2024
Double Functionally Independent Primitives Provide Disorder Specific Fingerprints of Mental Illnesses
Soleimani N, Pearlson G, Iraji A, Calhoun V. Double Functionally Independent Primitives Provide Disorder Specific Fingerprints of Mental Illnesses. 2024, 00: 1-4. DOI: 10.1109/isbi56570.2024.10635116.Peer-Reviewed Original ResearchAutism spectrum disorderMental illnessBipolar disorderMental disordersManifestations of mental illnessAssociated with mental illnessFunctional network connectivityFunctional network connectivity patternsNetwork connectivity patternsDisorder-specificDepressive disorderNeural underpinningsSpectrum disorderPsychological disordersNeuroimaging techniquesConnectivity patternsDisordersSchizophreniaHealthy controlsIllnessBrainFunctional changesMDDAutismNetwork connectivity
2023
Is There a Cannabis-Associated Psychosis Sub-type?
Pearlson G, Keshavan M. Is There a Cannabis-Associated Psychosis Sub-type? 2023, 91-106. DOI: 10.1017/9781108943246.011.Peer-Reviewed Original ResearchMental illnessMental health teamsHealth policy implicationsHigh-potency cannabisStages of neurodevelopmentPotential adverse effectsHealth teamsImpact of exposureCannabis dependenceAdverse effectsCannabisSynthetic cannabinoidsIllnessPsychosisCannabinoidsNew research findingsAssociationComplex associationPutative modelNeurodevelopmentSchizophreniaCharacterization of the extracellular free water signal in schizophrenia using multi-site diffusion MRI harmonization
Cetin-Karayumak S, Lyall A, Di Biase M, Seitz-Holland J, Zhang F, Kelly S, Elad D, Pearlson G, Tamminga C, Sweeney J, Clementz B, Schretlen D, Stegmayer K, Walther S, Lee J, Crow T, James A, Voineskos A, Buchanan R, Szeszko P, Malhotra A, Keshavan M, Shenton M, Rathi Y, Pasternak O, Kubicki M. Characterization of the extracellular free water signal in schizophrenia using multi-site diffusion MRI harmonization. Molecular Psychiatry 2023, 28: 2030-2038. PMID: 37095352, PMCID: PMC11146151, DOI: 10.1038/s41380-023-02068-1.Peer-Reviewed Original ResearchDuration of illnessIllness stageHealthy controlsWhole brain white matterDifferent illness stagesFree-water imagingSchizophrenia spectrum disordersYounger patientsBrain white matterExtracellular free waterProlonged illnessEarly psychosisDiffusion magnetic resonanceWhite matterDemographic dataIllnessSchizophreniaSmall effect sizesShort durationTime courseAgeEffect sizeSignificant global increaseInternational sitesDisorders
2020
Chapter 10 Medical marijuana and clinical trials
Pearlson G. Chapter 10 Medical marijuana and clinical trials. 2020, 243-260. DOI: 10.1016/b978-0-12-818174-4.00010-0.Peer-Reviewed Original Research
2019
31.1 COMBINING EXERCISE PHYSIOLOGY, RECREATIONAL THERAPY, VIRTUAL REALITY GAMING TECHNOLOGY, AND PSYCHOSOCIAL REHABILITATION TO PROMOTE PHYSICAL EXERCISE IN SERIOUS MENTAL ILLNESS
