2004
Time course of the effects of the serotonin-selective reuptake inhibitor sertraline on central and peripheral serotonin neurochemistry in the rhesus monkey
Anderson GM, Barr CS, Lindell S, Durham AC, Shifrovich I, Higley JD. Time course of the effects of the serotonin-selective reuptake inhibitor sertraline on central and peripheral serotonin neurochemistry in the rhesus monkey. Psychopharmacology 2004, 178: 339-346. PMID: 15452685, DOI: 10.1007/s00213-004-2011-7.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsBrainHomovanillic AcidHydroxyindoleacetic AcidMacaca mulattaMaleReference ValuesSelective Serotonin Reuptake InhibitorsSerotoninSertralineTryptophanConceptsSelective serotonin reuptake inhibitorsCisternal cerebrospinal fluid (CSF) samplesPg/Young adult male rhesus monkeysRhesus monkeysSerotonin reuptake inhibitorsAdult male rhesus monkeysPlasma drug levelsCerebrospinal fluid samplesExtent of elevationMale rhesus monkeysTime courseNon-human primatesAutoreceptor desensitizationSerotonin neurochemistryReuptake inhibitorsNeurochemical effectsResponse latencyProlonged administrationDrug levelsDrug accumulationDay 0SertralineDiscontinuationBaseline
1998
Tryptophan Depletion During Continuous CSF Sampling in Healthy Human Subjects
Carpenter L, Anderson G, Pelton G, Gudin J, Kirwin P, Price L, Heninger G, McDougle C. Tryptophan Depletion During Continuous CSF Sampling in Healthy Human Subjects. Neuropsychopharmacology 1998, 19: 26-35. PMID: 9608574, DOI: 10.1016/s0893-133x(97)00198-x.Peer-Reviewed Original ResearchConceptsAmino acid drinkCerebrospinal fluidAcid drinkTRP levelsLow TRP dietTryptophan depletion paradigmBrain serotonin levelsPlasma TRP levelsHealthy adult subjectsHealthy human subjectsCSF TRP levelsPlasma TrpIndwelling catheterLumbar punctureSerotonin levelsTryptophan depletionContinuous cerebrospinal fluidSpecial dietAdult subjectsBehavioral effectsPlasma samplesHuman subjectsCorresponding fallCentral levelNadir
1997
Assessment of diurnal variation of cerebrospinal fluid tryptophan and 5-hydroxyindoleacetic acid in healthy human females
Kirwin P, Anderson G, Chappell P, Saberski L, Leckman J, Geracioti T, Heninger G, Price L, McDougle C. Assessment of diurnal variation of cerebrospinal fluid tryptophan and 5-hydroxyindoleacetic acid in healthy human females. Life Sciences 1997, 60: 899-907. PMID: 9061047, DOI: 10.1016/s0024-3205(97)00021-0.Peer-Reviewed Original ResearchMeSH KeywordsAdultCatheters, IndwellingCircadian RhythmFemaleHumansHydroxyindoleacetic AcidTryptophanConceptsCSF samplingCSF tryptophanNeuropsychiatric illnessCerebrospinal fluid tryptophanMultiple lumbar puncturesCerebrospinal fluid levelsPlasma TRP levelsRole of serotoninHealthy female volunteersLevels of tryptophanMajor neuropsychiatric disordersIntra-individual coefficientContinuous CSFCSF neurochemistryLumbar catheterLumbar puncturePlasma tryptophanHealthy subjectsTRP levelsFemale volunteersHealthy human femalesFluid levelsNeuropsychiatric disordersAnxiety disordersCSF
1994
Elevated Cerebrospinal Fluid Levels of Oxytocin in Obsessive-compulsive Disorder: Comparison With Tourette's Syndrome and Healthy Controls
Leckman J, Goodman W, North W, Chappell P, Price L, Pauls D, Anderson G, Riddle M, McSwiggan-Hardin M, McDougle C, Barr L, Cohen D. Elevated Cerebrospinal Fluid Levels of Oxytocin in Obsessive-compulsive Disorder: Comparison With Tourette's Syndrome and Healthy Controls. JAMA Psychiatry 1994, 51: 782-792. PMID: 7524462, DOI: 10.1001/archpsyc.1994.03950100030003.Peer-Reviewed Original ResearchConceptsCerebrospinal fluid levelsObsessive-compulsive disorderCSF oxytocin levelsTourette syndromeArginine vasopressinFamily historyFluid levelsElevated cerebrospinal fluid levelsTic-related obsessive-compulsive disorderOxytocin levelsSubgroup of patientsSubset of patientsElevated CSF levelsCentral arginine vasopressinSubtype of OCDCSF levelsFamily genetic dataHealthy controlsTic disordersForms of OCDPatientsRelated syndromesCurrent severitySyndromeFamily study dataAspartame, behavior, and cognitive function in children with attention deficit disorder.
