2001
CD4+ T-Cell Effectors Inhibit Epstein-Barr Virus-Induced B-Cell Proliferation
Nikiforow S, Bottomly K, Miller G. CD4+ T-Cell Effectors Inhibit Epstein-Barr Virus-Induced B-Cell Proliferation. Journal Of Virology 2001, 75: 3740-3752. PMID: 11264363, PMCID: PMC114865, DOI: 10.1128/jvi.75.8.3740-3752.2001.Peer-Reviewed Original ResearchMeSH KeywordsAdultB-LymphocytesCD4-Positive T-LymphocytesCD8-Positive T-LymphocytesCell DivisionCell SizeCells, CulturedEpstein-Barr Virus InfectionsEpstein-Barr Virus Nuclear AntigensFlow CytometryHerpesvirus 4, HumanHumansImmunologic MemoryLymphocyte CountReceptors, IgESerologyTacrolimusT-Lymphocyte SubsetsConceptsEpstein-Barr virusB cell proliferationT cellsB cellsB-cell lymphoproliferative diseaseRemoval of CD4Effector T cellsMemory T cellsT cell effectorsT cell surveillanceCytolytic T cellsEarly proliferative phaseCell linesImmune controlLymphoproliferative diseaseImmunodeficient hostsImmune surveillanceLymphoblastoid cell linesCD4Proliferative phaseImmortalized cell linesCD8CD23VirusInfection
1999
Amino Acid Substitutions Reveal Distinct Functions of Serine 186 of the ZEBRA Protein in Activation of Early Lytic Cycle Genes and Synergy with the Epstein-Barr Virus R Transactivator
Francis A, Ragoczy T, Gradoville L, Heston L, El-Guindy A, Endo Y, Miller G. Amino Acid Substitutions Reveal Distinct Functions of Serine 186 of the ZEBRA Protein in Activation of Early Lytic Cycle Genes and Synergy with the Epstein-Barr Virus R Transactivator. Journal Of Virology 1999, 73: 4543-4551. PMID: 10233912, PMCID: PMC112494, DOI: 10.1128/jvi.73.6.4543-4551.1999.Peer-Reviewed Original ResearchConceptsLytic cycle genesLatent virusZEBRA proteinOverexpression of RtaEpstein-Barr virusLatent EBV genomeBRLF1 expressionEarly lytic cycle genesAmino acid substitutionsEBV genomeBRLF1BRLF1 promoterCycle genesAcid substitutionsVirusEpstein-Barr virus R transactivatorSerine 186Distinct phenotypesLytic life cycleR transactivatorActivationDifferent amino acid substitutionsResponse elementS186Expression
1998
A viral gene that activates lytic cycle expression of Kaposi’s sarcoma-associated herpesvirus
Sun R, Lin S, Gradoville L, Yuan Y, Zhu F, Miller G. A viral gene that activates lytic cycle expression of Kaposi’s sarcoma-associated herpesvirus. Proceedings Of The National Academy Of Sciences Of The United States Of America 1998, 95: 10866-10871. PMID: 9724796, PMCID: PMC27987, DOI: 10.1073/pnas.95.18.10866.Peer-Reviewed Original ResearchMeSH KeywordsAmino Acid SequenceBase SequenceCloning, MolecularDNA PrimersDNA, ComplementaryGene Expression Regulation, NeoplasticGenes, ViralHerpesvirus 4, HumanHerpesvirus 8, HumanHumansMolecular Sequence DataSarcoma, KaposiSequence Homology, Amino AcidTranscription, GeneticTumor Cells, CulturedVirus ActivationConceptsEpstein-Barr virusKaposi's sarcoma-associated herpesvirusSarcoma-associated herpesvirusSmall viral capsid antigenPathogenesis of KSHVLytic cycle gene expressionViral capsid antigenLatent viral genomeCapsid antigenLytic cycle genesInterleukin-6Immediate early genesViral cytokineEarly lytic genesLytic genesHerpesvirusVirusViral genesViral genomeExpressionGene expressionCytokinesPathogenesisCycle genesGenes
1995
Transmissible Retrovirus in Epstein-Burr Virus-Producer B95-8 Cells
Sun R, Grogan E, Shedd D, Bykovsky A, Kushnaryov V, Grossberg S, Miller G. Transmissible Retrovirus in Epstein-Burr Virus-Producer B95-8 Cells. Virology 1995, 209: 374-383. PMID: 7778272, DOI: 10.1006/viro.1995.1269.Peer-Reviewed Original ResearchMeSH KeywordsAmino Acid SequenceAnimalsBase SequenceBetaretrovirusB-LymphocytesCallithrixCell LineCloning, MolecularDNA PrimersDNA, ComplementaryGene LibraryGene Products, gagGenes, gagHerpesvirus 4, HumanHumansMicroscopy, ElectronMolecular Sequence DataPolymerase Chain ReactionRepetitive Sequences, Nucleic AcidSaimiriT-LymphocytesVirus ReplicationConceptsEpstein-Barr virusB95-8 cellsAbsence of EBVCell linesB95-8 isolateB95-8 strainMarmoset cell linesHuman lymphoid cell linesT cell linesLymphoid cell linesType D retrovirusHuman BLymphocyte immortalizationInfectious virusViral replicationHuman isolatesGag regionBiologic propertiesTransmissible retrovirusUltrastructural appearanceD retrovirusesAmino acid changesVirusSMRVGag sequences
