2019
Cellular Genes Involved in Redox Regulation Are Altered by Inhibitors of Epstein‐Barr Virus Lytic Gene Expression
Gorres K, Miller G. Cellular Genes Involved in Redox Regulation Are Altered by Inhibitors of Epstein‐Barr Virus Lytic Gene Expression. The FASEB Journal 2019, 33: 458.11-458.11. DOI: 10.1096/fasebj.2019.33.1_supplement.458.11.Peer-Reviewed Original ResearchViral lytic gene expressionLytic gene expressionCellular genesGene expressionViral lytic cycleLytic cycleEpstein-Barr virusNext-generation RNA sequencingViral immediate-early genesCellular gene expressionImmediate early genesRedox regulationTranscription factorsRNA sequencingCellular pathwaysGenesEnvironmental stimuliHuman cancersRedox statusMore virionsEBV-positive cellsFASEB JournalFull-text articlesExpressionViral lytic cascade
2001
CD4+ T-Cell Effectors Inhibit Epstein-Barr Virus-Induced B-Cell Proliferation
Nikiforow S, Bottomly K, Miller G. CD4+ T-Cell Effectors Inhibit Epstein-Barr Virus-Induced B-Cell Proliferation. Journal Of Virology 2001, 75: 3740-3752. PMID: 11264363, PMCID: PMC114865, DOI: 10.1128/jvi.75.8.3740-3752.2001.Peer-Reviewed Original ResearchMeSH KeywordsAdultB-LymphocytesCD4-Positive T-LymphocytesCD8-Positive T-LymphocytesCell DivisionCell SizeCells, CulturedEpstein-Barr Virus InfectionsEpstein-Barr Virus Nuclear AntigensFlow CytometryHerpesvirus 4, HumanHumansImmunologic MemoryLymphocyte CountReceptors, IgESerologyTacrolimusT-Lymphocyte SubsetsConceptsEpstein-Barr virusB cell proliferationT cellsB cellsB-cell lymphoproliferative diseaseRemoval of CD4Effector T cellsMemory T cellsT cell effectorsT cell surveillanceCytolytic T cellsEarly proliferative phaseCell linesImmune controlLymphoproliferative diseaseImmunodeficient hostsImmune surveillanceLymphoblastoid cell linesCD4Proliferative phaseImmortalized cell linesCD8CD23VirusInfection
1999
Amino Acid Substitutions Reveal Distinct Functions of Serine 186 of the ZEBRA Protein in Activation of Early Lytic Cycle Genes and Synergy with the Epstein-Barr Virus R Transactivator
Francis A, Ragoczy T, Gradoville L, Heston L, El-Guindy A, Endo Y, Miller G. Amino Acid Substitutions Reveal Distinct Functions of Serine 186 of the ZEBRA Protein in Activation of Early Lytic Cycle Genes and Synergy with the Epstein-Barr Virus R Transactivator. Journal Of Virology 1999, 73: 4543-4551. PMID: 10233912, PMCID: PMC112494, DOI: 10.1128/jvi.73.6.4543-4551.1999.Peer-Reviewed Original ResearchConceptsLytic cycle genesLatent virusZEBRA proteinOverexpression of RtaEpstein-Barr virusLatent EBV genomeBRLF1 expressionEarly lytic cycle genesAmino acid substitutionsEBV genomeBRLF1BRLF1 promoterCycle genesAcid substitutionsVirusEpstein-Barr virus R transactivatorSerine 186Distinct phenotypesLytic life cycleR transactivatorActivationDifferent amino acid substitutionsResponse elementS186Expression
1998
The Epstein-Barr Virus Rta Protein Activates Lytic Cycle Genes and Can Disrupt Latency in B Lymphocytes
