1983
Dopaminergic but not noradrenergic mediation of hyperactivity and performance deficits in the developing rat pup
Shaywitz B, Teicher M, Cohen D, Anderson G, Young J, Levitt P. Dopaminergic but not noradrenergic mediation of hyperactivity and performance deficits in the developing rat pup. Psychopharmacology 1983, 82: 73-77. PMID: 6420833, DOI: 10.1007/bf00426384.Peer-Reviewed Original ResearchConceptsRat pupsDays of ageMotor activityBehavioral arousalPostsynaptic dopaminergic mechanismsReduction of norepinephrineReduction of dopamineGeneral motor activityMesolimbic dopaminergic pathwayDopaminergic mechanismsBrain dopaminePreferential reductionEscape latencyNoradrenergic mediationNorepinephrinePostnatal lifeWeek 3PupsSuch treatmentDopamineT-mazeShuttle boxAgeDesmethylimipraminePerformance deficitsDifferential effects of selective dopamine, norepinephrine or catecholamine depletion on activity and learning in the developing rat
Raskin L, Shaywitz B, Anderson G, Cohen D, Teicher M, Linakis J. Differential effects of selective dopamine, norepinephrine or catecholamine depletion on activity and learning in the developing rat. Pharmacology Biochemistry And Behavior 1983, 19: 743-749. PMID: 6647508, DOI: 10.1016/0091-3057(83)90073-4.Peer-Reviewed Original ResearchConceptsDays of ageT-mazeCentral catecholamine systemsSelective dopamine depletionSelective norepinephrine depletionDopamine depletionNE levelsNorepinephrine depletionCatecholamine depletionSevere learning impairmentIntraperitoneal injectionCatecholamine systemsSelective lesionsDay 28Selective dopamineNeonatal depletionLearning impairmentSelective depletionCatecholaminesClinical researchBehavioral effectsDeficit disorderShuttlebox performanceActivity levelsConstellation of behaviors
1982
Environmental and biologic interactions on behavior: Effects of artificial rearing in rat pups treated with 6‐hydroxydopamine
Goldenring J, Shaywitz B, Wool R, Batter D, Anderson G, Cohen D. Environmental and biologic interactions on behavior: Effects of artificial rearing in rat pups treated with 6‐hydroxydopamine. Developmental Psychobiology 1982, 15: 297-307. PMID: 6809512, DOI: 10.1002/dev.420150403.Peer-Reviewed Original Research
1981
Effects of bromocriptine in developing rat pups after 6-hydroxydopamine
Shaywitz B, Lipton S, Teicher M, Cohen D, Anderson G, Batter D, Young J. Effects of bromocriptine in developing rat pups after 6-hydroxydopamine. Pharmacology Biochemistry And Behavior 1981, 15: 443-448. PMID: 6794039, DOI: 10.1016/0091-3057(81)90275-6.Peer-Reviewed Original ResearchConceptsVehicle pupsHigh dosesDays of ageRat pupsCombination of desmethylimipramineInhibitory dopaminergic mechanismDoses of bromocriptineEffects of bromocriptineLittle clinical utilityGeneral motor activityAttention deficit disorderHole boxVehicle animalsDenervation supersensitivityDopaminergic mechanismsBrain dopamineClinical syndromeCommon disorderBromocriptineClinical utilityLonger observation periodPharmacological agentsPostnatal lifeMotor activityFirst month