1987
Treatment of Lyme disease
Steere A, Green J, Hutchinson G, Rahn D, Pachner A, Schoen R, Sigal L, Taylor E, Malawista S. Treatment of Lyme disease. International Journal Of Medical Microbiology 1987, 263: 352-356. PMID: 3109144, DOI: 10.1016/s0176-6724(87)80092-5.Peer-Reviewed Original ResearchMeSH KeywordsAdultArthritis, InfectiousChildErythromycinHumansLyme DiseaseNervous System DiseasesPenicillin VRandom AllocationTetracyclineConceptsPenicillin-treated patientsLyme diseaseHigh-dose intravenous penicillinAttacks of arthritisIntravenous penicillin GHalf of patientsMajor late complicationsEarly Lyme diseaseIntramuscular benzathine penicillinIntravenous penicillinLate complicationsAntibiotic therapyArthritis patientsBenzathine penicillinMotor deficitsNeurologic abnormalitiesLate diseaseLate symptomsPatientsPhenoxymethyl penicillinAntibiotic agentsComplete recoveryDiseasePenicillin GArthritis
1985
Successful Parenteral Penicillin Therapy of Established Lyme Arthritis
Steere A, Green J, Schoen R, Taylor E, Hutchinson G, Rahn D, Malawista S. Successful Parenteral Penicillin Therapy of Established Lyme Arthritis. New England Journal Of Medicine 1985, 312: 869-874. PMID: 3883177, DOI: 10.1056/nejm198504043121401.Peer-Reviewed Original ResearchMeSH KeywordsAdultArthritis, InfectiousClinical Trials as TopicDouble-Blind MethodFemaleHumansInjections, IntravenousLyme DiseaseMalePenicillin GConceptsLyme arthritisComplete resolutionDouble-blind placebo-controlled trialAttacks of arthritisIntravenous penicillin GParenteral penicillin therapyPlacebo-controlled trialPenicillin-treated patientsErythema chronicum migransMean followPenicillin therapyParenteral therapyParenteral penicillinIntraarticular corticosteroidsJoint fluidArthritisPatientsLyme spirocheteFurther experienceTherapyPenicillin GOptimal courseDaysCorticosteroidsPlacebo
1983
Treatment of the early manifestations of Lyme disease.
Steere AC, Hutchinson GJ, Rahn DW, Sigal LH, Craft JE, DeSanna ET, Malawista SE. Treatment of the early manifestations of Lyme disease. Annals Of Internal Medicine 1983, 99: 22-6. PMID: 6407378, DOI: 10.7326/0003-4819-99-1-22.Peer-Reviewed Original ResearchConceptsEarly Lyme diseaseAdult patientsLyme diseaseMajor late complicationsPenicillin-treated patientsTetracycline-treated patientsAntibiotic regimensLate complicationsMajor complicationsMusculoskeletal painInitial severityLate symptomsEffective drugsPatientsEarly manifestationAntibiotic agentsComplicationsDiseaseSymptomsErythromycinPenicillinTetracyclinePainRegimensHeadacheThe early clinical manifestations of Lyme disease.
Steere AC, Bartenhagen NH, Craft JE, Hutchinson GJ, Newman JH, Rahn DW, Sigal LH, Spieler PN, Stenn KS, Malawista SE. The early clinical manifestations of Lyme disease. Annals Of Internal Medicine 1983, 99: 76-82. PMID: 6859726, DOI: 10.7326/0003-4819-99-1-76.Peer-Reviewed Original ResearchConceptsLyme diseaseSkin lesionsElevated serum IgM levelsMigratory musculoskeletal painTick-transmitted spirochetesUnique skin lesionAspartate transaminase levelsEarly clinical manifestationsEarly Lyme diseaseSerum IgM levelsErythema chronicum migransMeningeal irritationLaboratory abnormalitiesNonproductive coughTransaminase levelsUrticarial rashMusculoskeletal painRegional lymphadenopathySkin manifestationsSore throatDermatologic manifestationsSerologic testingClinical manifestationsIgM levelsPeriorbital edema