2023
Determinants of cognitive and brain resilience to tau pathology: a longitudinal analysis
Bocancea D, Svenningsson A, van Loenhoud A, Groot C, Barkhof F, Strandberg O, Smith R, Weiner M, Aisen P, Petersen R, Aisen P, Petersen R, Jack C, Jagust W, Trojanowki J, Toga A, Beckett L, Green R, Saykin A, Morris J, Perrin R, Shaw L, Khachaturian Z, Carrillo M, Potter W, Barnes L, Bernard M, González H, Ho C, Hsiao J, Jackson J, Masliah E, Masterman D, Okonkwo O, Ryan L, Silverberg N, Fleisher A, Weiner M, Sacrey D, Fockler J, Conti C, Veitch D, Neuhaus J, Jin C, Nosheny R, Ashford M, Flenniken D, Kormo A, Green R, Montine T, Conti C, Petersen R, Aisen P, Rafii M, Raman R, Jimenez G, Donohue M, Gessert D, Salazar J, Zimmerman C, Cabrera Y, Walter S, Miller G, Coker G, Clanton T, Hergesheimer L, Smith S, Adegoke O, Mahboubi P, Moore S, Pizzola J, Shaffer E, Beckett L, Harvey D, Donohue M, Jack C, Forghanian-Arani A, Borowski B, Ward C, Schwarz C, Jones D, Gunter J, Kantarci K, Senjem M, Vemuri P, Reid R, Fox N, Malone I, Thompson P, Thomopoulos S, Nir T, Jahanshad N, DeCarli C, Knaack A, Fletcher E, Harvey D, Tosun-Turgut D, Chen S, Choe M, Crawfor K, Yushkevich P, Das S, Jagust W, Koeppe R, Reiman E, Chen K, Mathis C, Landau S, Morris J, Perrin R, Cairns N, Bernhardt H, Shaw L, Figurski M, Toga A, Crawfor K, Neu S, Saykin A, Nho K, Risacher S, Apostolova L, Shen L, Foroud T, Nudelman K, Faber K, Weiner M, Hsiao J, Silbert L, Kaye J, Dolen S, Schneider L, Pawluczyk S, Becerra M, Teodoro L, Dagerman K, Spann B, Brewer J, Vanderswag H, Ziolkowski J, Heidebrink J, Zbizek-Nulph L, Lord J, Zbizek-Nulph L, Petersen R, Mason S, Albers C, Knopman D, Johnson K, Villanueva-Meyer J, Pacini N, Lamb A, Kass J, Doody R, Chowdhury M, Dang M, Stern Y, Honig L, Mintz A, Ances B, Morris J, Winkfield D, Carroll M, Oliver A, Schneider S, Geldmacher D, Love M, Griffith R, Brockington J, Grossman H, Goldstein M, Greenberg J, Mitsis E, Shah R, Lamar M, Samuel P, Duara R, Greig-Custo M, Rodriguez R, Albert M, Onyike C, Farrington L, Rudow S, Brichko R, Kielb S, Smith A, Raj B, Fargher K, Sadowski M, Wisniewski T, Shulman M, Faustin A, Rao J, Castro K, Ulysse A, Chen S, Sheikh M, Doraiswamy P, Petrella J, James O, Borges-Neto S, Karlawish J, Wolk D, Vaishnavi S, Clark C, Arnold S, Smith C, Jicha G, El Khouli R, Raslau F, Lopez O, Oakley M, Simpson D, Porsteinsson A, Martin K, Kowalski N, Keltz M, Goldstein B, Makino K, Ismail M, Brand C, Thai G, Pierce A, Yanez B, Sosa E, Witbracht M, Kelley B, Nguyen T, Womack K, Mathews D, Levey A, Lah J, Hajjar I, Cellar J, Burns J, Swerdlow R, Brooks W, Silverman D, Kremen S, Apostolova L, Tingus K, Teng E, Graff-Radford N, Parfitt F, Poki-Walker K, Farlow M, Hake A, Matthews B, Herring S, van Dyck C, Mecca A, Good S, MacAvoy M, Carson R, Varma P, Chertkow H, Vaitekunis S, Hosein C, Black S, Stefanovic B, Heyn C, Mudge B, Sossi V, Feldman H, Assaly M, Finger E, Pasternak S, Rachinsky I, Kertesz A, Drost D, Grant I, Muse B, Rogalski E, Robso J, Mesulam M, Wu C, Johnson N, Pomara N, Hernando R, Sarrael A, Rosen H, Miller B, Perry D, Turner R, Johnson K, Reynolds B, MCCann K, Poe J, Sperling R, Johnson K, Marshall G, Yesavage J, Taylor J, Chao S, Coleman J, White J, Lane B, Belden C, Atri A, Spann B, Clar K, Killiany R, Stern R, Mez J, Kowall N, Budson A, Obisesan T, Ntekim O, Wolday S, Khan J, Nwulia E, Nadarajah S, Lerner A, Ogrocki P, Tatsuoka C, Fatica P, Fletcher E, Maillard P, Olichney J, DeCarli C, Carmichael O, Bates V, Rainka M, Borrie M, Lee C, Bartha D, Johnson S, Asthana S, Carlsson C, Perrin A, Burke A, Scharre D, Kataki M, Tarawneh R, Kelley B, Hart D, Zimmerman E, Celmins D, Miller D, Ponto L, Smith K, Koleva H, Shim H, Nam K, Schultz S, Williamson J, Craft