2000
Rate of caudate atrophy in presymptomatic and symptomatic stages of Huntington's disease
Aylward E, Codori A, Rosenblatt A, Sherr M, Brandt J, Stine O, Barta P, Pearlson G, Ross C. Rate of caudate atrophy in presymptomatic and symptomatic stages of Huntington's disease. Movement Disorders 2000, 15: 552-560. PMID: 10830423, DOI: 10.1002/1531-8257(200005)15:3<552::aid-mds1020>3.0.co;2-p.Peer-Reviewed Original ResearchConceptsUseful outcome measureCaudate volumeHuntington's diseaseSymptomatic patientsSymptomatic subjectsCaudate atrophyOutcome measuresLongitudinal changesStages of HDMean interscan intervalSerial magnetic resonance imagesHD gene mutationNeurological examSymptomatic groupModerate symptomsMild symptomsSymptomatic stagePresymptomatic carriersTherapeutic studiesTreatment effectivenessPatientsMagnetic resonance imagesDiseaseGene mutationsInterscan interval
1992
Putamen volume reduction on magnetic resonance imaging exceeds caudate changes in mild Huntington's disease
Harris G, Pearlson G, Peyser C, Aylward E, Roberts J, Barta P, Chase G, Folstein S. Putamen volume reduction on magnetic resonance imaging exceeds caudate changes in mild Huntington's disease. Annals Of Neurology 1992, 31: 69-75. PMID: 1531910, DOI: 10.1002/ana.410310113.Peer-Reviewed Original ResearchConceptsMild Huntington's diseaseBicaudate ratioCaudate atrophyHuntington's diseaseHD patientsControl subjectsCaudate volumePutamen volumeSex-matched control subjectsNeurological examination scoresPutamen volume reductionsCharacteristic pathological featuresModerate Huntington's diseaseMagnetic resonance imagingCaudate changesNeostriatal atrophyNeuronal lossNeuroradiological studiesComputerized image analysis systemPathological featuresGreater atrophyBrain abnormalitiesCaudate nucleusAtrophyPatients
1991
Suprasellar cistern measures as a reflection of dementia in Alzheimer's disease but not Huntington's disease
Aylward E, Karagiozis H, Pearlson G, Folstein M. Suprasellar cistern measures as a reflection of dementia in Alzheimer's disease but not Huntington's disease. Journal Of Psychiatric Research 1991, 25: 31-47. PMID: 1827501, DOI: 10.1016/0022-3956(91)90014-2.Peer-Reviewed Original ResearchConceptsAlzheimer's diseaseSuprasellar cisternDisease patientsAD patientsTemporal lobeCognitive statusHuntington's diseaseRespective age-matched controlsBasal forebrain areasAge-matched controlsHuntington's disease patientsForebrain areasEntorhinal cortexCognitive declinePatientsDiseaseBrain widthLobeHDStatusAtrophyDementiaPerceptual ratingsCortex
1988
BRAIN IMAGING WITH IODOAMPHETAMINE (IMP) IN PATIENTS WITH HUNTINGTON'S DISEASE (HD)
LaFrance N, Pearlson G, Folstein S, Cole P, Turek J, Kumar A, Bascom M, McDonald A, Folstein M, Wagner H. BRAIN IMAGING WITH IODOAMPHETAMINE (IMP) IN PATIENTS WITH HUNTINGTON'S DISEASE (HD). Clinical Nuclear Medicine 1988, 13: 392. DOI: 10.1097/00003072-198805000-00039.Peer-Reviewed Original ResearchEarly HD patientsMini-Mental StateHD patientsHuntington's diseaseNeurological examinationMini-Mental State scoresDuration of diseaseGenotype-positive individualsEarly Huntington's diseaseMental state scoresForamen of MonroPotential therapeutic interventionsNormal CTFirst manifestationPositive individualsMRI studiesPatientsPreclinical measuresTherapeutic interventionsIodoamphetamineIMP accumulationDiseaseBrain imagingState scoresSignificant decrement
1987
Olfactory Recognition: Differential Impairments in Early and Late Huntington's and Alzheimer's Diseases
Moberg P, Pearlson G, Speedie L, Lipsey J, Strauss M, Folstein S. Olfactory Recognition: Differential Impairments in Early and Late Huntington's and Alzheimer's Diseases. Journal Of Clinical And Experimental Neuropsychology 1987, 9: 650-664. PMID: 2961789, DOI: 10.1080/01688638708405208.Peer-Reviewed Original ResearchConceptsHuntington's diseaseOverall patient groupOlfactory brain regionsPatient groupAlzheimer groupSenile dementiaAlzheimer typeNormal controlsDisease processPatientsAlzheimer's diseaseBrain regionsCognitive deficitsHuntington's patientsGlobal impairmentDiseaseOlfactory discriminationOlfactory paradigmVisual performanceDifferential impairmentImpairmentDeficitsGroupOlfactory recognitionDementia
1982
CT scan and neuropsychological correlates of Alzheimer's Disease and Huntington's Disease
Veroff A, Pearlson G, Ahn H. CT scan and neuropsychological correlates of Alzheimer's Disease and Huntington's Disease. Brain And Cognition 1982, 1: 177-184. PMID: 6242676, DOI: 10.1016/0278-2626(82)90015-x.Peer-Reviewed Original ResearchConceptsDisease patientsAlzheimer's diseaseAlzheimer's disease patientsCT scan interpretationHuntington's disease patientsCT scan informationCT attenuation valuesClinical characteristicsPrimary neuropathologyDementia syndromesCT scanScan interpretationNormal agingDiseaseHuntington's diseaseAphasia subtypesNeuropsychological correlatesPatientsSignificant correlationDouble dissociationAttenuation valuesRecent studiesScan informationLobe densityNeuropathology