1992
Detection of Epstein‐Barr virus in the brain by the polymerase chain reaction
Pedneault L, Katz B, Miller G. Detection of Epstein‐Barr virus in the brain by the polymerase chain reaction. Annals Of Neurology 1992, 32: 184-192. PMID: 1324632, DOI: 10.1002/ana.410320210.Peer-Reviewed Original ResearchConceptsEpstein-Barr virusEBV DNAPolymerase chain reactionRole of EBVChain reactionCentral nervous system syndromeDiverse neurological syndromesKidney transplant recipientsHerpes group virusesTransplant recipientsMetabolic encephalopathiesBrain biopsyImmunodeficiency syndromeNeurological syndromeImmunodeficient hostsEBV genomeBrain specimensViral isolationPatientsGroup virusesSerological testsSyndromeBrainVirusEncephalitis
1991
Relation between HIV-1 syncytium inhibition antibodies and clinical outcome in children
Brenner TJ, Dahl KE, Miller G, Andiman W, Andiman WA, Olson B, Miller G, Andiman W, Miller G. Relation between HIV-1 syncytium inhibition antibodies and clinical outcome in children. The Lancet 1991, 337: 1001-1005. PMID: 1673167, DOI: 10.1016/0140-6736(91)92660-t.Peer-Reviewed Original ResearchConceptsLymphocytic interstitial pneumonitisOpportunistic infectionsClinical outcomesSyncytium formationCD4 receptorHIV-1-infected mothersWestern blotHIV-1 infected cellsInterstitial pneumonitisInhibition antibodiesHIV-1Giant cellsIndicator cellsAntibodiesInfected cellsTitresChildrenCell linesCell spreadSerumReceptorsOutcomesVirusCellsPneumonitisThe Association of Epstein-Barr Virus with Lymphoproliferative Disorders: A Re-evaluation Using the Polymerase Chain Reaction
Pedneault L, Katz B, Miller G. The Association of Epstein-Barr Virus with Lymphoproliferative Disorders: A Re-evaluation Using the Polymerase Chain Reaction. Experimental Biology And Medicine 1991, 273-276. DOI: 10.1007/978-1-4612-0405-3_39.Peer-Reviewed Original Research
1987
Novel nuclear antigens recognized by human sera in lymphocytes latently infected by Epstein-Barr virus
Rowe D, Farrell P, Miller G. Novel nuclear antigens recognized by human sera in lymphocytes latently infected by Epstein-Barr virus. Virology 1987, 156: 153-162. PMID: 3027963, DOI: 10.1016/0042-6822(87)90446-6.Peer-Reviewed Original ResearchConceptsEBNA seraAntigen complexX50-7Immortalization of lymphocytesEpstein-Barr virusEBNA INovel nuclear antigenIV groupNew antigensNuclear antigenLymphocytesCell clonesWestern immunoblottingSerumCell linesEBVAntigenMolecular weight proteinsHuman serumHigh molecular weight proteinsRajiVirusViral genomeGroupWeight proteins
1984
Epstein-Barr virus with heterogeneous DNA disrupts latency
Miller G, Rabson M, Heston L. Epstein-Barr virus with heterogeneous DNA disrupts latency. Journal Of Virology 1984, 50: 174-182. PMID: 6321789, PMCID: PMC255597, DOI: 10.1128/jvi.50.1.174-182.1984.Peer-Reviewed Original ResearchConceptsEpstein-Barr virusLatent Epstein-Barr virusEarly antigenRaji cellsViral synthesisX50-7 cellsHet DNABurkitt lymphoma linesActivated virusEBV DNANeonatal lymphocytesEBV replicationEBV sequencesX50-7Restriction endonuclease polymorphismAntigenLymphoma linesVirusRare variantsDefective virusLower ratesSuperinfectionCell spreadBiological effectsCells
1983
Central-Nervous-System Lymphoma Related to Epstein–Barr Virus
Hochberg F, Miller G, Schooley R, Hirsch M, Feorino P, Henle W. Central-Nervous-System Lymphoma Related to Epstein–Barr Virus. New England Journal Of Medicine 1983, 309: 745-748. PMID: 6310394, DOI: 10.1056/nejm198309293091301.Peer-Reviewed Original ResearchConceptsEpstein-Barr virusCentral nervous systemSystem lymphomaPrimary lymphomaNervous systemEpstein-Barr virus-specific antibodiesEpstein-Barr virus infectionEpstein-Barr virus genomeRecent primary infectionAdjacent normal brain tissueVirus-specific antibodiesNormal brain tissueSystemic lymphomaBamHI K fragmentAdditional patientsSerologic evidenceOngoing infectionPrimary infectionVirus infectionLymphomaBrain tissueTumor tissueSerum samplesInfectionVirusIdentification of a rare Epstein-Barr virus variant that enhances early antigen expression in Raji cells.