S, Cleveland J, Yang M, Sink K, Ott B, Drake J, Tremont G, Daiello L, Drake J, Sabbagh M, Ritter A, Bernick C, Munic D, Mintz A, O'Connelll A, Mintzer J, Wiliams A, Masdeu J, Shi J, Garcia A, Sabbagh M, Newhouse P, Potkin S, Salloway S, Malloy P, Correia S, Kittur S, Pearlson G, Blank K, Anderson K, Flashman L, Seltzer M, Hynes M, Santulli R, Relkin N, Chiang G, Lee A, Lin M, Ravdin L, Weiner M, Aisen P, Weiner M, Aisen P, Petersen R, Green R, Harvey D, Jagust W, Morris J, Saykin A, Shaw L, Toga A, Trojanowki J, Neylan T, Grafman J, Green R, Montine T, Weiner M, Petersen R, Aisen P, Jimenez G, Donohue M, Gessert D, Salazar J, Zimmerman C, Walter S, Adegoke O, Mahboubi P, Danowski S, Coker G, Clanton T, Pizzola J, Shaffer E, Neylan T, Hayes J, Finley S, Harvey D, Donohue M, Bernstein M, Borowski B, Gunter J, Senjem M, Kantarci K, Ward C, Tosun-Turgut D, Chen S, Landau S, Koeppe R, Foster N, Reiman E, Chen K, Morris J, Perrin R, Franklin E, Shaw L, Trojanowki J, Korecka M, Toga A, Crawfor K, Saykin A, Foroud T, Potkin S, Shen L, Faber K, Kim S, Nho K, Wilmes K, Schneider L, Pawluczyk S, Becerra M, Teodoro L, Dagerman K, Spann B, Brewer J, Vanderswag H, Fleisher A, Stern Y, Honig L, Mintz A, Shah R, Sood A, Blanchard K, Fleischman D, Arfanakis K, Duara D, Varon D, Doraiswamy P, Petrella J, James O, Borges-Neto S, Wong T, Porsteinsson A, Goldstein B, Martin K, Thai G, Pierce A, Reist C, Yanez B, Sosa E, Witbracht M, Sadowsky C, Martinez W, Villena T, Rosen H, Perr D, Turner R, Johnson K, Reynolds B, MCCann K, Poe J, Sperling R, Johnson K, Belden C, Atri A, Spann B, Clar K, Zamrini E, Sabbagh M, Obisesan T, Ntekim O, Wolday S, Nwulia E, Nadarajah S, Johnson S, Asthana S, Carlsson C, Peskind E, Petrie E, Li G, Yesavage J, Taylor J, Chao S, Coleman J, White J, Lane B, Rosen A, Tinklenberg J, Lin M, Chiang G, Ravdin L, Relkin N, O'Connelll A, Mintzer J, Wiliams A, Mackin S, Aisen P, Raman R, Donohue M, Gessert D, Salazar J, Zimmerman C, Walter S, Adegoke O, Mahboubi P, Mackin S, Weiner M, Aisen P, Raman R, Landau S, Saykin A, Toga A, DeCarli C, Koeppe R, Green R, Drake E, Weiner M, Aisen P, Raman R, Donohue M, Mackin S, Nelson C, Bickford D, Butters M, Zmuda M, Bernstein M, Borowski B, Gunter J, Senjem M, Kantarci K, Ward C, Reyes D, Koeppe R, Landau S, Toga A, Crawfor K, Neu S, Saykin A, Foroud T, Faber K, Nho K, Nudelman K, Mackin S, Rosen H, Nelson C, Bickford D, Au Y, Scherer K, Catalinotto D, Stark S, Ong E, Fernandez D, Butters M, Zmuda M, Lopez O, Oakley M, Simpson D, La Joie R, Rosen H, Pontecorvo M, Rabinovici G, van der Flier W, Hansson O, Ossenkoppele R. Determinants of cognitive and brain resilience to tau pathology: a longitudinal analysis. Brain 2023, 146: 3719-3734. PMID: 36967222, PMCID: PMC10473572, DOI: 10.1093/brain/awad100.Peer-Reviewed Original ResearchConceptsBrain resilienceCognitive declineGreater cortical thicknessCognitive resilienceAPOE ε4 statusCortical thicknessBetter cognitive performanceCortical thinningTau-PET levelsMechanisms of resilienceLongitudinal cognitive assessmentsSlower cognitive declineBaseline cortical thicknessCognitive performanceGlobal cognitionResilience resourcesTau pathologyMild cognitive impairmentCognitive AssessmentLongitudinal study designYears of educationAlzheimer's disease spectrumCognitionCognitive impairmentBrain structuresAnatomically interpretable deep learning of brain age captures domain-specific cognitive impairment