Ragoczy T, Heston L, Miller G. The Epstein-Barr Virus Rta Protein Activates Lytic Cycle Genes and Can Disrupt Latency in B Lymphocytes. Journal Of Virology 1998, 72: 7978-7984. PMID: 9733836, PMCID: PMC110133, DOI: 10.1128/jvi.72.10.7978-7984.1998.Peer-Reviewed Original ResearchMeSH KeywordsBase SequenceB-LymphocytesCell LineChloramphenicol O-AcetyltransferaseDNA PrimersDNA ReplicationDNA-Binding ProteinsGene Expression Regulation, ViralHerpesvirus 4, HumanHumansImmediate-Early ProteinsPromoter Regions, GeneticTrans-ActivatorsTranscription FactorsViral ProteinsVirus LatencyConceptsEpstein-Barr virusLytic cycle genesB lymphocytesEpstein–Barr virus Rta proteinEpithelial cellsLytic cycleDisruption of latencyViral lytic cycleB cell linesEBV entryImmediate early viral genesBZLF1LymphocytesCycle genesExpression of RTARTA functionBRLF1Rta proteinDownstream targetsViral genesViral DNA replicationExpressionCellsA viral gene that activates lytic cycle expression of Kaposi’s sarcoma-associated herpesvirus
Sun R, Lin S, Gradoville L, Yuan Y, Zhu F, Miller G. A viral gene that activates lytic cycle expression of Kaposi’s sarcoma-associated herpesvirus. Proceedings Of The National Academy Of Sciences Of The United States Of America 1998, 95: 10866-10871. PMID: 9724796, PMCID: PMC27987, DOI: 10.1073/pnas.95.18.10866.Peer-Reviewed Original ResearchMeSH KeywordsAmino Acid SequenceBase SequenceCloning, MolecularDNA PrimersDNA, ComplementaryGene Expression Regulation, NeoplasticGenes, ViralHerpesvirus 4, HumanHerpesvirus 8, HumanHumansMolecular Sequence DataSarcoma, KaposiSequence Homology, Amino AcidTranscription, GeneticTumor Cells, CulturedVirus ActivationConceptsEpstein-Barr virusKaposi's sarcoma-associated herpesvirusSarcoma-associated herpesvirusSmall viral capsid antigenPathogenesis of KSHVLytic cycle gene expressionViral capsid antigenLatent viral genomeCapsid antigenLytic cycle genesInterleukin-6Immediate early genesViral cytokineEarly lytic genesLytic genesHerpesvirusVirusViral genesViral genomeExpressionGene expressionCytokinesPathogenesisCycle genesGenes
1997
The transcriptional activator Sp1, a novel autoantigen
Spain T, Sun R, Gradzka M, Lin S, Craft J, Miller G. The transcriptional activator Sp1, a novel autoantigen. Arthritis & Rheumatism 1997, 40: 1085-1095. PMID: 9182919, DOI: 10.1002/art.1780400613.Peer-Reviewed Original ResearchConceptsTranscriptional activator Sp1Novel autoantigenComplex of DNAGC-rich sequencesActivator Sp1Undifferentiated connective tissue diseaseSp1 proteinTranscription activatorConnective tissue diseaseExtractable nuclear antigensEpstein-Barr virusSp1Nuclear extractsCellular DNAMalar rashAntinuclear antibodiesClinical characteristicsProteinDNARaynaud's phenomenonTissue diseaseAutoantigenic proteinsAutoimmune seraElectrophoretic mobilityAutoantigens
1996
Antibodies to Butyrate-Inducible Antigens of Kaposi's Sarcoma–Associated Herpesvirus in Patients with HIV-1 Infection
Miller G, Rigsby M, Heston L, Grogan E, Sun R, Metroka C, Levy J, Gao S, Chang Y, Moore P. Antibodies to Butyrate-Inducible Antigens of Kaposi's Sarcoma–Associated Herpesvirus in Patients with HIV-1 Infection. New England Journal Of Medicine 1996, 334: 1292-1297. PMID: 8609946, DOI: 10.1056/nejm199605163342003.Peer-Reviewed Original ResearchConceptsHIV-1-infected patientsEpstein-Barr virusKaposi's sarcomaBC-1 cellsHuman immunodeficiency virus type 1 (HIV-1) infectionVirus type 1 infectionPositive serologic responseHIV-1 infectionType 1 infectionHigh-risk populationAntigen-positive cellsPresence of antibodiesPositive predictive valueEBV antigensKSHV antigensP40 antigenSerologic markersSerologic responseKaposi's Sarcoma-Associated HerpesvirusEtiologic roleSerologic testsPatientsSarcomaPredictive valueKSHV infection
