2004
Time course of the effects of the serotonin-selective reuptake inhibitor sertraline on central and peripheral serotonin neurochemistry in the rhesus monkey
Anderson GM, Barr CS, Lindell S, Durham AC, Shifrovich I, Higley JD. Time course of the effects of the serotonin-selective reuptake inhibitor sertraline on central and peripheral serotonin neurochemistry in the rhesus monkey. Psychopharmacology 2004, 178: 339-346. PMID: 15452685, DOI: 10.1007/s00213-004-2011-7.Peer-Reviewed Original ResearchConceptsSelective serotonin reuptake inhibitorsCisternal cerebrospinal fluid (CSF) samplesPg/Young adult male rhesus monkeysRhesus monkeysSerotonin reuptake inhibitorsAdult male rhesus monkeysPlasma drug levelsCerebrospinal fluid samplesExtent of elevationMale rhesus monkeysTime courseNon-human primatesAutoreceptor desensitizationSerotonin neurochemistryReuptake inhibitorsNeurochemical effectsResponse latencyProlonged administrationDrug levelsDrug accumulationDay 0SertralineDiscontinuationBaseline
1998
Peripheral serotonin measures in prepubertal psychiatric inpatients and normal children: associations with suicidal behavior and its risk factors
Pfeffer C, McBride P, Anderson G, Kakuma T, Fensterheim L, Khait V. Peripheral serotonin measures in prepubertal psychiatric inpatients and normal children: associations with suicidal behavior and its risk factors. Biological Psychiatry 1998, 44: 568-577. PMID: 9787881, DOI: 10.1016/s0006-3223(98)00020-1.Peer-Reviewed Original ResearchConceptsPrepubertal psychiatric inpatientsBlood tryptophanRisk factorsSerotonin contentSuicidal behaviorMood disordersNormal controlsInpatient childrenSuicidal ideationSerotonin-amplified platelet aggregationPsychiatric inpatientsSuicide attemptsPlatelet serotonin contentEthnic differencesRecent suicide attemptSerotonin measuresPrepubertal controlsPlatelet serotoninPrepubertal childrenInpatientsPlatelet aggregationNormal childrenWhole bloodChildrenDisordersTryptophan Depletion During Continuous CSF Sampling in Healthy Human Subjects
Carpenter L, Anderson G, Pelton G, Gudin J, Kirwin P, Price L, Heninger G, McDougle C. Tryptophan Depletion During Continuous CSF Sampling in Healthy Human Subjects. Neuropsychopharmacology 1998, 19: 26-35. PMID: 9608574, DOI: 10.1016/s0893-133x(97)00198-x.Peer-Reviewed Original ResearchConceptsAmino acid drinkCerebrospinal fluidAcid drinkTRP levelsLow TRP dietTryptophan depletion paradigmBrain serotonin levelsPlasma TRP levelsHealthy adult subjectsHealthy human subjectsCSF TRP levelsPlasma TrpIndwelling catheterLumbar punctureSerotonin levelsTryptophan depletionContinuous cerebrospinal fluidSpecial dietAdult subjectsBehavioral effectsPlasma samplesHuman subjectsCorresponding fallCentral levelNadir
1997
Assessment of diurnal variation of cerebrospinal fluid tryptophan and 5-hydroxyindoleacetic acid in healthy human females
Kirwin P, Anderson G, Chappell P, Saberski L, Leckman J, Geracioti T, Heninger G, Price L, McDougle C. Assessment of diurnal variation of cerebrospinal fluid tryptophan and 5-hydroxyindoleacetic acid in healthy human females. Life Sciences 1997, 60: 899-907. PMID: 9061047, DOI: 10.1016/s0024-3205(97)00021-0.Peer-Reviewed Original ResearchMeSH KeywordsAdultCatheters, IndwellingCircadian RhythmFemaleHumansHydroxyindoleacetic AcidTryptophanConceptsCSF samplingCSF tryptophanNeuropsychiatric illnessCerebrospinal fluid tryptophanMultiple lumbar puncturesCerebrospinal fluid levelsPlasma TRP levelsRole of serotoninHealthy female volunteersLevels of tryptophanMajor neuropsychiatric disordersIntra-individual coefficientContinuous CSFCSF neurochemistryLumbar catheterLumbar puncturePlasma tryptophanHealthy subjectsTRP levelsFemale volunteersHealthy human femalesFluid levelsNeuropsychiatric disordersAnxiety disordersCSFA preliminary study of tryptophan depletion on tics, obsessive-compulsive symptoms, and mood in Tourette's syndrome