Yin C, Imms P, Cheng M, Amgalan A, Chowdhury N, Massett R, Chaudhari N, Chen X, Thompson P, Bogdan P, Irimia A, Initiative T, Weiner M, Aisen P, Petersen R, Weiner M, Aisen P, Petersen R, Jack C, Jagust W, Trojanowki J, Toga A, Beckett L, Green R, Saykin A, Morris J, Perrin R, Shaw L, Khachaturian Z, Carrillo M, Potter W, Barnes L, Bernard M, González H, Ho C, Hsiao J, Jackson J, Masliah E, Masterman D, Okonkwo O, Perrin R, Ryan L, Silverberg N, Fleisher A, Lilly E, Weiner M, Sacrey D, Fockler J, Conti C, Veitch D, Neuhaus J, Jin C, Nosheny R, Ashford M, Flenniken D, Kormos A, Green R, Montine T, Conti C, Petersen R, Aisen P, Rafii M, Raman R, Jimenez G, Donohue M, Gessert D, Salazar J, Zimmerman C, Cabrera Y, Walter S, Miller G, Coker G, Clanton T, Hergesheimer L, Smith S, Adegoke O, Mahboubi P, Moore S, Pizzola J, Shaffer E, Sloan B, Beckett L, Harvey D, Donohue M, Jack C, Forghanian-Arani A, Borowski B, Ward C, Schwarz C, Jones D, Gunter J, Kantarci K, Senjem M, Vemuri P, Reid R, Fox N, Malone I, Thompson P, Thomopoulos S, Nir T, Jahanshad N, DeCarli C, Knaack A, Fletcher E, Harvey D, Tosun-Turgut D, Chen S, Choe M, Crawford K, Yushkevich P, Das S, Jagust W, Koeppe R, Reiman E, Chen K, Mathis C, Landau S, Morris J, Perrin R, Cairns N, Householder E, Franklin E, Bernhardt H, Taylor-Reinwald L, Shaw L, Trojanowki J, Korecka M, Figurski M, Toga A, Crawford K, Neu S, Saykin A, Nho K, Risacher S, Apostolova L, Shen L, Foroud T, Nudelman K, Faber K, Wilmes K, Weiner M, Thal L, Khachaturian Z, Hsiao J, Silbert L, Lind B, Crissey R, Kaye J, Carter R, Dolen S, Quinn J, Schneider L, Pawluczyk S, Becerra M, Teodoro L, Dagerman K, Spann B, Brewer J, Vanderswag H, Fleisher A, Ziolkowski J, Heidebrink J, Zbizek-Nulph L, Lord J, Zbizek-Nulph L, Petersen R, Mason S, Albers C, Knopman D, Johnson K, Villanueva-Meyer J, Pavlik V, Pacini N, Lamb A, Kass J, Doody R, Shibley V, Chowdhury M, Rountree S, Dang M, Stern Y, Honig L, Mintz A, Ances B, Morris J, Winkfield D, Carroll M, Stobbs-Cucchi G, Oliver A, Creech M, Mintun M, Schneider S, Geldmacher D, Love M, Griffith R, Clark D, Brockington J, Marson D, Grossman H, Goldstein M, Greenberg J, Mitsis E, Shah R, Lamar M, Samuels P, Duara R, Greig-Custo M, Rodriguez R, Albert M, Onyike C, Farrington L, Rudow S, Brichko R, Kielb S, Smith A, Raj B, Fargher K, Sadowski M, Wisniewski T, Shulman M, Faustin A, Rao J, Castro K, Ulysse A, Chen S, Sheikh M, Singleton-Garvin J, Doraiswamy P, Petrella J, James O, Wong T, Borges-Neto S, Karlawish J, Wolk D, Vaishnavi S, Clark C, Arnold S, Smith C, Jicha G, Khouli R, Raslau F, Lopez O, Oakley M, Simpson D, Porsteinsson A, Martin K, Kowalski N, Keltz M, Goldstein B, Makino K, Ismail M, Brand C, Thai G, Pierce A, Yanez B, Sosa E, Witbracht M, Kelley B, Nguyen T, Womack K, Mathews D, Quiceno M, Levey A, Lah J, Hajjar I, Cellar J, Burns J, Swerdlow R, Brooks W, Silverman D, Kremen S, Apostolova L, Tingus K, Lu P, Bartzokis G, Woo E, Teng E, Graff-Radford N, Parfitt F, Poki-Walker K, Farlow M, Hake A, Matthews B, Brosch J, Herring S, van Dyck C, Mecca A, MacAvoy M, Carson R, Varma P, Chertkow H, Vaitekunis S, Hosein C, Black S, Stefanovic B, Heyn C, Hsiung G, Kim E, Mudge B, Sossi V, Feldman H, Assaly M, Finger E, Pasternak S, Rachinsky I, Kertesz A, Drost D, Rogers J, Grant I, Muse B, Rogalski E, Robson J, Mesulam M, Kerwin D, Wu C, Johnson N, Lipowski K, Weintraub S, Bonakdarpour B, Pomara N, Hernando R, Sarrael A, Rosen H, Miller B, Perry D, Turner R, Johnson K, Reynolds B, MCCann K, Poe J, Sperling R, Johnson K, Marshall G, Yesavage J, Taylor J, Chao S, Coleman J, White J, Lane B, Rosen A, Tinklenberg J, Belden C, Spann B, Clark K, Zamrini E, Sabbagh M, Killiany R, Stern R, Mez J, Kowall N, Budson A, Obisesan T, Ntekim O, Wolday S, Khan J, Nwulia E, Nadarajah S, Lerner A, Ogrocki P, Tatsuoka C, Fatica P, Fletcher E, Maillard P, Olichney J, DeCarli C, Carmichael O, Bates V, Capote H, Rainka M, Borrie M, Lee T, Bartha R, Johnson S, Asthana S, Carlsson C, Perrin A, Burke A, Scharre D, Kataki M, Tarawneh R, Kelley B, Hart