Shaywitz B, Sullivan C, Anderson G, Gillespie S, Sullivan B, Shaywitz S. Aspartame, behavior, and cognitive function in children with attention deficit disorder. Pediatrics 1994, 93: 70-5. PMID: 7505423, DOI: 10.1542/peds.93.1.70.Peer-Reviewed Original ResearchConceptsAttention deficit disorderWisconsin Card Sorting TestDeficit disorderTreatment Emergent Symptom ScalePlacebo-controlled crossover studyComplete blood cell countStudy centersLiver function testsUrinary excretion rateBlood cell countAdministration of aspartameMental Disorders criteriaCognitive testsMeasurement of catecholaminesCrossover studyFunction testsMonoamine metabolismInpatient admissionsMetabolite excretionLarge dosesSymptom ScaleUsual consumptionCell countPlasma phenylalanineBiochemical measures
1993
Cerebrospinal fluid levels of homovanillic acid and 5-hydroxyindoleacetic acid in autism
Narayan M, Srinath S, Anderson G, Meundi DB. Cerebrospinal fluid levels of homovanillic acid and 5-hydroxyindoleacetic acid in autism. Biological Psychiatry 1993, 33: 630-635. PMID: 7687150, DOI: 10.1016/0006-3223(93)90102-j.Peer-Reviewed Original ResearchMeSH KeywordsAutistic DisorderChildChild, PreschoolFemaleHomovanillic AcidHumansHydroxyindoleacetic AcidMalePsychiatric Status Rating ScalesConceptsCSF homovanillic acidHomovanillic acidCerebrospinal fluid concentrationsCerebrospinal fluid levelsDopamine turnoverDopamine metabolitesCentral serotoninControl groupFluid levelsFluid concentrationsMarked alterationsGroup differencesAutistic disorderAutistic subjectsSerotoninChildrenAutistic childrenAlterationsGroupAutismPrevious studies
1992
Brain Monoamines and Amino Acids in Gilles de la Tourette's Syndrome: A Preliminary Study of Subcortical Regions
Anderson G, Pollak E, CHATTERJEE D, Leckman J, Riddle M, Cohen D. Brain Monoamines and Amino Acids in Gilles de la Tourette's Syndrome: A Preliminary Study of Subcortical Regions. JAMA Psychiatry 1992, 49: 584-586. PMID: 1378261, DOI: 10.1001/archpsyc.1992.01820070078016.Peer-Reviewed Original ResearchConceptsGilles de la Tourette's syndromeLateral globus pallidusSubstantia nigra reticulataMedial globus pallidusLa Tourette's syndromeTourette syndromeGlobus pallidusSubthalamic nucleusSubcortical regionsTS groupMajor projection areaPossible pathophysiologic significanceLevels of monoaminesNeurotransmitter-related enzymesLow TS groupBrains of subjectsBrain monoaminesMonoamine metabolitesPathophysiologic significanceControl groupPostmortem tissueSyndromeBrainAvailable brainPallidus
1990
Low CSF 5HIAA and obsessions of violence: Report of two cases
Leckman J, Goodman W, Riddle M, Hardin M, Anderson G. Low CSF 5HIAA and obsessions of violence: Report of two cases. Psychiatry Research 1990, 33: 95-99. PMID: 1699245, DOI: 10.1016/0165-1781(90)90152-u.Peer-Reviewed Original Research
1987
Urinary 5-hydroxyindoleacetic acid and whole blood serotonin and tryptophan in autistic and normal subjects
Minderaa R, Anderson G, Volkmar F, Akkerhuis G, Cohen D. Urinary 5-hydroxyindoleacetic acid and whole blood serotonin and tryptophan in autistic and normal subjects. Biological Psychiatry 1987, 22: 933-940. PMID: 2440483, DOI: 10.1016/0006-3223(87)90002-3.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultAutistic DisorderFemaleHumansHydroxyindoleacetic AcidMaleSerotoninTryptophanSerotonin in cisternal cerebrospinal fluid of the rat: Measurement and use as an index of functionally active serotonin
