2019
Impact of early antiretroviral treatment on sexual behaviour: a randomised comparison
Lampe FC, Rodger AJ, Burman W, Grulich A, Friedland G, Sadr WE, Neaton J, Corbelli GM, Emery S, Molina JM, Orkin C, Gatell J, Gerstoft J, Ruxrungtham K, de Souza M, Phillips AN. Impact of early antiretroviral treatment on sexual behaviour: a randomised comparison. AIDS 2019, 33: 2337-2350. PMID: 31764099, PMCID: PMC6882545, DOI: 10.1097/qad.0000000000002359.Peer-Reviewed Original ResearchConceptsEarly antiretroviral treatmentHIV-serodifferent partnersAntiretroviral treatmentMonth 12Month 24CD4 cell countHIV-positive adultsSexual behaviorHIV infectiousnessImmediate armViral suppressionPrimary outcomeHigh prevalenceCondomless sexCell countMSMCells/Lower absolute levelsSexHeterosexual menTreatmentHeterosexualsArmAbsolute levelsPrevalence
2005
Population Pharmacokinetics of Delavirdine and N-Delavirdine in HIV-Infected Individuals
Smith PF, DiCenzo R, Forrest A, Shelton M, Friedland G, Para M, Pollard R, Fischi M, DiFrancesco R, Morse GD. Population Pharmacokinetics of Delavirdine and N-Delavirdine in HIV-Infected Individuals. Clinical Pharmacokinetics 2005, 44: 99-109. PMID: 15634033, DOI: 10.2165/00003088-200544010-00004.Peer-Reviewed Original ResearchConceptsLarge interpatient variabilityPharmacokinetic parameter estimatesCombination regimensPopulation pharmacokineticsInterpatient variabilityNon-nucleoside reverse transcriptase inhibitorPopulation pharmacokinetic parameter estimatesCells/mm3Double-blind studyHIV-1 infectionMean apparent volumeAge 37 yearsPopulation pharmacokinetic analysisReverse transcriptase inhibitorVolume of distributionFirst-order clearanceTherapeutic drug monitoringTarget drug concentrationsCD4 countMonotherapy studiesOral clearanceDosage regimensPlasma concentrationsTranscriptase inhibitorPharmacokinetic analysis
1981
Infective endocarditis: an analysis based on strict case definitions.
Von Reyn C, Levy B, Arbeit R, Friedland G, Crumpacker C. Infective endocarditis: an analysis based on strict case definitions. Annals Of Internal Medicine 1981, 94: 505-18. PMID: 7011141, DOI: 10.7326/0003-4819-94-4-505.Peer-Reviewed Original ResearchConceptsStrict case definitionValvular diseaseCase definitionAdvanced mean ageShorter mean durationNosocomial endocarditisProsthesis endocarditisNeurologic eventsPossible endocarditisCardiac surgeryHeart failureInfective endocarditisMean ageMean durationEarly recognitionClinical studiesEndocarditisHigh incidenceInvasive proceduresViridans streptococciLarge seriesSuspect casesStaphylococcus aureusMortalityDisease