D, Zimmerman E, Celmins D, Miller D, Ponto L, Smith K, Koleva H, Shim H, Nam K, Schultz S, Williamson J, Craft S, Cleveland J, Yang M, Sink K, Ott B, Drake J, Tremont G, Daiello L, Drake J, Sabbagh M, Ritter A, Bernick C, Munic D, Mintz A, O’Connelll A, Mintzer J, Wiliams A, Masdeu J, Shi J, Garcia A, Sabbagh M, Newhouse P, Potkin S, Salloway S, Malloy P, Correia S, Kittur S, Pearlson G, Blank K, Anderson K, Flashman L, Seltzer M, Hynes M, Santulli R, Relkin N, Chiang G, Lee A, Lin M, Ravdin L, Weiner M, Aisen P, Petersen R, Weiner M, Aisen P, Petersen R, Green R, Harvey D, Jack C, Jagust W, Morris J, Saykin A, Shaw L, Toga A, Trojanowki J, Neylan T, Grafman J, Green R, Montine T, Aisen P, Jimenez G, Donohue M, Gessert D, Salazar J, Zimmerman C, Walter S, Adegoke O, Mahboubi P, Danowski S, Coker G, Clanton T, Pizzola J, Shaffer E, Nguyen-Barrera C, Neylan T, Hayes J, Finley S, Harvey D, Donohue M, Jack C, Bernstein M, Borowski B, Gunter J, Senjem M, Kantarci K, Ward C, Tosun-Turgut D, Chen S, Landau S, Koeppe R, Foster N, Reiman E, Chen K, Morris J, Perrin R, Franklin E, Shaw L, Trojanowki J, Korecka M, Figurski M, Toga A, Crawford K, Neu S, Saykin A, Foroud T, Potkin S, Shen L, Faber K, Kim S, Nho K, Wilmes K, Schneider L, Pawluczyk S, Becerra M, Teodoro L, Dagerman K, Spann B, Brewer J, Vanderswag H, Fleisher A, Stern Y, Honig L, Mintz A, Shah R, Sood A, Blanchard K, Fleischman D, Arfanakis K, Duara R, Varon D, Greig M, Doraiswamy P, Petrella J, James O, Borges-Neto S, Wong T, Porsteinsson A, Martin K, Thai G, Pierce A, Reist C, Yanez B, Sosa E, Witbracht M, Sadowsky C, Martinez W, Villena T, Rosen H, Perry D, Turner R, Johnson K, Reynolds B, MCCann K, Poe J, Sperling R, Johnson K, Marshall G, Belden C, Spann B, Clark K, Zamrini E, Sabbagh M, Obisesan T, Ntekim O, Nwulia E, Nadarajah S, Asthana S, Carlsson C, Peskind E, Petrie E, Li G, Yesavage J, Taylor J, Chao S, Coleman J, White J, Lane B, Rosen A, Tinklenberg J, Lin M, Chiang G, Ravdin L, Relkin N, O’Connelll A, Mintzer J, Wiliams A, Mackin S, Aisen P, Raman R, Jimenez-Maggiora G, Donohue M, Gessert D, Salazar J, Zimmerman C, Walter S, Adegoke O, Mahboubi P, Mackin S, Weiner M, Aisen P, Raman R, Jack C, Landau S, Saykin A, Toga A, DeCarli C, Koeppe R, Green R, Drake E, Weiner M, Aisen P, Raman R, Donohue M, Mackin S, Nelson C, Bickford D, Butters M, Zmuda M, Jack C, Bernstein M, Borowski B, Gunter J, Senjem M, Kantarci K, Ward C, Reyes D, Koeppe R, Landau S, Toga A, Crawford K, Neu S, Saykin A, Foroud T, Faber K, Nho K, Nudelman K, Mackin S, Rosen H, Nelson C, Bickford D, Au Y, Scherer K, Catalinotto D, Stark S, Ong E, Fernandez D, Butters M, Zmuda M, Lopez O, Oakley M, Simpson D. Anatomically interpretable deep learning of brain age captures domain-specific cognitive impairment. Proceedings Of The National Academy Of Sciences Of The United States Of America 2023, 120: e2214634120. PMID: 36595679, PMCID: PMC9926270, DOI: 10.1073/pnas.2214634120.Peer-Reviewed Original ResearchConceptsChronological ageDomain-specific cognitive impairmentConvolutional neural networkCognitive impairmentBrain age estimatesExecutive functionNeurocognitive measuresNeurocognitive trajectoriesMild cognitive impairmentBrain ageNormal participantsCognitive declineCN individualsSymptom severityMagnetic resonance imagesCN participantsNeuroanatomic changesDeep learning modelsIndependent samplesBrain agingIndividual patternsParticipantsLearning modelImpairmentIndividuals
2019
Blood-based protein mediators of senility with replications across biofluids and cohorts
