2023
Emotional scene processing in biotypes of psychosis
Trotti R, Parker D, Sabatinelli D, Keshavan M, Keedy S, Gershon E, Pearlson G, Hill S, Tamminga C, McDowell J, Clementz B. Emotional scene processing in biotypes of psychosis. Psychiatry Research 2023, 324: 115227. PMID: 37121219, PMCID: PMC10175237, DOI: 10.1016/j.psychres.2023.115227.Peer-Reviewed Original ResearchConceptsSocial-emotional deficitsEmotional scenesSelf-reported emotional experienceEvent-related potential studyEmotional scene processingEmotional processing deficitsPsychosis groupPsychosis subgroupsSocio-occupational functioningEmotional processingProcessing deficitsScene processingEmotional experienceNeurophysiological correlatesNeural responsesPotential studiesScalp locationsPsychosis biotypesERPCurrent studyDeficitsFirst variateFuture translational researchPsychosisPsychosis casesPeripheral inflammation is associated with impairments of inhibitory behavioral control and visual sensorimotor function in psychotic disorders
Zhang L, Lizano P, Xu Y, Rubin L, Lee A, Lencer R, Reilly J, Keefe R, Keedy S, Pearlson G, Clementz B, Keshavan M, Gershon E, Tamminga C, Sweeney J, Hill S, Bishop J. Peripheral inflammation is associated with impairments of inhibitory behavioral control and visual sensorimotor function in psychotic disorders. Schizophrenia Research 2023, 255: 69-78. PMID: 36965362, PMCID: PMC10175233, DOI: 10.1016/j.schres.2023.03.030.Peer-Reviewed Original ResearchConceptsCognitive domainsInhibitory controlGeneral cognitive abilitySpecific cognitive domainsInhibitory behavioral controlC-reactive proteinPsychotic disordersPsychosis spectrum disordersCognitive abilitiesPeripheral inflammationInflammation factorsSpectrum disorderSensorimotor functionSensorimotor tasksNeurobehavioral domainsGreater deficitsSubgroup of individualsBehavioral controlPsychosis subgroupsCognitive impairmentPreliminary evidenceHigher inflammation scoresNeurobehavioral batteryBrain anatomyBehavioral monitoring
2020
O3.4. PSYCHOSIS PHENOTYPES FROM B-SNIP FOR CLINICAL ADVANCES: BIOTYPE CHARACTERISTICS AND TARGETS
Clementz B, Trotti R, Pearlson G, Keshavan M, Gershon E, Keedy S, Ivleva E, McDowell J, Tamminga C. O3.4. PSYCHOSIS PHENOTYPES FROM B-SNIP FOR CLINICAL ADVANCES: BIOTYPE CHARACTERISTICS AND TARGETS. Schizophrenia Bulletin 2020, 46: s7-s7. PMCID: PMC7234003, DOI: 10.1093/schbul/sbaa028.015.Peer-Reviewed Original ResearchClinical featuresPsychosis biotypesPsychosis casesPsychosis syndromeTreatment targetsSpecific treatment targetsB-SNIPClinical manifestationsBiomarker profilesPsychosis subgroupsB-SNIP consortiumDeep phenotyping approachPathophysiological mechanismsPsychosis patientsBipolar-Schizophrenia NetworkPsychosis diagnosisBiological subtypesHealthy personsClinical practiceClinical advancesNegative symptomsClinical phenomenologySyndrome
2019
Intrinsic neural activity differences in psychosis biotypes: Findings from the Bipolar-Schizophrenia Network on Intermediate Phenotypes (B-SNIP) consortium
Thomas O, Parker D, Trotti R, McDowell J, Gershon E, Sweeney J, Keshavan M, Keedy S, Ivleva E, Tamminga C, Pearlson G, Clementz B. Intrinsic neural activity differences in psychosis biotypes: Findings from the Bipolar-Schizophrenia Network on Intermediate Phenotypes (B-SNIP) consortium. Biomarkers In Neuropsychiatry 2019, 1: 100002. PMID: 36643612, PMCID: PMC9837786, DOI: 10.1016/j.bionps.2019.100002.Peer-Reviewed Original ResearchPsychosis biotypesHealthy personsBipolar-Schizophrenia NetworkSingle-trial powerFirst-degree biological relativesNeural activity differencesInter-stimulus intervalBiotype 2Intermediate Phenotypes (B-SNIP) consortiumPsychosis casesEffective treatmentIntrinsic activityPsychosis subgroupsNeural modulationLow intrinsic activityDSM groupNeural activitySocial functioningBiotype characterizationBiological relativesConventional diagnosisIntermediate phenotypesDifferentiating featuresDSM syndromesProbands