2024
Categorical and Dimensional Approaches for Psychiatric Classification and Treatment Targeting: Considerations from Psychosis Biotypes
Clementz B, Assaf M, Sweeney J, Gershon E, Keedy S, Hill S, Ivleva E, Tamminga C, McDowell J, Keshavan M, Gibbons R, Carpenter W, Pearlson G. Categorical and Dimensional Approaches for Psychiatric Classification and Treatment Targeting: Considerations from Psychosis Biotypes. Advances In Neurobiology 2024, 40: 685-723. PMID: 39562461, DOI: 10.1007/978-3-031-69491-2_23.Peer-Reviewed Original ResearchConceptsIdiopathic psychosisBiotype-1Response to clozapineBipolar-Schizophrenia NetworkContinuum of severityReduced physiological responseDSM diagnosesNeurobiological distinctionsCategorical diagnosisSchizophrenia NetworkDiagnostic boundariesSalient stimuliPsychosis diagnosisPsychosis casesPsychiatric classificationPsychosis dataPsychosisBiotype-2Identified biotypesNeural activityIntermediate phenotypesTreatment targetElectrophysiological biomarkersElectrophysiological measurementsMedical modelEvidence from comprehensive independent validation studies for smooth pursuit dysfunction as a sensorimotor biomarker for psychosis
Meyhoefer I, Sprenger A, Derad D, Grotegerd D, Leenings R, Leehr E, Breuer F, Surmann M, Rolfes K, Arolt V, Romer G, Lappe M, Rehder J, Koutsouleris N, Borgwardt S, Schultze-Lutter F, Meisenzahl E, Kircher T, Keedy S, Bishop J, Ivleva E, McDowell J, Reilly J, Hill S, Pearlson G, Tamminga C, Keshavan M, Gershon E, Clementz B, Sweeney J, Hahn T, Dannlowski U, Lencer R. Evidence from comprehensive independent validation studies for smooth pursuit dysfunction as a sensorimotor biomarker for psychosis. Scientific Reports 2024, 14: 13859. PMID: 38879556, PMCID: PMC11180169, DOI: 10.1038/s41598-024-64487-6.Peer-Reviewed Original ResearchConceptsSmooth pursuit eye movementsPsychosis syndromePursuit eye movementsNon-psychotic bipolar disorderNon-psychotic affective disorderEye movementsSmooth pursuit dysfunctionMultivariate pattern analysisHealthy controlsPsychiatric sampleNeurobiological markersPsychosis probandsPsychotic syndromesAffective disordersPsychosis researchBipolar disorderPsychosis statusPsychosisSensorimotor functionSensorimotor measuresIndividual levelSensorimotor dysfunctionSensorimotorDisordersPattern analysis383. Symptom Severity for Psychosis Biotype 3 Shows Unique Associations With Environmental Exposures as Measured By the Exposome Score for Schizophrenia
Kromenacker B, Yassin W, Clementz B, Keshavan M, Ivleva E, Gershon E, McDowell J, Keedy S, Pearlson G, Hill S, Tamminga C. 383. Symptom Severity for Psychosis Biotype 3 Shows Unique Associations With Environmental Exposures as Measured By the Exposome Score for Schizophrenia. Biological Psychiatry 2024, 95: s256-s257. DOI: 10.1016/j.biopsych.2024.02.882.Peer-Reviewed Original ResearchAccelerating Medicines Partnership® Schizophrenia (AMP® SCZ): Rationale and Study Design of the Largest Global Prospective Cohort Study of Clinical High Risk for Psychosis
Wannan C, Nelson B, Addington J, Allott K, Anticevic A, Arango C, Baker J, Bearden C, Billah T, Bouix S, Broome M, Buccilli K, Cadenhead K, Calkins M, Cannon T, Cecci G, Chen E, Cho K, Choi J, Clark S, Coleman M, Conus P, Corcoran C, Cornblatt B, Diaz-Caneja C, Dwyer D, Ebdrup B, Ellman L, Fusar-Poli P, Galindo L, Gaspar P, Gerber C, Glenthøj L, Glynn R, Harms M, Horton L, Kahn R, Kambeitz J, Kambeitz-Ilankovic L, Kane J, Kapur T, Keshavan M, Kim S, Koutsouleris N, Kubicki M, Kwon J, Langbein K, Lewandowski K, Light G, Mamah D, Marcy P, Mathalon D, McGorry P, Mittal V, Nordentoft M, Nunez A, Pasternak O, Pearlson G, Perez J, Perkins D, Powers A, Roalf D, Sabb F, Schiffman J, Shah J, Smesny S, Spark J, Stone W, Strauss G, Tamayo Z, Torous J, Upthegrove R, Vangel M, Verma S, Wang J, Rossum I, Wolf D, Wolff P, Wood S, Yung A, Agurto C, Alvarez-Jimenez M, Amminger P, Armando M, Asgari-Targhi A, Cahill J, Carrión R, Castro E, Cetin-Karayumak S, Chakravarty M, Cho Y, Cotter D, D’Alfonso S, Ennis M, Fadnavis S, Fonteneau