Anderson G, Teff K, Young S. Serotonin in cisternal cerebrospinal fluid of the rat: Measurement and use as an index of functionally active serotonin. Life Sciences 1987, 40: 2253-2260. PMID: 2438530, DOI: 10.1016/0024-3205(87)90061-0.Peer-Reviewed Original Research
1986
Cerebrospinal fluid monoamine precursor and metabolite levels in children treated for leukemia: Age and sex effects and individual variability
Riddle M, Anderson G, McIntosh S, Harcherik D, Shaywitz B, Cohen D. Cerebrospinal fluid monoamine precursor and metabolite levels in children treated for leukemia: Age and sex effects and individual variability. Biological Psychiatry 1986, 21: 69-83. PMID: 2417634, DOI: 10.1016/0006-3223(86)90009-0.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAge FactorsChildChild, PreschoolFemaleHomovanillic AcidHumansHydroxyindoleacetic AcidInfantLeukemia, LymphoidMaleSex FactorsTryptophanTyrosineConceptsAcute lymphoblastic leukemiaMetabolite homovanillic acidHomovanillic acidMonoamine precursorsCerebrospinal fluidLevels of HVALumbar cerebrospinal fluidCNS traumaCSF levelsLymphoblastic leukemiaMonoamine systemsCSF samplesChronic effectsSignificant sex differencesMetabolite levelsSignificant correlationLeukemiaSex differencesChildrenIndividual variabilityAgeSex effectsTreatmentLevelsMean coefficient
1985
NEUROTRANSMITTER PRECURSORS and METABOLITES IN CSF OF HUMAN NEONATES
Anderson G, Hoder E, Shaywitz B, Cohen D. NEUROTRANSMITTER PRECURSORS and METABOLITES IN CSF OF HUMAN NEONATES. Developmental Medicine & Child Neurology 1985, 27: 207-214. PMID: 2581835, DOI: 10.1111/j.1469-8749.1985.tb03771.x.Peer-Reviewed Original ResearchConceptsHuman neonatesAmino acid precursor tryptophanSignificant subgroup differencesMedical complicationsHomovanillic acidCerebrospinal fluidNeurotransmitter precursorsPrecursor tryptophanNeurotransmitter serotoninOlder childrenMajor metaboliteComplicated groupLatter groupComplicationsSignificant correlationNeonatesSubgroup differencesInfantsPhysiological measuresGroupMetabolitesLarge groupHigh levelsMedicationsNorepinephrineTwo-dimensional high-performance liquid chromatographic determination of 5-hydroxyindoleacetic acid and homovanillic acid in urine
Anderson G, Schlicht K, Cohen D. Two-dimensional high-performance liquid chromatographic determination of 5-hydroxyindoleacetic acid and homovanillic acid in urine. Analytical Biochemistry 1985, 144: 27-31. PMID: 2580456, DOI: 10.1016/0003-2697(85)90079-x.Peer-Reviewed Original ResearchMeSH KeywordsChemical PhenomenaChemistryChromatography, High Pressure LiquidHomovanillic AcidHumansHydroxyindoleacetic AcidPhenylacetatesEffect of a Meal on Human Whole Blood Serotonin
Anderson G, Feibel F, Wetlaufer L, Schlicht K, Ort S, Cohen D. Effect of a Meal on Human Whole Blood Serotonin. Gastroenterology 1985, 88: 86-89. PMID: 2578039, DOI: 10.1016/s0016-5085(85)80137-2.Peer-Reviewed Original ResearchMeSH KeywordsAdultChromatography, High Pressure LiquidFeeding BehaviorFemaleHumansHydroxyindoleacetic AcidMaleReference ValuesSerotoninTime FactorsTryptophanConceptsWhole blood serotoninMicrograms/hBlood serotoninGastrointestinal hormonesUrinary excretionSerotonin levelsBlood samplesUrine specimensBaseline levelsSerotoninSecond hourWhole bloodHuman subjectsSpecific high-performance liquid chromatographic methodMealMinSubjectsUrinaryLevelsExcretionBloodHormone
