1997
Quantification of Neuroreceptors in the Living Human Brain
Wong *, Pearlson ‡, Tune ‡, Young *, Meltzer *, Dannals *, Ravert *, Reith *, Kuhar †, Gjedde ¶. Quantification of Neuroreceptors in the Living Human Brain. Cerebrovascular And Brain Metabolism Reviews 1997, 17: 331-342. PMID: 9119906, DOI: 10.1097/00004647-199703000-00010.Peer-Reviewed Original ResearchConceptsD2-like dopamine receptorsDrug-naive schizophrenic patientsDopamine receptorsSchizophrenic patientsIllness patientsPatient groupControl subjectsReceptor densityD2 dopamine receptor densityDrug-naive schizophreniaDopamine receptor densityLiving Human BrainBipolar affective illnessD2 dopamine receptorsQuantification of NeuroreceptorsPositron emission tomographyEffect of ageBrain uptakeAffective illnessBipolar illnessNonpsychotic patientsCaudate nucleusNormal controlsNormal volunteersPatients
1995
In Vivo D2 Dopamine Receptor Density in Psychotic and Nonpsychotic Patients With Bipolar Disorder
Pearlson G, Wong D, Tune L, Ross C, Chase G, Links J, Dannals R, Wilson A, Ravert H, Wagner H, DePaulo J. In Vivo D2 Dopamine Receptor Density in Psychotic and Nonpsychotic Patients With Bipolar Disorder. JAMA Psychiatry 1995, 52: 471-477. PMID: 7771917, DOI: 10.1001/archpsyc.1995.03950180057008.Peer-Reviewed Original ResearchConceptsSchizophrenic patientsBipolar disorderBmax valuesNonpsychotic patientsNormal controlsPsychotic symptomsPsychotic patientsAffective disordersPositron emission tomographic scansD2 dopamine receptor densityNeuroleptic-naive schizophrenic patientsPositron emission tomographic studiesDopamine receptor densityReceptor density valuesDSM-III criteriaPresent State ExaminationPresence of psychosisEmission tomographic studiesHigher Bmax valuesPsychotic bipolar disorderNeuroleptic medicationReceptor BmaxMood abnormalitiesReceptor valuesTomographic scan
1993
Dopamine receptor density measured by C-11 raclopride and NMSP in the same schizophrenic patients and normal subjects
Wong D, Tune L, Shaya E, Pearlson G, Yung B, Dannals R, Wilson A, Ravert H, Wagner H, Gjedde A. Dopamine receptor density measured by C-11 raclopride and NMSP in the same schizophrenic patients and normal subjects. Schizophrenia Research 1993, 9: 212. DOI: 10.1016/0920-9964(93)90458-u.Peer-Reviewed Original Research
1988
D2 DOPAMINE RECEPTORS IN TOURETTE'S SYNDROME AND MANIC DEPRESSIVE ILLNESS
Wong D, Singer H, Pearlson G, Tune L, Ross C, Villemagne V, Dannals R, Links J, Wilson A, Ravert H, Wagner H, Gjedde A. D2 DOPAMINE RECEPTORS IN TOURETTE'S SYNDROME AND MANIC DEPRESSIVE ILLNESS. Clinical Nuclear Medicine 1988, 13: 392. DOI: 10.1097/00003072-198805000-00040.Peer-Reviewed Original ResearchManic-depressive illnessTourette syndromeDepressive illnessPsychotic symptomsD2 dopamine receptor densityDrug-free patientsDopamine receptor densityGreater clinical severityD2 dopamine receptorsOral haloperidolFree patientsMotor abnormalitiesAntagonist haloperidolClinical severityTourette patientsDopamine receptorsReceptor densityParkinson's diseaseCommon treatmentPsychiatric disordersActive psychosisSyndromePatientsAdult subjectsBmax values
1986
Positron Emission Tomography Reveals Elevated D2 Dopamine Receptors in Drug-Naive Schizophrenics
Wong D, Wagner H, Tune L, Dannals R, Pearlson G, Links J, Tamminga C, Broussolle E, Ravert H, Wilson A, Toung J, Malat J, Williams J, O'Tuama L, Snyder S, Kuhar M, Gjedde A. Positron Emission Tomography Reveals Elevated D2 Dopamine Receptors in Drug-Naive Schizophrenics. Science 1986, 234: 1558-1563. PMID: 2878495, DOI: 10.1126/science.2878495.Peer-Reviewed Original ResearchConceptsD2 dopamine receptorsD2 dopamine receptor densityPositron emission tomographyGroup of patientsDopamine receptor densityDopamine receptorsCaudate nucleusReceptor densityNormal volunteersEmission tomographyDrug-naive schizophrenicsNumber of receptorsMost patientsBasal gangliaNeuroleptic drugsPostmortem studiesBiochemical abnormalitiesPatientsPsychiatric diseasesSchizophreniaReceptorsDrugsVolunteersTomographyGroup