Royall D, Palmer R, Weiner M, Aisen P, Weiner M, Petersen R, Jack C, Jagust W, Trojanowki J, Toga A, Beckett L, Green R, Saykin A, Morris J, Shaw L, Khachaturian Z, Sorensen G, Carrillo M, Kuller L, Raichle M, Paul S, Davies P, Fillit H, Hefti F, Holtzman D, Mesulam M, Potter W, Snyder P, Montine T, Jimenez G, Donohue M, Gessert D, Harless K, Salazar J, Cabrera Y, Walter S, Hergesheimer L, Harvey D, Lee V, Korecka M, Figurski M, Thal L, Thal L, Buckholtz N, Snyder P, Albert M, Frank R, Quinn J, Silbert L, Lind B, Kaye J, Carter R, Dolen S, Schneider L, Pawluczyk S, Becerra M, Teodoro L, Spann B, Brewer J, Vanderswag H, Fleisher A, Ziolkowski J, Heidebrink J, Lord J, Mason S, Albers C, Knopman D, Johnson K, Villanueva-Meyer J, Pavlik V, Pacini N, Lamb A, Kass J, Doody R, Shibley V, Chowdhury M, Rountree S, Dang M, Stern Y, Honig L, Bell K, Yeh R, Ances B, Morris J, Winkfield D, Carroll M, Oliver A, Creech M, Mintun M, Schneider S, Marson D, Geldmacher D, Love M, Griffith R, Clark D, Brockington J, Grossman H, Mitsis E, Shah R, Lamar M, Samuels P, Duara R, Greig-Custo M, Rodriguez R, Onyike C, D’Agostino D, Sheikh S, Singleton-Garvin J, Ulysse A, Gaikwad M, Doraiswamy P, Petrella J, James O, Borges-Neto S, Wong T, Coleman E, Karlawish J, Wolk D, Vaishnavi S, Clark C, Arnold S, Smith C, Jicha G, Hardy P, Khouli R, Oates E, Conrad G, Lopez O, Oakley M, Simpson D, Porsteinsson A, Martin K, Kowalksi N, Keltz M, Goldstein B, Makino K, Ismail M, Brand C, Thai G, Pierce A, Yanez B, Sosa E, Witbracht M, Womack K, Mathews D, Quiceno M, Levey A, Lah J, Cellar J, Burns J, Swerdlow R, Brooks W, Woo E, Silverman D, Teng E, Kremen S, Apostolova L, Tingus K, Lu P, Bartzokis G, Graff-Radford N, Parfitt F, Poki-Walker K, Farlow M, Hake A, Matthews B, Brosch J, Herring S, van Dyck C, Carson R, Varma P, Chertkow H, Bergman H, Hosein C, Kielb M, Black S, Stefanovic B, Heyn C, Hsiung G, Mudge B, Sossi V, Feldman H, Assaly M, Finger E, Pasternack S, Pavlosky W, Rachinsky I, Drost D, Kertesz A, Bernick C, Munic D, Mesulam M, Rogalski E, Lipowski K, Weintraub S, Bonakdarpour B, Kerwin D, Wu C, Johnson N, Sadowsky C, Villena T, Turner R, Johnson K, Reynolds B, Sperling R, Johnson K, Marshall G, Yesavage J, Taylor J, Chao S, Lane B, Rosen A, Tinklenberg J, Zamrini E, Belden C, Sirrel S, Kowall N, Killiany R, Budson A, Norbash A, Johnson P, Obisesan T, Oyonumo N, Allard J, Ogunlana O, Lerner A, Ogrocki P, Tatsuoka C, Fatica P, Fletcher E, Maillard P, Olichney J, DeCarli C, Carmichael O, Kittur S, Borrie M, Lee T, Bartha R, Johnson S, Asthana S, Carlsson C, Tariot P, Burke A, Hetelle J, DeMarco K, Trncic N, Reeder S, Bates V, Capote H, Rainka M, Scharre D, Kataki M, Tarawneh R, Zimmerman E, Celmins D, Hart D, Pearlson G, Blank K, Anderson K, Flashman L, Seltzer M, Hynes M, Santulli R, Sink K, Yang M, Mintz A, Ott B, Tremont G, Daiello L, Salloway S, Malloy P, Correia S, Lee A, Rosen H, Miller B, Perry D, Mintzer J, Spicer K, Bachman D, Pasternak S, Rogers J, Pomara N, Hernando R, Sarrael A, Miller D, Smith K, Koleva H, Nam K, Shim H, Schultz S, Relkin N, Chiang G, Lin M, Ravdin L, Smith A, Leach C, Raj B, Fargher K, Bodge C. Blood-based protein mediators of senility with replications across biofluids and cohorts. Brain Communications 2019, 2: fcz036. PMID: 32954311, PMCID: PMC7425523, DOI: 10.1093/braincomms/fcz036.Peer-Reviewed Original ResearchDementia severityTexas Alzheimer's ResearchCare ConsortiumDisease Neuroimaging InitiativeAlzheimer's ResearchBlood-based protein biomarkersBody mass indexFollicle-stimulating hormoneLow-density lipoproteinAlzheimer's Disease Neuroimaging InitiativeLatent dementia phenotypeMass indexAge-specific effectsAge effectsDementia phenotypePancreatic polypeptideCognitive frailtyDisease processCognitive declineSeverityProtein mediatorsBiomarkersUnique effectsMediatorsCognitive performance measuresType 2 diabetes mellitus, brain atrophy, and cognitive decline.
