2019
Treatment of Hypertension in Complex Older Adults: How Many Medications Are Needed?
Ouellet GM, McAvay G, Murphy TE, Tinetti ME. Treatment of Hypertension in Complex Older Adults: How Many Medications Are Needed? Gerontology And Geriatric Medicine 2019, 5: 2333721419856436. PMID: 31245434, PMCID: PMC6580710, DOI: 10.1177/2333721419856436.Peer-Reviewed Original ResearchMajor adverse cardiovascular eventsMedical Expenditure Panel SurveyAntihypertensive classesCardiovascular eventsOlder adultsMultivariable proportional hazards regressionAdverse cardiovascular eventsProportional hazards regressionGreater cardiovascular benefitTreatment of hypertensionComplex older adultsRisk of mortalityRepresentative community sampleAdditional antihypertensivesMultiple antihypertensivesHypertensive adultsCardiovascular benefitsHazards regressionExposure groupRepresentative cohortMobility disabilityInverse probabilityLongitudinal associationsHypertensionAdults
2018
Principle of rational prescribing and deprescribing in older adults with multiple chronic conditions
Ouellet GM, Ouellet JA, Tinetti ME. Principle of rational prescribing and deprescribing in older adults with multiple chronic conditions. Therapeutic Advances In Drug Safety 2018, 9: 639-652. PMID: 30479739, PMCID: PMC6243421, DOI: 10.1177/2042098618791371.Peer-Reviewed Original ResearchMultiple chronic conditionsOptimal treatment regimensTreatment regimensOlder adultsChronic conditionsClinical trajectoriesMedication-related harmPatient's own prioritiesPatient's clinical trajectoryOptimal prescribingTherapeutic trialsPrescribed medicationsClinical statusHealth outcome goalsHealthy patientsRational prescribingPatient goalsClinical trialsPatient prioritiesPatientsSignificant burdenRegimensAdverse effectsAdultsLess benefit