C, Gao C, Gupta T, Gur R, Gur R, Hamilton H, Hoftman G, Jacobs G, Jarcho J, Ji J, Kohler C, Lalousis P, Lavoie S, Lepage M, Liebenthal E, Mervis J, Murty V, Nicholas S, Ning L, Penzel N, Poldrack R, Polosecki P, Pratt D, Rabin R, Eichi H, Rathi Y, Reichenberg A, Reinen J, Rogers J, Ruiz-Yu B, Scott I, Seitz-Holland J, Srihari V, Srivastava A, Thompson A, Turetsky B, Walsh B, Whitford T, Wigman J, Yao B, Yuen H, Ahmed U, Byun A, Chung Y, Do K, Hendricks L, Huynh K, Jeffries C, Lane E, Langholm C, Lin E, Mantua V, Santorelli G, Ruparel K, Zoupou E, Adasme T, Addamo L, Adery L, Ali M, Auther A, Aversa S, Baek S, Bates K, Bathery A, Bayer J, Beedham R, Bilgrami Z, Birch S, Bonoldi I, Borders O, Borgatti R, Brown L, Bruna A, Carrington H, Castillo-Passi R, Chen J, Cheng N, Ching A, Clifford C, Colton B, Contreras P, Corral S, Damiani S, Done M, Estradé A, Etuka B, Formica M, Furlan R, Geljic M, Germano C, Getachew R, Goncalves M, Haidar A, Hartmann J, Jo A, John O, Kerins S, Kerr M, Kesselring I, Kim H, Kim N, Kinney K, Krcmar M, Kotler E, Lafanechere M, Lee C, Llerena J, Markiewicz C, Matnejl P, Maturana A, Mavambu A, Mayol-Troncoso R, McDonnell A, McGowan A, McLaughlin D, McIlhenny R, McQueen B, Mebrahtu Y, Mensi M, Hui C, Suen Y, Wong S, Morrell N, Omar M, Partridge A, Phassouliotis C, Pichiecchio A, Politi P, Porter C, Provenzani U, Prunier N, Raj J, Ray S, Rayner V, Reyes M, Reynolds K, Rush S, Salinas C, Shetty J, Snowball C, Tod S, Turra-Fariña G, Valle D, Veale S, Whitson S, Wickham A, Youn S, Zamorano F, Zavaglia E, Zinberg J, Woods S, Shenton M. Accelerating Medicines Partnership® Schizophrenia (AMP® SCZ): Rationale and Study Design of the Largest Global Prospective Cohort Study of Clinical High Risk for Psychosis. Schizophrenia Bulletin 2024, 50: 496-512. PMID: 38451304, PMCID: PMC11059785, DOI: 10.1093/schbul/sbae011.Peer-Reviewed Original ResearchClinical high-risk individualsClinical high riskNational Institute of Mental HealthInstitute of Mental HealthAttenuated positive symptomsPersistent negative symptomsTransition to psychosisCHR statusHigh riskNegative symptomsPositive symptomsAnxiety symptomsPsychosocial functioningCognitive dataOutcomes of individualsDigital health technologiesDaily surveysPsychosisSCZPublic health needsMental healthNovel pharmacological interventionsSchizophreniaClinical outcomesHealth needs
2023
Is There a Cannabis-Associated Psychosis Sub-type?
Pearlson G, Keshavan M. Is There a Cannabis-Associated Psychosis Sub-type? 2023, 91-106. DOI: 10.1017/9781108943246.011.Peer-Reviewed Original ResearchMental illnessMental health teamsHealth policy implicationsHigh-potency cannabisStages of neurodevelopmentPotential adverse effectsHealth teamsImpact of exposureCannabis dependenceAdverse effectsCannabisSynthetic cannabinoidsIllnessPsychosisCannabinoidsNew research findingsAssociationComplex associationPutative modelNeurodevelopmentSchizophreniaEmotional scene processing in biotypes of psychosis
Trotti R, Parker D, Sabatinelli D, Keshavan M, Keedy S, Gershon E, Pearlson G, Hill S, Tamminga C, McDowell J, Clementz B. Emotional scene processing in biotypes of psychosis. Psychiatry Research 2023, 324: 115227. PMID: 37121219, PMCID: PMC10175237, DOI: 10.1016/j.psychres.2023.115227.Peer-Reviewed Original ResearchConceptsSocial-emotional deficitsEmotional scenesSelf-reported emotional experienceEvent-related potential studyEmotional scene processingEmotional processing deficitsPsychosis groupPsychosis subgroupsSocio-occupational functioningEmotional processingProcessing deficitsScene processingEmotional experienceNeurophysiological correlatesNeural responsesPotential studiesScalp locationsPsychosis biotypesERPCurrent studyDeficitsFirst variateFuture translational researchPsychosisPsychosis cases
2021
Anterior-posterior axis of hippocampal subfields across psychoses: A B-SNIP study