Moran C, Beare R, Wang W, Callisaya M, Srikanth V, Weiner M, Aisen P, Weiner M, Aisen P, Petersen R, Jack C, Jagust W, Trojanowki J, Toga A, Beckett L, Green R, Saykin A, Morris J, Liu E, Green R, Montine T, Petersen R, Aisen P, Gamst A, Thomas R, Donohue M, Walter S, Gessert D, Sather T, Beckett L, Harvey D, Gamst A, Donohue M, Kornak J, Jack C, Dale A, Bernstein M, Felmlee J, Fox N, Thompson P, Schuff N, Alexander G, DeCarli C, Jagust W, Bandy D, Koeppe R, Foster N, Reiman E, Chen K, Mathis C, Morris J, Cairns N, Taylor-Reinwald L, Trojanowki J, Shaw L, Lee V, Korecka M, Toga A, Crawford K, Neu S, Saykin A, Foroud T, Potkin S, Shen L, Kachaturian Z, Frank R, Snyder P, Molchan S, Kaye J, Quinn J, Lind B, Dolen S, Schneider L, Pawluczyk S, Spann B, Brewer J, Vanderswag H, Heidebrink J, Lord J, Petersen R, Johnson K, Doody R, Villanueva-Meyer J, Chowdhury M, Stern Y, Honig L, Bell K, Morris J, Ances B, Carroll M, Leon S, Mintun M, Schneider S, Marson D, Griffith R, Clark D, Grossman H, Mitsis E, Romirowsky A, deToledo-Morrell L, Shah R, Duara R, Varon D, Roberts P, Albert M, Onyike C, Kielb S, Rusinek H, de Leon M, Glodzik L, De Santi S, Doraiswamy P, Petrella J, Coleman R, Arnold S, Karlawish J, Wolk D, Smith C, Jicha G, Hardy P, Lopez O, Oakley M, Simpson D, Porsteinsson A, Goldstein B, Martin K, Makino K, Ismail M, Brand C, Mulnard R, Thai G, McAdams-Ortiz C, Womack K, Mathews D, Quiceno M, Diaz-Arrastia R, King R, Weiner M, Martin-Cook K, DeVous M, Levey A, Lah J, Cellar J, Burns J, Anderson H, Swerdlow R, Apostolova L, Lu P, Bartzokis G, Silverman D, Graff-Radford N, Parfitt F, Johnson H, Farlow M, Hake A, Matthews B, Herring S, van Dyck C, Carson R, MacAvoy M, Chertkow H, Bergman H, Hosein C, Black S, Stefanovic B, Caldwell C, Robin Hsiung G, Feldman H, Mudge B, Assaly M, Kertesz A, Rogers J, Trost D, Bernick C, Munic D, Kerwin D, Mesulam M, Lipowski K, Wu C, Johnson N, Sadowsky C, Martinez W, Villena T, Turner R, Johnson K, Reynolds B, Sperling R, Johnson K, Marshall G, Frey M, Yesavage J, Taylor J, Lane B, Rosen A, Tinklenberg J, Sabbagh M, Belden C, Jacobson S, Kowall N, Killiany R, Budson A, Norbash A, Johnson P, Obisesan T, Wolday S, Bwayo S, Lerner A, Hudson L, Ogrocki P, Fletcher E, Carmichael O, Olichney J, DeCarli C, Kittur S, Borrie M, Lee T, Bartha D, Johnson S, Asthana S, Carlsson C, Potkin S, Preda A, Nguyen D, Tariot P, Fleisher A, Reeder S, Bates V, Capote H, Rainka M, Scharre D, Kataki M, Zimmerman E, Celmins D, Brown A, Pearlson G, Blank K, Anderson K, Saykin A, Santulli R, Schwartz E, Sink K, Williamson J, Garg P, Watkins F, Ott B, Querfurth H, Tremont G, Salloway S, Malloy P, Correia S, Rosen H, Miller B, Mintzer J, Longmire C, Spicer K, Finger E, Rachinsky I, Rogers J, Kertesz A, Drost D, Pomara N, Hernando R, Sarrael A, Schultz S, Boles Ponto L, Shim H, Smith K, Relkin N, Chaing G, Raudin L, Smith A, Fargher K, Raj B. Type 2 diabetes mellitus, brain atrophy, and cognitive decline. Neurology 2019, 92: e823-e830. PMID: 30674592, PMCID: PMC7987953, DOI: 10.1212/wnl.0000000000006955.Peer-Reviewed Original ResearchConceptsBaseline cortical thicknessType 2 diabetes mellitusCortical thicknessCognitive declineAlzheimer's diseaseCognitive functionDiabetes mellitusCerebrovascular disease burdenGlucose-lowering agentsPresence of T2DMLower cortical thicknessLongitudinal relationshipAlzheimer's Disease Neuroimaging Initiative (ADNI) cohortMild cognitive impairmentStudy entryBrain atrophyBlood glucoseDisease burdenInitiative cohortT2DMBrain MRICognitive impairmentNormal cognitionRelevant covariatesOlder people