Choi J, Taylor B, Fiszdon J, Astur R, Haber L, Shagan D, Tek C, Kurtz M, Pearlson G. 31.1 COMBINING EXERCISE PHYSIOLOGY, RECREATIONAL THERAPY, VIRTUAL REALITY GAMING TECHNOLOGY, AND PSYCHOSOCIAL REHABILITATION TO PROMOTE PHYSICAL EXERCISE IN SERIOUS MENTAL ILLNESS. Schizophrenia Bulletin 2019, 45: s139-s140. PMCID: PMC6455379, DOI: 10.1093/schbul/sbz022.127.Peer-Reviewed Original Research
2017
Construction and Analysis of Weighted Brain Networks from SICE for the Study of Alzheimer's Disease
Munilla J, Ortiz A, Górriz J, Ramírez J, Initiative T, Weiner M, Aisen P, Weiner M, Aisen P, Petersen R, Jack C, Jagust W, Trojanowki J, Toga A, Beckett L, Green R, Saykin A, Morris J, Shaw L, Khachaturian Z, Sorensen G, Carrillo M, Kuller L, Raichle M, Paul S, Davies P, Fillit H, Hefti F, Holtzman D, Mesulam M, Potter W, Snyder P, Schwartz A, Green R, Montine T, Petersen R, Aisen P, Thomas R, Donohue M, Walter S, Gessert D, Sather T, Jiminez G, Balasubramanian A, Mason J, Sim I, Beckett L, Harvey D, Donohue M, Jack C, Bernstein M, Fox N, Thompson P, Schuff N, DeCArli C, Borowski B, Gunter J, Senjem M, Vemuri P, Jones D, Kantarci K, Ward C, Jagust W, Koeppe R, Foster N, Reiman E, Chen K, Mathis C, Landau S, Morris J, Cairns N, Franklin E, Taylor-Reinwald L, Shaw L, Trojanowki J, Lee V, Korecka M, Figurski M, Toga A, Crawford K, Neu S, Saykin A, Foroud T, Potkin S, Shen L, Faber K, Kim S, Nho K, Weiner M, Thal L, Khachaturian Z, Thal L, Buckholtz N, Weiner M, Snyder P, Potter W, Paul S, Albert M, Frank R, Khachaturian Z, Hsiao J, Kaye J, Quinn J, Silbert L, Lind B, Carter R, Dolen S, Schneider L, Pawluczyk S, Becerra M, Teodoro L, Spann B, Brewer J, Vanderswag H, Fleisher A, Heidebrink J, Lord J, Petersen R, Mason S, Albers C, Knopman D, Johnson K, Doody R, Villanueva-Meyer J, Pavlik V, Shibley V, Chowdhury M, Rountree S, Dang M, Stern Y, Honig L, Bell K, Ances B, Morris J, Carroll M, Creech M, Franklin E, Mintun M, Schneider S, Oliver A, Marson D, Geldmacher D, Love M, Griffith R, Clark D, Brockington J, Roberson E, Grossman H, Mitsis E, Shah R, deToledo-Morrell L, Duara R, Greig-Custo M, Barker W, Albert M, Onyike C, D'Agostino D, Kielb S, Sadowski M, Sheikh M, Anaztasia U, Mrunalini G, Doraiswamy P, Petrella J, Borges-Neto S, Wong T, Coleman E, Arnold S, Karlawish J, Wolk D, Clark C, Smith C, Jicha G, Hardy P, Sinha P, Oates E, Conrad G, Lopez O, Oakley M, Simpson D, Porsteinsson A, Goldstein B, Martin K, Makino K, Ismail M, Brand C, Potkin S, Preda A, Nguyen D, Womack K, Mathews D, Quiceno M, Levey A, Lah J, Cellar J, Burns J, Swerdlow R, Brooks W, Apostolova L, Tingus K, Woo E, Silverman D, Lu P, Bartzokis G, Graff-Radford N, Parfitt F, Poki-Walker K, Farlow M, Hake A, Matthews B, Brosch J, Herring S, van Dyck C, Carson R, MacAvoy M, Varma P, Chertkow H, Bergman H, Hosein C, Black S, Stefanovic B, Caldwell C, Hsiung G, Mudge B, Sossi V, Feldman H, Assaly M, Finger E, Pasternack S, Rachisky I, Trost D, Kertesz A, Bernick C, Munic D, Mesulam M, Rogalski E, Lipowski K, Weintraub S, Bonakdarpour B, Kerwin D, Wu C, Johnson N, Sadowsky C, Villena T, Turner R, Johnson K, Reynolds B, Sperling R, Johnson K, Marshall G, Yesavage J, Taylor J, Lane