2022
Bedaquiline Adherence Measured by Electronic Dose Monitoring Predicts Clinical Outcomes in the Treatment of Patients With Multidrug-Resistant Tuberculosis and HIV/AIDS
O'Donnell MR, Padayatchi N, Wolf A, Zelnick J, Daftary A, Orrell C, Nimmo C, Baldwin M, Boodhram R, Maharaj B, Amico KR, Naidoo K, Friedland G. Bedaquiline Adherence Measured by Electronic Dose Monitoring Predicts Clinical Outcomes in the Treatment of Patients With Multidrug-Resistant Tuberculosis and HIV/AIDS. JAIDS Journal Of Acquired Immune Deficiency Syndromes 2022, 90: 325-332. PMID: 35195572, PMCID: PMC11077859, DOI: 10.1097/qai.0000000000002940.Peer-Reviewed Original ResearchConceptsMDR-TB treatment outcomesResistance-associated variantsTreatment outcomesAntiretroviral therapyMDR-TBART adherenceMultidrug-resistant tuberculosis treatmentHIV treatment outcomesProspective cohort studyMultidrug-resistant tuberculosisEnd of treatmentTreatment of patientsSuccessful treatment outcomeElectronic dose monitoring devicesHIV/AIDSCohort studyClinical outcomesMultivariable analysisNovel regimensMedication adherenceAdherence thresholdTuberculosis treatmentTreatment completionLow adherenceDose monitoring
2007
Antiretroviral Treatment Regimen Outcomes Among HIV-Infected Prisoners
Springer SA, Friedland GH, Doros G, Pesanti E, Altice FL. Antiretroviral Treatment Regimen Outcomes Among HIV-Infected Prisoners. HIV Research & Clinical Practice 2007, 8: 205-212. PMID: 17720660, PMCID: PMC2409059, DOI: 10.1310/hct0804-205.Peer-Reviewed Original ResearchConceptsAntiretroviral therapyImmunological outcomesHIV-1 RNA levelsCells/mulActive antiretroviral therapyEffective antiretroviral therapyRetrospective cohort studyDuration of therapyKaplan-Meier curvesHIV-1 RNAProportion of subjectsHAART strategyTriple NRTICohort studyCopies/Incarceration periodsTreatment strategiesHigh prevalenceMean changeStudy groupNRTIsHIVTherapyRNA levelsLaboratory data
1993
Effects of HIV infection on the serologic manifestations and response to treatment of syphilis in intravenous drug users.
Gourevitch M, Selwyn P, Davenny K, Buono D, Schoenbaum E, Klein R, Friedland G. Effects of HIV infection on the serologic manifestations and response to treatment of syphilis in intravenous drug users. Annals Of Internal Medicine 1993, 118: 350-5. PMID: 8094280, DOI: 10.7326/0003-4819-118-5-199303010-00005.Peer-Reviewed Original ResearchConceptsIntravenous drug usersTreatment of syphilisStages of syphilisSerologic manifestationsDrug usersNontreponemal titersHIV infectionHuman immunodeficiency virus (HIV) infectionMethadone maintenance treatment programHIV serologic statusHIV-seronegative patientsHIV-seropositive patientsImmunodeficiency virus infectionHIV seropositive casesMaintenance treatment programFulminant manifestationCD4 countCohort studyHIV-seropositiveClinical courseStandard dosesEarly syphilisClinical manifestationsSerologic statusSerologic tests