2016
Accelerating rates of cognitive decline and imaging markers associated with &bgr;-amyloid pathology
Insel P, Mattsson N, Mackin R, Schöll M, Nosheny R, Tosun D, Donohue M, Aisen P, Jagust W, Weiner M, Weiner M, Aisen P, Weiner M, Aisen P, Petersen R, Jack C, Jagust W, Trojanowki J, Toga A, Beckett L, Green R, Saykin A, Morris J, Liu E, Green R, Montine T, Petersen R, Aisen P, Gamst A, Thomas R, Donohue M, Walter S, Gessert D, Sather T, Beckett L, Harvey D, Gamst A, Donohue M, Kornak J, Jack C, Dale A, Bernstein M, Felmlee J, Fox N, Thompson P, Schuff N, Alexander G, DeCarli C, Jagust W, Bandy D, Koeppe R, Foster N, Reiman E, Chen K, Mathis C, Morris J, Cairns N, Taylor-Reinwald L, Trojanowki J, Shaw L, Lee V, Korecka M, Toga A, Crawford K, Neu S, Saykin A, Foroud T, Potkin S, Shen L, Kachaturian Z, Frank R, Snyder P, Molchan S, Kaye J, Quinn J, Lind B, Dolen S, Schneider L, Pawluczyk S, Spann B, Brewer J, Vanderswag H, Heidebrink J, Lord J, Petersen R, Johnson K, Doody R, Villanueva-Meyer J, Chowdhury M, Stern Y, Honig L, Bell K, Morris J, Ances B, Carroll M, Leon S, Mintun M, Schneider S, Marson D, Griffith R, Clark D, Grossman H, Mitsis E, Romirowsky A, deToledo-Morrell L, Shah R, Duara R, Varon D, Roberts, CNA P, Albert M, Onyike C, Kielb S, Rusinek H, de Leon M, Glodzik L, De Santi S, Doraiswamy P, Petrella J, Coleman R, Arnold S, Karlawish J, Wolk D, Smith C, Jicha G, Hardy P, Lopez O, Oakley M, Simpson D, Porsteinsson A, Goldstein B, Martin K, Makino K, Ismail M, Brand C, Mulnard R, Thai G, Mc-Adams-Ortiz C, Womack K, Mathews D, Quiceno M, Diaz-Arrastia R, King R, Weiner M, Martin-Cook K, DeVous M, Levey A, Lah J, Cellar J, Burns J, Anderson H, Swerdlow R, Apostolova L, Lu P, Bartzokis G, Silverman D, Graff-Radford, MBBCH N, Parfitt F, Johnson H, Farlow M, Hake A, Matthews B, Herring S, van Dyck C, Carson R, MacAvoy M, Chertkow H, Bergman H, Hosein C, Black S, Stefanovic B, Caldwell C, Robin Hsiung G, Feldman H, Mudge B, Assaly M, Kertesz A, Rogers J, Trost D, Bernick C, Munic D, Kerwin D, Mesulam M, Lipowski K, Wu C, Johnson N, Sadowsky C, Martinez W, Villena T, Turner R, Johnson K, Reynolds B, Sperling R, Johnson K, Marshall G, Frey M, Yesavage J, Taylor J, Lane B, Rosen A, Tinklenberg J, Sabbagh M, Belden C, Jacobson S, Kowall N, Killiany R, Budson A, Norbash A, Johnson P, Obisesan T, Wolday S, Bwayo S, Lerner A, Hudson L, Ogrocki P, Fletcher E, Carmichael O, Olichney J, DeCarli C, Kittur S, Borrie M, Lee T, Bartha R, Johnson S, Asthana S, Carlsson C, Potkin S, Preda A, Nguyen D, Tariot P, Fleisher A, Reeder S, Bates V, Capote H, Rainka M, Scharre D, Kataki M, Zimmerman E, Celmins D, Brown A, Pearlson G, Blank K, Anderson K, Saykin A, Santulli R, Schwartz E, Sink K, Williamson J, Garg P, Watkins F, Ott B, Querfurth H, Tremont G, Salloway S, Malloy P, Correia S, Rosen H, Miller B, Mintzer J, Longmire C, Spicer K, Finger E, Rachinsky I, Rogers J, Kertesz A, Drost D, Pomara N, Hernando R, Sarrael A, Schultz S, Boles Ponto L, Shim H, Elizabeth Smith K, Relkin N, Chaing G, Raudin L, Smith A, Fargher K, Ashok Raj B. Accelerating rates of cognitive decline and imaging markers associated with &bgr;-amyloid pathology. Neurology 2016, 86: 1887-1896. PMID: 27164667, PMCID: PMC4873684, DOI: 10.1212/wnl.0000000000002683.Peer-Reviewed Original ResearchMeSH KeywordsAgedAmyloid beta-PeptidesAniline CompoundsAtrophyBiomarkersBrainCognitionCognitive DysfunctionDisease ProgressionEthylene