2019
Endothelial TGF-β signalling drives vascular inflammation and atherosclerosis
Chen PY, Qin L, Li G, Wang Z, Dahlman JE, Malagon-Lopez J, Gujja S, Cilfone N, Kauffman K, Sun L, Sun H, Zhang X, Aryal B, Canfran-Duque A, Liu R, Kusters P, Sehgal A, Jiao Y, Anderson D, Gulcher J, Fernandez-Hernando C, Lutgens E, Schwartz M, Pober J, Chittenden T, Tellides G, Simons M. Endothelial TGF-β signalling drives vascular inflammation and atherosclerosis. Nature Metabolism 2019, 1: 912-926. PMID: 31572976, PMCID: PMC6767930, DOI: 10.1038/s42255-019-0102-3.Peer-Reviewed Original ResearchConceptsTGF-β signalingVascular inflammationDisease progressionPlaque growthProgressive vascular diseaseVessel wall inflammationChronic inflammatory responseSpecific therapeutic interventionsAtherosclerotic plaque growthHyperlipidemic micePlaque inflammationWall inflammationProinflammatory effectsVascular diseaseInflammatory responseVascular permeabilityAtherosclerotic plaquesAbnormal shear stressTherapeutic interventionsInflammationEndothelial TGFΒ signalingVessel wallAtherosclerosisLipid retention
2018
Central artery stiffness and thoracic aortopathy
Humphrey J, Tellides G. Central artery stiffness and thoracic aortopathy. AJP Heart And Circulatory Physiology 2018, 316: h169-h182. PMID: 30412443, PMCID: PMC6880196, DOI: 10.1152/ajpheart.00205.2018.Peer-Reviewed Original ResearchConceptsCentral arteriesEnd-organ diseaseProximal thoracic aortaCentral artery stiffnessPrimary risk factorUncontrolled hypertensionAntihypertensive medicationsNonsurgical treatmentSignificant morbidityArtery stiffnessAortic aneurysmPulse pressureRisk factorsThoracic aortaDisease progressionStrenuous exerciseMouse modelMarfan syndromeWeight liftingGlobal hemodynamicsDysfunctional mechanosensingLethal conditionAortaGenetic mutationsArteryChapter 7 Vascular mechanobiology, immunobiology, and arterial growth and remodeling
Caulk A, Tellides G, Humphrey J. Chapter 7 Vascular mechanobiology, immunobiology, and arterial growth and remodeling. 2018, 215-248. DOI: 10.1016/b978-0-12-812952-4.00007-6.Peer-Reviewed Original Research