B, Rosen A, Tinklenberg J, Sabbagh M, Belden C, Jacobson S, Sirrel S, Kowall N, Killiany R, Budson A, Norbash A, Johnson P, Obisesan T, Wolday S, Allard J, Lerner A, Ogrocki P, Tatsuoka C, Fatica P, Fletcher E, Maillard P, Olichney J, DeCarli C, Carmichael O, Kittur S, Borrie M, Lee T, Bartha R, Johnson S, Asthana S, Carlsson C, Potkin S, Preda A, Nguyen D, Tariot P, Burke A, Milliken A, Trncic N, Fleisher A, Reeder S, Bates V, Capote H, Rainka M, Scharre D, Kataki M, Kelley B, Zimmerman E, Celmins D, Brown A, Pearlson G, Blank K, Anderson K, Flashman L, Seltzer M, Hynes M, Santulli R, Sink K, Leslie G, Williamson J, Garg P, Watkins F, Ott B, Tremont G, Daiello L, Salloway S, Malloy P, Correia S, Rosen H, Miller B, Perry D, Mintzer J, Spicer K, Bachman D, Finger E, Pasternak S, Rachinsky I, Rogers J, Kertesz A, Drost D, Pomara N, Hernando R, Sarrael A, Schultz S, Smith K, Koleva H, Nam K, Shim H, Relkin N, Chiang G, Lin M, Ravdin L, Smith A, Raj B, Fargher K, Weiner M, Aisen P, Weiner M, Aisen P, Petersen R, Green R, Harvey D, Jack C, Jagust W, Morris J, Saykin A, Shaw L, Toga A, Trojanowki J, Neylan T, Grafman J, Green R, Montine T, Weiner M, Petersen R, Aisen P, Thomas R, Donohue M, Devon G, Sather T, Melissa D, Morrison R, Jiminez G, Neylan T, Jacqueline H, Shannon F, Harvey D, Donohue M, Jack C, Bernstein M, Borowski B, Gunter J, Senjem M, Kejal K, Chad W, Jagust W, Koeppe R, Foster N, Reiman E, Chen K, Landau S, Morris J, Cairns N, Householder E, Shaw L, Trojanowki J, Lee V, Korecka M, Figurski M, Toga A, Karen C, Scott N, Saykin A, Foroud T, Potkin S, Shen L, Faber K, Kim S, Nho K, Weiner M, Karl F, Schneider L, Pawluczyk S, Mauricio B, Brewer J, Vanderswag H, Stern Y, Honig L, Bell K, Fleischman D, Arfanakis K, Shah R, Duara R, Varon D, Greig M, Doraiswamy P, Petrella J, James O, Porsteinsson A, Goldstein B, Martin K, Potkin S, Preda A, Nguyen D, Mintzer J, Massoglia D, Brawman-Mintzer O, Sadowsky C, Martinez W, Villena T, Jagust W, Landau S, Rosen H, Perry D, Turner R, Behan K, Reynolds B, Sperling R, Johnson K, Marshall G, Sabbagh M, Jacobson S, Sirrel S, Obisesan T, Wolday S, Allard J, Johnson S, Fruehling J, Harding S, Peskind E, Petrie E, Li G, Yesavage J, Taylor J, Furst A, Chao S, Relkin N, Chiang G, Ravdin L, Ravdin L. Construction and Analysis of Weighted Brain Networks from SICE for the Study of Alzheimer's Disease. Frontiers In Neuroinformatics 2017, 11: 19. PMID: 28344551, PMCID: PMC5344925, DOI: 10.3389/fninf.2017.00019.Peer-Reviewed Original ResearchPositron emission tomographyAlzheimer's diseaseNumber of subjectsConnectivity patternsCommon neurodegenerative diseaseMore effective treatmentsFunctional connectivity patternsSparse inverse covariance estimatesNeurodegenerative processesEffective treatmentBrain areasControl groupCurrent drugsBrain regionsEmission tomographyDiseaseNeurodegenerative diseasesSmall sample sizeElderly peopleEfficiency of drugsNatural aging processDiscriminant valueBrain networksIllnessBrain
1999