GlycolsFemaleFluorodeoxyglucose F18HumansLongitudinal StudiesMagnetic Resonance ImagingMaleMental Status ScheduleNeuropsychological TestsPeptide FragmentsPositron-Emission TomographyRadiopharmaceuticalsRegression AnalysisConceptsMild cognitive impairmentFunctional declineNeuronal injuryCSF Aβ42Florbetapir PETAmyloid positivityRate of declineCognitive declineTemporal lobe atrophy ratesΒ-amyloid pathologyEarly Alzheimer's diseaseFluorodeoxyglucose PETAmyloid pathologyFDG-PETFuture trialsAtrophy ratesInclusion criteriaMixed-effects regressionΒ-amyloidCognitive impairmentAlzheimer's diseaseFirst signPatientsInjuryConsiderable proportion
2012
Response to Letters Regarding Article, “Average Daily Blood Pressure, Not Office Blood Pressure, Is Associated With Progression of Cerebrovascular Disease and Cognitive Decline in Older People”
White W, Campbell P, Wolfson L, Wakefield D, Schmidt J, Hall C, Moscufo N, Guttmann C, Kaplan R, Pearlson G. Response to Letters Regarding Article, “Average Daily Blood Pressure, Not Office Blood Pressure, Is Associated With Progression of Cerebrovascular Disease and Cognitive Decline in Older People”. Circulation 2012, 125: e1018. DOI: 10.1161/circulationaha.112.098509.Peer-Reviewed Original Research
1996
CT measurement of suprasellar cistern predicts rate of cognitive decline in Alzheimer's disease
Aylward E, Rasmusson D, Brandt J, Raimundo L, Folstein M, Pearlson G. CT measurement of suprasellar cistern predicts rate of cognitive decline in Alzheimer's disease. Journal Of The International Neuropsychological Society 1996, 2: 89-95. PMID: 9375193, DOI: 10.1017/s135561770000093x.Peer-Reviewed Original ResearchConceptsSuprasellar cisternAlzheimer's diseaseAD patientsCT measuresQuantitative computed tomography (CT) measuresMini-Mental State Exam scoreCT measurementsComputed tomography measuresProbable Alzheimer's diseaseState Exam scoreBicaudate ratioBifrontal ratioNeurocognitive declineLateral ventricleThird ventricleCT scanTomography measuresCognitive declineCognitive functionPatientsAdaptive functioningDiseaseScansNeuropsychological measuresCognitive functioning
1991
Suprasellar cistern measures as a reflection of dementia in Alzheimer's disease but not Huntington's disease
Aylward E, Karagiozis H, Pearlson G, Folstein M. Suprasellar cistern measures as a reflection of dementia in Alzheimer's disease but not Huntington's disease. Journal Of Psychiatric Research 1991, 25: 31-47. PMID: 1827501, DOI: 10.1016/0022-3956(91)90014-2.Peer-Reviewed Original ResearchConceptsAlzheimer's diseaseSuprasellar cisternDisease patientsAD patientsTemporal lobeCognitive statusHuntington's diseaseRespective age-matched controlsBasal forebrain areasAge-matched controlsHuntington's disease patientsForebrain areasEntorhinal cortexCognitive declinePatientsDiseaseBrain widthLobeHDStatusAtrophyDementiaPerceptual ratingsCortex
1988
Manic Syndrome Associated With Zidovudine
Schaerf F, Miller R, Pearlson G, Kaminsky M, Weaver D. Manic Syndrome Associated With Zidovudine. JAMA 1988, 260: 3587-3588. DOI: 10.1001/jama.1988.03410240045016.Peer-Reviewed Original ResearchCases of maniaZidovudine therapySyndrome AssociatedHuman immunodeficiency virus-seropositive individualsAffective disordersImmunodeficiency syndrome dementia complexZidovudine dosageZidovudine treatmentSuch patientsDementia complexManic episodesMajor depressionFamily historyDepressive symptomsCognitive declinePsychiatric syndromesPatientsPersonal historyZidovudineTherapyEt al1ManiaDisordersAssociatedSyndrome