1983
Comparison of high-performance liquid chromatographic, gas chromatographic—mass spectrometric, and fluorometric methods for the determination of homovanillic acid and 5-hydroxyindoleacetic acid in human cerebrospinal fluid
Anderson G, Bowers M, Roth R, Young J, Hrbek C, Cohen D. Comparison of high-performance liquid chromatographic, gas chromatographic—mass spectrometric, and fluorometric methods for the determination of homovanillic acid and 5-hydroxyindoleacetic acid in human cerebrospinal fluid. Journal Of Chromatography 1983, 277: 282-286. PMID: 6196374, DOI: 10.1016/s0378-4347(00)84845-8.Peer-Reviewed Original Research
1982
Clinical neurochemistry of autism and associated disorders
Young J, Kavanagh M, Anderson G, Shaywitz B, Cohen D. Clinical neurochemistry of autism and associated disorders. Journal Of Autism And Developmental Disorders 1982, 12: 147-165. PMID: 6184361, DOI: 10.1007/bf01531305.Peer-Reviewed Original ResearchConceptsNorepinephrine metabolismNeurochemical methodsClinical neurochemistryClinical studiesNeurochemical studiesBehavioral deficitsBiochemical dysfunctionBrain functionAutistic syndromeInfantile autismLow levelsNew studiesAutismDysfunctionSerotoninSyndromeAutistic individualsSymptomsNeurochemistryBrainMajor obstacleDetermination of indoles in human and rat pineal
Anderson G, Young J, Cohen D, Young S. Determination of indoles in human and rat pineal. Journal Of Chromatography 1982, 228: 155-163. PMID: 6176588, DOI: 10.1016/s0378-4347(00)80428-4.Peer-Reviewed Original ResearchAssessment of Brain Function in Clinical Pediatric Research: Behavioral and Biological Strategies
Young J, Cohen D, Shaywitz S, Caparulo B, Kavanagh M, Hunt R, Leckman J, Anderson G, Detlor J, Harcherik D, Shaywitz B. Assessment of Brain Function in Clinical Pediatric Research: Behavioral and Biological Strategies. Schizophrenia Bulletin 1982, 8: 205-235. PMID: 6180470, DOI: 10.1093/schbul/8.2.205.Peer-Reviewed Original ResearchConceptsBrain functionPharmacological challenge testsSerious neuropsychiatric disorderClinical pediatric researchClinical research methodsSpecific neuronal systemsAttention deficit disorderClinical syndromeMetabolic dysfunctionTourette syndromeChallenge testClinical protocolsNew treatmentsClinical disordersNeuropsychiatric disordersNeuronal systemsClinical researchPediatric researchSyndromeDeficit disorderBest treatmentDisordersNovel biological strategiesLanguage disordersChildrenFactors Influencing Melatonin, 5-Hydroxytryptophol, 5-Hydroxyindoleacetic Acid, 5-Hydroxytryptamine and Tryptophan in Rat Pineal Glands
Young S, Anderson G. Factors Influencing Melatonin, 5-Hydroxytryptophol, 5-Hydroxyindoleacetic Acid, 5-Hydroxytryptamine and Tryptophan in Rat Pineal Glands. Neuroendocrinology 1982, 35: 464-468. PMID: 6185873, DOI: 10.1159/000123423.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsCircadian RhythmHydroxyindoleacetic AcidHydroxytryptopholIndolesLightMaleMelatoninPineal GlandRatsRats, Inbred StrainsSerotoninTryptophanDetermination of Neurochemically Important Compounds in Physiological Samples Using HPLC
Anderson G, Young J. Determination of Neurochemically Important Compounds in Physiological Samples Using HPLC. Schizophrenia Bulletin 1982, 8: 333-348. PMID: 6180473, DOI: 10.1093/schbul/8.2.333.Peer-Reviewed Original Research