Structural and functional brain changes in bipolar disorder: a selective review
Pearlson G. Structural and functional brain changes in bipolar disorder: a selective review. Schizophrenia Research 1999, 39: 133-140. PMID: 10507524, DOI: 10.1016/s0920-9964(99)00112-7.Peer-Reviewed Original Research
1993
D2 receptor estimates in chronic schizophrenia reveal significant effects of age, sex, duration of illness
Tune L, Wong D, Pearlson G. D2 receptor estimates in chronic schizophrenia reveal significant effects of age, sex, duration of illness. Schizophrenia Research 1993, 9: 211-212. DOI: 10.1016/0920-9964(93)90456-s.Peer-Reviewed Original Research
1991
Physostigmine in Alzheimer's disease: effects on cognitive functioning, cerebral glucose metabolism analyzed by positron emission tomography and cerebral blood flow analyzed by single photon emission tomography
Tune L, Brandt J, Frost J, Harris G, Mayberg H, Steele C, Burns A, Sapp J, Folstein M, Wagner H, Pearlson G. Physostigmine in Alzheimer's disease: effects on cognitive functioning, cerebral glucose metabolism analyzed by positron emission tomography and cerebral blood flow analyzed by single photon emission tomography. Acta Psychiatrica Scandinavica. Supplementum 1991, 83: 61-65. PMID: 1897377, DOI: 10.1111/j.1600-0447.1991.tb03111.x.Peer-Reviewed Original ResearchMeSH KeywordsAgedAlzheimer DiseaseAmphetaminesBlood GlucoseBrainCerebrovascular CirculationDeoxyglucoseDose-Response Relationship, DrugDrug Administration ScheduleFemaleFluorodeoxyglucose F18HumansMaleMiddle AgedNeuropsychological TestsPhysostigminePilot ProjectsTomography, Emission-ComputedTomography, Emission-Computed, Single-PhotonConceptsCerebral glucose metabolismCerebral blood flowSingle photon emission tomographyPhoton emission tomographyPositron emission tomographyBlood flowEmission tomographyGlucose metabolismAlzheimer's diseaseRegional cerebral glucose metabolismSignificant clinical improvementCognitive functioningClinical improvementMost patientsIntravenous administrationPatientsDiseasePhysostigmineTomographyBrain activityPreliminary findingsMetabolismPronounced improvementPathophysiologyIllness
1988
The Late-Onset Psychoses Possible Risk Factors
Pearlson G, Rabins P. The Late-Onset Psychoses Possible Risk Factors. Psychiatric Clinics Of North America 1988, 11: 15-32. PMID: 3288978, DOI: 10.1016/s0193-953x(18)30514-8.Peer-Reviewed Original ResearchLate-Onset Schizophrenia Studying Clinical Validity
V.Jeste D, Harris M, Pearlson G, Rabins P, Lesser I, Miller B, Coles C, Yassa R. Late-Onset Schizophrenia Studying Clinical Validity. Psychiatric Clinics Of North America 1988, 11: 1-13. PMID: 3380754, DOI: 10.1016/s0193-953x(18)30513-6.Peer-Reviewed Original ResearchConceptsLate-onset schizophreniaSchizophrenic patientsYoung schizophrenic patientsClinical characteristicsChronic courseAge 45Onset schizophreniaParanoid typeClinical validityAuditory hallucinationsLow dosesBizarre delusionsSchizophreniaPatientsRelevant literatureNeurolepticsIllnessDosesHallucinations