Deka R, Woo JG, Martin LJ, Jimenez-Conde J, Selim M, Brown DL, Silliman SL, Kidwell CS, Montaner J, Langefeld CD, Slowik A, Hansen BM, Lindgren AG, Meschia JF, Fornage M, Bis JC, Debette S, Ikram MA, Longstreth WT, Schmidt R, Zhang CR, Yang Q, Sharma P, Kittner SJ, Mitchell BD, Holliday EG, Levi CR, Attia J, Rothwell PM, Poole DL, Boncoraglio GB, Psaty BM, Malik R, Rost N, Worrall BB, Dichgans M, Van Agtmael T, Woo D, Markus HS, Seshadri S, Rosand J, Sudlow CL. Common variation in COL4A1/COL4A2 is associated with sporadic cerebral small vessel disease. Neurology 2015, 84: 918-926. PMID: 25653287, PMCID: PMC4351667, DOI: 10.1212/wnl.0000000000001309.Peer-Reviewed Original ResearchConceptsDeep intracerebral hemorrhageSmall vessel diseaseCerebral small vessel diseaseIntracerebral hemorrhageWhite matter hyperintensitiesVessel diseaseIschemic strokeSingle nucleotide polymorphismsMatter hyperintensitiesSymptomatic small vessel diseaseSporadic cerebral small vessel diseaseWhite matter hyperintensity volumeLacunar ischemic strokeIschemic stroke patientsPopulation-based studySymptomatic ischemic stroke patientsCOL4A1/COL4A2Common single nucleotide polymorphismsDirection of associationCommon variationStroke patientsHyperintensity volumeSporadic formsHemorrhageCerebrovascular phenotypes