Rabson M, Heston L, Miller G. Identification of a rare Epstein-Barr virus variant that enhances early antigen expression in Raji cells. Proceedings Of The National Academy Of Sciences Of The United States Of America 1983, 80: 2762-2766. PMID: 6302703, PMCID: PMC393908, DOI: 10.1073/pnas.80.9.2762.Peer-Reviewed Original Research
1982
Neutralization of lymphocyte immortalization by different strains of Epstein-Barr virus with a murine monoclonal antibody
Miller G, Heston L, Hoffman G. Neutralization of lymphocyte immortalization by different strains of Epstein-Barr virus with a murine monoclonal antibody. Infection And Immunity 1982, 37: 1028-1031. PMID: 6182100, PMCID: PMC347642, DOI: 10.1128/iai.37.3.1028-1031.1982.Peer-Reviewed Original ResearchConceptsEpstein-Barr virusMurine monoclonal antibodiesMonoclonal antibodiesCases of mononucleosisB95-8 strainBurkitt's lymphoma cell linesPolyclonal lymphomaBlood transfusionEBV strainsAmerican patientsChallenge virusLymphoma cell linesBurkitt's lymphomaLymphocyte immortalizationAfrican childrenHybridoma antibodiesAntigenic differencesAntibodiesMarmoset cellsMononucleosisVirusAntigenic sitesCell linesLymphomaAntigenNew Epstein–Barr virus variants from cellular subclones of P3J-HR-1 Burkitt lymphoma
Heston L, Rabson M, Brown N, Miller G. New Epstein–Barr virus variants from cellular subclones of P3J-HR-1 Burkitt lymphoma. Nature 1982, 295: 160-163. PMID: 6276755, DOI: 10.1038/295160a0.Peer-Reviewed Original Research
1981
Genome of a mononucleosis epstein-barr virus contains DNA fragments previously regarded to be unique to Burkitt's lymphoma isolates
Fischer D, Miller G, Gradoville L, Heston L, Weststrate M, Maris W, Wright J, Brandsma J, Summers W. Genome of a mononucleosis epstein-barr virus contains DNA fragments previously regarded to be unique to Burkitt's lymphoma isolates. Cell 1981, 24: 543-553. PMID: 6263500, DOI: 10.1016/0092-8674(81)90345-7.Peer-Reviewed Original ResearchConceptsBurkitt's lymphomaB95-8Infectious mononucleosisUncomplicated infectious mononucleosisEpstein-Barr virusSalivary isolatesEBV infectionDisease manifestationsLymphomaMononucleosisPatientsEBVRestriction enzyme analysisVirusMajor insertionC fragmentEnzyme analysisHr-1IsolatesInfectionDeletionAvailable virusEpstein-Barr Viral DNA: Infectivity for Human Placental Cells
Miller G, Grogan E, Heston L, Robinson J, Smith D. Epstein-Barr Viral DNA: Infectivity for Human Placental Cells. Science 1981, 212: 452-455. PMID: 6259735, DOI: 10.1126/science.6259735.Peer-Reviewed Original Research
1979
SITE OF EPSTEIN-BARR VIRUS REPLICATION IN THE OROPHARYNX
Morgan DG, Miller G, Niederman J, Smith HW, Dowaliby JM. SITE OF EPSTEIN-BARR VIRUS REPLICATION IN THE OROPHARYNX. The Lancet 1979, 314: 1154-1157. PMID: 91888, DOI: 10.1016/s0140-6736(79)92384-5.Peer-Reviewed Original ResearchConceptsInfectious Epstein-Barr virusEpstein-Barr virus replicationAcute infectious mononucleosisEpstein-Barr virusInfectious mononucleosisPatient's virusThroat washingsViral antigensEBV productionTonsillar lymphocytesInfectious virusVirus replicationParotid secretionPatientsCell-free formSalivary glandsOropharynxVirusSecretionCell-free materialSalivaMononucleosisCellsTonsillectomyLymphocytesExperimental Carcinogenicity by the Virus In Vivo