1995
Transmissible Retrovirus in Epstein-Burr Virus-Producer B95-8 Cells
Sun R, Grogan E, Shedd D, Bykovsky A, Kushnaryov V, Grossberg S, Miller G. Transmissible Retrovirus in Epstein-Burr Virus-Producer B95-8 Cells. Virology 1995, 209: 374-383. PMID: 7778272, DOI: 10.1006/viro.1995.1269.Peer-Reviewed Original ResearchMeSH KeywordsAmino Acid SequenceAnimalsBase SequenceBetaretrovirusB-LymphocytesCallithrixCell LineCloning, MolecularDNA PrimersDNA, ComplementaryGene LibraryGene Products, gagGenes, gagHerpesvirus 4, HumanHumansMicroscopy, ElectronMolecular Sequence DataPolymerase Chain ReactionRepetitive Sequences, Nucleic AcidSaimiriT-LymphocytesVirus ReplicationConceptsEpstein-Barr virusB95-8 cellsAbsence of EBVCell linesB95-8 isolateB95-8 strainMarmoset cell linesHuman lymphoid cell linesT cell linesLymphoid cell linesType D retrovirusHuman BLymphocyte immortalizationInfectious virusViral replicationHuman isolatesGag regionBiologic propertiesTransmissible retrovirusUltrastructural appearanceD retrovirusesAmino acid changesVirusSMRVGag sequences
1992
Detection of Epstein‐Barr virus in the brain by the polymerase chain reaction
Pedneault L, Katz B, Miller G. Detection of Epstein‐Barr virus in the brain by the polymerase chain reaction. Annals Of Neurology 1992, 32: 184-192. PMID: 1324632, DOI: 10.1002/ana.410320210.Peer-Reviewed Original ResearchConceptsEpstein-Barr virusEBV DNAPolymerase chain reactionRole of EBVChain reactionCentral nervous system syndromeDiverse neurological syndromesKidney transplant recipientsHerpes group virusesTransplant recipientsMetabolic encephalopathiesBrain biopsyImmunodeficiency syndromeNeurological syndromeImmunodeficient hostsEBV genomeBrain specimensViral isolationPatientsGroup virusesSerological testsSyndromeBrainVirusEncephalitis
1991
The Association of Epstein-Barr Virus with Lymphoproliferative Disorders: A Re-evaluation Using the Polymerase Chain Reaction
Pedneault L, Katz B, Miller G. The Association of Epstein-Barr Virus with Lymphoproliferative Disorders: A Re-evaluation Using the Polymerase Chain Reaction. Experimental Biology And Medicine 1991, 273-276. DOI: 10.1007/978-1-4612-0405-3_39.Peer-Reviewed Original ResearchInteraction of EBV Genes with Human Epithelial Cells
Rhim J, Arnstein P, Fahraeus R, Rymo L, Klein G, Gradoville L, Miller G, Wang F, Kieff E. Interaction of EBV Genes with Human Epithelial Cells. Experimental Biology And Medicine 1991, 339-345. DOI: 10.1007/978-1-4612-0405-3_48.Peer-Reviewed Original ResearchLatent membrane proteinEpstein-Barr virusHuman epithelial cellsHuman epithelial cell systemsNasopharyngeal carcinomaEpithelial cell systemEBV genesEpithelial cellsVariety of retrovirusesMembrane proteinsEBV latent membrane proteinAd12-SV40 virusRodent cellsViral genesCell transformationDNA plasmid constructsPlasmid constructsGenesHuman epithelial malignanciesMechanism of actionOncogene transfectionLMP genesEpithelial malignanciesPrecise roleEBNA-2
1988
