2024
Categorical and Dimensional Approaches for Psychiatric Classification and Treatment Targeting: Considerations from Psychosis Biotypes
Clementz B, Assaf M, Sweeney J, Gershon E, Keedy S, Hill S, Ivleva E, Tamminga C, McDowell J, Keshavan M, Gibbons R, Carpenter W, Pearlson G. Categorical and Dimensional Approaches for Psychiatric Classification and Treatment Targeting: Considerations from Psychosis Biotypes. Advances In Neurobiology 2024, 40: 685-723. PMID: 39562461, DOI: 10.1007/978-3-031-69491-2_23.Peer-Reviewed Original ResearchConceptsIdiopathic psychosisBiotype-1Response to clozapineBipolar-Schizophrenia NetworkContinuum of severityReduced physiological responseDSM diagnosesNeurobiological distinctionsCategorical diagnosisSchizophrenia NetworkDiagnostic boundariesSalient stimuliPsychosis diagnosisPsychosis casesPsychiatric classificationPsychosis dataPsychosisBiotype-2Identified biotypesNeural activityIntermediate phenotypesTreatment targetElectrophysiological biomarkersElectrophysiological measurementsMedical model
1986
Positron Emission Tomography Reveals Elevated D2 Dopamine Receptors in Drug-Naive Schizophrenics
Wong D, Wagner H, Tune L, Dannals R, Pearlson G, Links J, Tamminga C, Broussolle E, Ravert H, Wilson A, Toung J, Malat J, Williams J, O'Tuama L, Snyder S, Kuhar M, Gjedde A. Positron Emission Tomography Reveals Elevated D2 Dopamine Receptors in Drug-Naive Schizophrenics. Science 1986, 234: 1558-1563. PMID: 2878495, DOI: 10.1126/science.2878495.Peer-Reviewed Original ResearchConceptsD2 dopamine receptorsD2 dopamine receptor densityPositron emission tomographyGroup of patientsDopamine receptor densityDopamine receptorsCaudate nucleusReceptor densityNormal volunteersEmission tomographyDrug-naive schizophrenicsNumber of receptorsMost patientsBasal gangliaNeuroleptic drugsPostmortem studiesBiochemical abnormalitiesPatientsPsychiatric diseasesSchizophreniaReceptorsDrugsVolunteersTomographyGroup
1980
Low neuroleptic serum levels in patients receiving fluphenazine decanoate
Tune L, Creese I, Coyle J, Pearlson G, Snyder S. Low neuroleptic serum levels in patients receiving fluphenazine decanoate. American Journal Of Psychiatry 1980, 137: 80-82. PMID: 6101523, DOI: 10.1176/ajp.137.1.80.Peer-Reviewed Original Research