Miller G. Experimental Carcinogenicity by the Virus In Vivo. 1979, 351-372. DOI: 10.1007/978-3-642-67236-1_16.Peer-Reviewed Original ResearchEpstein-Barr virusEBV nuclear antigenBurkitt's lymphomaEBV DNA copiesHuman EBV infectionEBV infectionLymphoid folliclesLymphoproliferative syndromeMalignant diseaseGerminal centersLymphoid neoplasmsNew World primatesNuclear antigenSpectrum of responsesOwl monkeysLymphomaInfectionExperimental carcinogenicityVirusDNA copiesNeoplasmsSyndromeTumorsAntigenDisease
1976
Infectious Mononucleosis — Epstein–Barr-Virus Shedding in Saliva and the Oropharynx
Niederman J, Miller G, Pearson H, Pagano J, Dowaliby J. Infectious Mononucleosis — Epstein–Barr-Virus Shedding in Saliva and the Oropharynx. New England Journal Of Medicine 1976, 294: 1355-1359. PMID: 177872, DOI: 10.1056/nejm197606172942501.Peer-Reviewed Original ResearchConceptsThroat washingsDuct orificeEpstein-Barr virusDemonstration of virusOropharyngeal sitesInfectious mononucleosisOropharyngeal specimensThird monthIntermittent excretionExcretion patternsAge groupsSecond weekVirusPatientsMonthsOral secretionsSalivaMononucleosisOropharynxExcretionSwabsSecretionWeeks
1974
OROPHARYNGEAL EXCRETION OF EPSTEIN-BARR VIRUS BY RENAL TRANSPLANT RECIPIENTS AND OTHER PATIENTS TREATED WITH IMMUNOSUPPRESSIVE DRUGS
Strauch B, Siegel N, Andrews L, Miller G. OROPHARYNGEAL EXCRETION OF EPSTEIN-BARR VIRUS BY RENAL TRANSPLANT RECIPIENTS AND OTHER PATIENTS TREATED WITH IMMUNOSUPPRESSIVE DRUGS. The Lancet 1974, 303: 234-237. PMID: 4130246, DOI: 10.1016/s0140-6736(74)92546-x.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultAntibodies, ViralAzathioprineCarrier StateChildChild, PreschoolFemaleFluorescent Antibody TechniqueHerpesvirus 4, HumanHumansImmunity, CellularImmunosuppressive AgentsKidney TransplantationLeukocytesMaleMiddle AgedMouthMucusPharynxPostoperative CarePrednisoneProspective StudiesTherapeutic IrrigationTransplantation, HomologousConceptsEpstein-Barr virusImmunosuppressive drugsRenal homograftsRenal transplant recipientsOropharyngeal excretionShed virusVirus excretorsImmunosuppressive therapySeropositive patientsTransplant recipientsChronic uraemiaThroat washingsVirus 8Seropositive individualsThroat samplesVirus sheddingVirus infectionPatientsNuclear antigenHealthy staffLong-term proliferationDrugsVirusHomograftsTransplantation
1973
Malignant Lymphoma in Cottontop Marmosets after Inoculation with Epstein-Barr Virus
Shope T, Dechairo D, Miller G. Malignant Lymphoma in Cottontop Marmosets after Inoculation with Epstein-Barr Virus. Proceedings Of The National Academy Of Sciences Of The United States Of America 1973, 70: 2487-2491. PMID: 4354852, PMCID: PMC427039, DOI: 10.1073/pnas.70.9.2487.Peer-Reviewed Original ResearchConceptsEpstein-Barr virusMalignant lymphomaImmunosuppressive drugsCottontop marmosetsCell-free Epstein-Barr virusCourse of diseaseCell-free virusHuman malignant lymphomasSarcoma typesVirus antigenAddition of virusLymphomaAutologous cellsTumor formationLatent periodOncogenic capacityOrgan cultureMarmosetsVirusTumorsAntibodiesDrugsAdditional evidenceCellsNeoplasia