2007
Autoimmunity in HLA-DQ8 transgenic mice expressing granulocyte/macrophage-colony stimulating factor in the beta cells of islets of langerhans
Rajagopalan G, Mangalam A, Sen M, Cheng S, Kudva Y, David C. Autoimmunity in HLA-DQ8 transgenic mice expressing granulocyte/macrophage-colony stimulating factor in the beta cells of islets of langerhans. Autoimmunity 2007, 40: 169-179. PMID: 17453715, DOI: 10.1080/08916930701201083.Peer-Reviewed Original ResearchConceptsHLA-DQ8GM-CSFDQ8 miceAutoimmune diabetesHLA-DQ8 transgenic miceMarked mononuclear cell infiltrationPotent immunostimulatory cytokineSpontaneous autoimmune diabetesMononuclear cell infiltrationNOD genetic backgroundGranulocyte/macrophage-colony stimulating factorStrong HLA associationType 1 diabetesPolygenic autoimmune diseasesMacrophage-colony stimulating factorLiver of miceMacrophage colony-stimulating factorGranulocyte/macrophage colony-stimulating factorColony-stimulating factorHLA associationsImmunostimulatory cytokinesAutoimmune diseasesCell infiltrationBeta cellsTransgenic mice
2002
Expression and Function of Transgenic HLA-DQ Molecules and Lymphocyte Development in Mice Lacking Invariant Chain
Rajagopalan G, Smart M, Krco C, David C. Expression and Function of Transgenic HLA-DQ Molecules and Lymphocyte Development in Mice Lacking Invariant Chain. The Journal Of Immunology 2002, 169: 1774-1783. PMID: 12165499, DOI: 10.4049/jimmunol.169.4.1774.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAntigen PresentationAntigensAntigens, Differentiation, B-LymphocyteB-LymphocytesCD4-Positive T-LymphocytesCD8-Positive T-LymphocytesCell DifferentiationCytoskeletal ProteinsEnterotoxinsGene ExpressionHistocompatibility Antigens Class IIHLA-DQ AntigensHumansIn Vitro TechniquesInterferon-gammaLymphocyte ActivationLymphocyte SubsetsMiceMice, Inbred BALB CMice, Inbred C57BLMice, KnockoutMice, TransgenicShock, SepticConceptsClass II moleculesStaphylococcal enterotoxin BMHC class II moleculesT cellsFunctional MHC class II moleculesSystemic IFN-gamma productionT cell responsesHuman class II moleculesIFN-gamma productionPrimed T cellsHLA-DQ moleculesInvariant chainSpecific T cell hybridomasProcessing/presentationT cell hybridomasT cell developmentDQ8 miceExogenous superantigensHLA-DQ8Mature B cellsCytokine productionHLA-DQ6Phenotype of miceVivo challengeB cells