2020
Dependence of fluorodeoxyglucose (FDG) uptake on cell cycle and dry mass: a single-cell study using a multi-modal radiography platform
Sung Y, Tetrault M, Takahashi K, Ouyang J, Pratx G, Fakhri G, Normandin M. Dependence of fluorodeoxyglucose (FDG) uptake on cell cycle and dry mass: a single-cell study using a multi-modal radiography platform. Scientific Reports 2020, 10: 4280. PMID: 32152343, PMCID: PMC7062696, DOI: 10.1038/s41598-020-59515-0.Peer-Reviewed Original ResearchMeSH KeywordsCell CycleCell DivisionCell ProliferationFluorodeoxyglucose F18HeLa CellsHumansPositron-Emission TomographyRadiopharmaceuticalsSingle-Cell AnalysisConceptsCell divisionHeLa cellsDry massM phaseCell dry massCancer compared to normal tissuesCell cycle phasesHouse-keeping proteinsSingle-cell studiesSingle-cell levelIncreased dry massProliferation indexCell cycleG1 phaseProportion of cellsHigher glucose uptakeFluorodeoxyglucose uptakeGlucose uptakeHeLaUptake rate
2019
Lysosome‐Targeted Bioprobes for Sequential Cell Tracking from Macroscopic to Microscopic Scales
Park G, Lee J, Levitz A, Fakhri G, Hwang N, Henary M, Choi H. Lysosome‐Targeted Bioprobes for Sequential Cell Tracking from Macroscopic to Microscopic Scales. Advanced Materials 2019, 31: e1806216. PMID: 30740778, PMCID: PMC6574216, DOI: 10.1002/adma.201806216.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsCell TrackingHumansLysosomesMiceMice, Inbred C57BLMolecular ProbesPC-3 CellsSingle-Cell AnalysisConceptsMechanism of actionEfficient cellular labellingLive cell trackingCytoplasmic membraneCell trackingOptical propertiesLiving cellsNear-infraredCell-based therapeuticsHost tissuesTrackingCellular analysisLipophilic cationsChemical treatmentCellular effluxLiving organismsTarget cellsCellsCellular retentionExcellent cell permeationTarget tissues