del Re E, Zeng V, Alliey-Rodriguez N, Lizano P, Bolo N, Lutz O, Pearlson G, Sweeney J, Clementz B, Gershon E, Tamminga C, Keshavan M. Anterior-posterior axis of hippocampal subfields across psychoses: A B-SNIP study. Biomarkers In Neuropsychiatry 2021, 5: 100037. DOI: 10.1016/j.bionps.2021.100037.Peer-Reviewed Original ResearchVolumetric abnormalitiesPsychosis probandsBipolar type 1Granule cell layerT MRI scansB-SNIP studyB-SNIPDentate gyrusBipolar-Schizophrenia NetworkHealthy controlsClinical dataHippocampal subfieldsDSM categoriesMRI scansSchizoaffective disorderHippocampusType 1Schizophrenia NetworkAbnormalitiesUnaffected relativesAnterior-posterior axisSchizophreniaPsychosisProbandsConclusions DifferencesMorphometric Attention and Language Brain Correlates in Early Psychosis With Cannabis Use and Polygenic Risk Score: A BSNIP Study
Reed A, Zeng V, Alliey-Rodriguez N, Tamminga C, Clementz B, Pearlson G, Sweeney J, Gershon E, Keshavan M, del Re E. Morphometric Attention and Language Brain Correlates in Early Psychosis With Cannabis Use and Polygenic Risk Score: A BSNIP Study. Biological Psychiatry 2021, 89: s242-s243. DOI: 10.1016/j.biopsych.2021.02.608.Peer-Reviewed Original Research
2020
Auditory paired-stimuli responses across the psychosis and bipolar spectrum and their relationship to clinical features
Parker D, Trotti R, McDowell J, Keedy S, Gershon E, Ivleva E, Pearlson G, Keshavan M, Tamminga C, Sweeney J, Clementz B. Auditory paired-stimuli responses across the psychosis and bipolar spectrum and their relationship to clinical features. Biomarkers In Neuropsychiatry 2020, 3: 100014. PMID: 36644018, PMCID: PMC9837793, DOI: 10.1016/j.bionps.2020.100014.Peer-Reviewed Original ResearchSchizoaffective disorderGroup differencesBipolar disorderAuditory paired-stimulus paradigmPaired-stimulus paradigmNeural responsesIdentification of biomarkersB-SNIPClinical featuresSignificant group differencesPsychosis subjectsBipolar-Schizophrenia NetworkPsychosis casesHealthy subjectsPreparatory periodPsychosis syndromeFrequency principal components analysisMania symptomsP50 responsePositive symptomsClinical phenotypeAffective syndromeBipolar spectrumPsychosisPutative biomarkersNeuroanatomical Sex Differences in the Visual Cortex of Individuals With Psychosis: Findings From the Bipolar-Schizophrenia Network on Intermediate Phenotypes
Turkozer H, Lizano P, Adhan I, Ivleva E, Lutz O, Zeng A, Raymond N, Clementz B, Pearlson G, Sweeney J, Gershon E, Keshavan M, Tamminga C. Neuroanatomical Sex Differences in the Visual Cortex of Individuals With Psychosis: Findings From the Bipolar-Schizophrenia Network on Intermediate Phenotypes. Biological Psychiatry 2020, 87: s205. DOI: 10.1016/j.biopsych.2020.02.533.Peer-Reviewed Original ResearchTrauma in Affective and Nonaffective Psychosis: Associations and Dissociations With Cognitive Functioning in Childhood and Adulthood
Mollon J, Mathias S, Knowles E, Rodrigue A, Pearlson G, Barrett J, Poldrack R, Blangero J, Glahn D. Trauma in Affective and Nonaffective Psychosis: Associations and Dissociations With Cognitive Functioning in Childhood and Adulthood. Biological Psychiatry 2020, 87: s458. DOI: 10.1016/j.biopsych.2020.02.1165.Peer-Reviewed Original ResearchChapter 6 Psychology + human behavior
Pearlson G. Chapter 6 Psychology + human behavior. 2020, 101-134. DOI: 10.1016/b978-0-12-818174-4.00006-9.Peer-Reviewed Original ResearchSense of selfDrug's long-term effectsPsychological phenomenaBrain circuitsCannabis useHuman behaviorLong-term effectsMental functionsEveryday examplesDrug-induced alterationsCannabisPsychologyIQDrug effectsRecreational drugsMoodFeelingsMarijuanaPsychedelicsSelfEcstasyBehaviorPsychosisConsciousnessCannabinoid receptors
2019
11.2 PUPILLOMETER-BASED NEUROFEEDBACK COGNITIVE TRAINING: OPTIMIZING TASK ENGAGEMENT TO ENHANCE LEARNING IN PRODROME, FIRST EPISODE, AND ESTABLISHED PSYCHOSIS
Choi J, Fiszdon J, Stevens M, Haber L, Pearlson G. 11.2 PUPILLOMETER-BASED NEUROFEEDBACK COGNITIVE TRAINING: OPTIMIZING TASK ENGAGEMENT TO ENHANCE LEARNING IN PRODROME, FIRST EPISODE, AND ESTABLISHED PSYCHOSIS. Schizophrenia Bulletin 2019, 45: s104-s105. PMCID: PMC6455325, DOI: 10.1093/schbul/sbz022.040.Peer-Reviewed Original Research