THE FREQUENCY OF EPSTEIN-BARR VIRUS INFECTION AND ASSOCIATED LYMPHOPROLIFERATIVE SYNDROME AFTER TRANSPLANTATION AND ITS MANIFESTATIONS IN CHILDREN
Ho M, Jaffe R, Miller G, Breinig M, Dummer J, Makowka L, Atchison R, Karrer F, Nalesnik M, Starzl T. THE FREQUENCY OF EPSTEIN-BARR VIRUS INFECTION AND ASSOCIATED LYMPHOPROLIFERATIVE SYNDROME AFTER TRANSPLANTATION AND ITS MANIFESTATIONS IN CHILDREN. Transplantation 1988, 45: 719-726. PMID: 2833828, PMCID: PMC2993427, DOI: 10.1097/00007890-198804000-00011.Peer-Reviewed Original ResearchConceptsLymphoproliferative syndromePrimary infectionEBV infectionTransplant recipientsEpstein-Barr virus infectionMonoclonal B-cell lymphomaPediatric liver recipientsPrimary EBV infectionPediatric transplant recipientsEpstein-Barr virusEBV nuclear antigenB-cell lymphomaLiver recipientsPediatric EBVCyclosporine monitoringEBV DNAClinical typesPediatric casesSecond syndromeVirus infectionCell lymphomaAdditional casesGreater riskInfectionNuclear antigen
1987
Novel nuclear antigens recognized by human sera in lymphocytes latently infected by Epstein-Barr virus
Rowe D, Farrell P, Miller G. Novel nuclear antigens recognized by human sera in lymphocytes latently infected by Epstein-Barr virus. Virology 1987, 156: 153-162. PMID: 3027963, DOI: 10.1016/0042-6822(87)90446-6.Peer-Reviewed Original ResearchConceptsEBNA seraAntigen complexX50-7Immortalization of lymphocytesEpstein-Barr virusEBNA INovel nuclear antigenIV groupNew antigensNuclear antigenLymphocytesCell clonesWestern immunoblottingSerumCell linesEBVAntigenMolecular weight proteinsHuman serumHigh molecular weight proteinsRajiVirusViral genomeGroupWeight proteins
1986
Primary central nervous system lymphoma related to Epstein‐Barr virus in a patient with acquired immune deficiency syndrome
Rosenberg N, Hochberg F, Miller G, Kleinschmidt‐DeMasters B. Primary central nervous system lymphoma related to Epstein‐Barr virus in a patient with acquired immune deficiency syndrome. Annals Of Neurology 1986, 20: 98-102. PMID: 3017188, DOI: 10.1002/ana.410200118.Peer-Reviewed Original ResearchConceptsCentral nervous system lymphomaEpstein-Barr virus infectionNervous system lymphomaImmune deficiency syndromeSystem lymphomaDeficiency syndromeVirus infectionPrimary central nervous system lymphomaEpstein-Barr virus genomeEpstein-Barr virusCentral nervous systemPrimary lymphomaNervous systemTumor tissueLymphomaPatientsSyndromeInfectionAcid preparationsHybridization studiesDeoxyribonucleic acid preparationsVirus genomeK fragmentProgressive Epstein-Barr Virus Infection
Andiman W, Katz B, Miller G. Progressive Epstein-Barr Virus Infection. 1986, 276-286. DOI: 10.1007/978-1-4612-4958-0_33.Peer-Reviewed Original ResearchEpstein-Barr virusInfectious mononucleosisEpstein-Barr virus infectionDisorders of immunitySpectrum of diseaseEBV infectionImmunologic controlFatal syndromeVirus infectionClinical conditionsNosologic entityB cellsViral replicationInfectionMononucleosisDiseaseAbnormal degreeUnchecked proliferationImmunopathogenesisRelapsingNeoplasiaSyndromeAntigenImmunity
1985
Identification and expression of a nuclear antigen from the genomic region of the Jijoye strain of Epstein-Barr virus that is missing in its nonimmortalizing deletion mutant, P3HR-1.
Rowe D, Heston L, Metlay J, Miller G. Identification and expression of a nuclear antigen from the genomic region of the Jijoye strain of Epstein-Barr virus that is missing in its nonimmortalizing deletion mutant, P3HR-1. Proceedings Of The National Academy Of Sciences Of The United States Of America 1985, 82: 7429-7433. PMID: 2997790, PMCID: PMC391358, DOI: 10.1073/pnas.82.21.7429.Peer-Reviewed Original ResearchConceptsChronic active EBV infectionActive EBV infectionEpstein-Barr virusJijoye strainEBV infectionEBV DNACertain patientsP3HR-1Human antiseraVirus strainsNuclear antigenHr-1JijoyeVirus deletion mutantsLtk- cellsMouse Ltk- cellsImmortalization processPatientsGene transferNeoantigensLymphocytesInfectionAntigenEpstein-Barr Virus Genomes Are Restricted to Secondary Neoplastic Cells Following Bone Marrow Transplantation
Schubach W, Miller G, Thomas E. Epstein-Barr Virus Genomes Are Restricted to Secondary Neoplastic Cells Following Bone Marrow Transplantation. Blood 1985, 65: 535-538. DOI: 10.1182/blood.v65.3.535.535.Peer-Reviewed Original ResearchBone marrow transplantationEpstein-Barr virusMarrow transplantationB-cell neoplasmsEBV genomeCell neoplasmsEpstein-Barr virus genomeLong-term remissionGroup of patientsCells of patientsEngrafted lymphocytesMononuclear bloodRecurrent leukemiaSecondary neoplasmsMononuclear cellsOriginal leukemiaPatient categoriesNeoplastic cellsPatientsTumor cellsTransplantationNeoplasmsLeukemiaCellsVirus genomeConstitutive expression of Epstein-Barr virus-encoded RNAs and nuclear antigen during latency and after induction of Epstein-Barr virus replication
Weigel R, Fischer D, Heston L, Miller G. Constitutive expression of Epstein-Barr virus-encoded RNAs and nuclear antigen during latency and after induction of Epstein-Barr virus replication. Journal Of Virology 1985, 53: 254-259. PMID: 2981344, PMCID: PMC255024, DOI: 10.1128/jvi.53.1.254-259.1985.Peer-Reviewed Original ResearchConceptsEpstein-Barr virus-encoded RNAVirus-encoded RNAEpstein-Barr virus replicationNuclear antigenEpstein-Barr virusLatent gene productsEpstein-Barr virus gene productsHR-1 cellsVirus gene productsViral variantsVirus replicationAntigen mRNAAbsence of inductionViral DNAAntigenInductionMethod of inductionPhorbol esterViral polypeptidesViral transcriptsGene productsCytoplasmic abundanceExpressionConstitutive expressionConstitutive levels
1984
Epstein-Barr virus with heterogeneous DNA disrupts latency
Miller G, Rabson M, Heston L. Epstein-Barr virus with heterogeneous DNA disrupts latency. Journal Of Virology 1984, 50: 174-182. PMID: 6321789, PMCID: PMC255597, DOI: 10.1128/jvi.50.1.174-182.1984.Peer-Reviewed Original ResearchConceptsEpstein-Barr virusLatent Epstein-Barr virusEarly antigenRaji cellsViral synthesisX50-7 cellsHet DNABurkitt lymphoma linesActivated virusEBV DNANeonatal lymphocytesEBV replicationEBV sequencesX50-7Restriction endonuclease polymorphismAntigenLymphoma linesVirusRare variantsDefective virusLower ratesSuperinfectionCell spreadBiological effectsCells
1983
Central-Nervous-System Lymphoma Related to Epstein–Barr Virus
Hochberg F, Miller G, Schooley R, Hirsch M, Feorino P, Henle W. Central-Nervous-System Lymphoma Related to Epstein–Barr Virus. New England Journal Of Medicine 1983, 309: 745-748. PMID: 6310394, DOI: 10.1056/nejm198309293091301.Peer-Reviewed Original ResearchConceptsEpstein-Barr virusCentral nervous systemSystem lymphomaPrimary lymphomaNervous systemEpstein-Barr virus-specific antibodiesEpstein-Barr virus infectionEpstein-Barr virus genomeRecent primary infectionAdjacent normal brain tissueVirus-specific antibodiesNormal brain tissueSystemic lymphomaBamHI K fragmentAdditional patientsSerologic evidenceOngoing infectionPrimary infectionVirus infectionLymphomaBrain tissueTumor tissueSerum samplesInfectionVirus