Rasmusson A, Anderson G, Lynch K, McSwiggan-Hardin M, Scahill L, Mazure C, Goodman W, Price L, Cohen D, Leckman J. A preliminary study of tryptophan depletion on tics, obsessive-compulsive symptoms, and mood in Tourette's syndrome. Biological Psychiatry 1997, 41: 117-121. PMID: 8988803, DOI: 10.1016/s0006-3223(96)00380-0.Peer-Reviewed Original Research
1994
Elevated Cerebrospinal Fluid Levels of Oxytocin in Obsessive-compulsive Disorder: Comparison With Tourette's Syndrome and Healthy Controls
Leckman J, Goodman W, North W, Chappell P, Price L, Pauls D, Anderson G, Riddle M, McSwiggan-Hardin M, McDougle C, Barr L, Cohen D. Elevated Cerebrospinal Fluid Levels of Oxytocin in Obsessive-compulsive Disorder: Comparison With Tourette's Syndrome and Healthy Controls. JAMA Psychiatry 1994, 51: 782-792. PMID: 7524462, DOI: 10.1001/archpsyc.1994.03950100030003.Peer-Reviewed Original ResearchConceptsCerebrospinal fluid levelsObsessive-compulsive disorderCSF oxytocin levelsTourette syndromeArginine vasopressinFamily historyFluid levelsElevated cerebrospinal fluid levelsTic-related obsessive-compulsive disorderOxytocin levelsSubgroup of patientsSubset of patientsElevated CSF levelsCentral arginine vasopressinSubtype of OCDCSF levelsFamily genetic dataHealthy controlsTic disordersForms of OCDPatientsRelated syndromesCurrent severitySyndromeFamily study data
1992
Tryptophan loading in hyperserotonemic and normoserotonemic adults
Cook E, Anderson G, Heninger G, Fletcher K, Freedman D, Leventhal B. Tryptophan loading in hyperserotonemic and normoserotonemic adults. Biological Psychiatry 1992, 31: 525-528. PMID: 1581428, DOI: 10.1016/0006-3223(92)90264-z.Peer-Reviewed Original Research
1989
Whole blood serotonin and tryptophan in autism: Temporal stability and the effects of medication
Minderaa R, Anderson G, Volkmar F, Harcherick D, Akkerhuis G, Cohen D. Whole blood serotonin and tryptophan in autism: Temporal stability and the effects of medication. Journal Of Autism And Developmental Disorders 1989, 19: 129-136. PMID: 2708296, DOI: 10.1007/bf02212724.Peer-Reviewed Original ResearchConceptsWhole blood serotoninPlatelet countMedicated groupBlood serotoninSex-matched normal controlsSignificant intraclass correlation coefficientsEffects of medicationWhole blood concentrationsAutistic groupIntraclass correlation coefficientMean percentage differenceBlood concentrationsNormal controlsNormal subjectsWhole bloodTRP valuesSerotoninTryptophan valuesYear periodGroupCountPercentage differenceMedicationsBlood
1987
WHOLE BLOOD SEROTONIN IN AUTISTIC AND NORMAL SUBJECTS
Anderson G, Freedman D, Cohen D, Volkmar F, Hoder E, McPhedran P, Minderaa R, Hansen C, Young J. WHOLE BLOOD SEROTONIN IN AUTISTIC AND NORMAL SUBJECTS. Journal Of Child Psychology And Psychiatry 1987, 28: 885-900. PMID: 3436995, DOI: 10.1111/j.1469-7610.1987.tb00677.x.Peer-Reviewed Original ResearchConceptsWhole blood serotoninSerotonin levelsBlood serotoninNormal subjectsWhole blood serotonin concentrationAutistic subjectsBlood serotonin concentrationsBlood tryptophan levelsLow serotonin levelsHyperserotonemia of autismPlatelet countSerotonin concentrationsNormal groupTryptophan levelsSerotoninAutistic groupSubjectsPossible causesAnticonvulsantsNeurolepticsGroupLevelsHyperserotonemiaUrinary 5-hydroxyindoleacetic acid and whole blood serotonin and tryptophan in autistic and normal subjects
Minderaa R, Anderson G, Volkmar F, Akkerhuis G, Cohen D. Urinary 5-hydroxyindoleacetic acid and whole blood serotonin and tryptophan in autistic and normal subjects. Biological Psychiatry 1987, 22: 933-940. PMID: 2440483, DOI: 10.1016/0006-3223(87)90002-3.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultAutistic DisorderFemaleHumansHydroxyindoleacetic AcidMaleSerotoninTryptophanSerotonin in cisternal cerebrospinal fluid of the rat: Measurement and use as an index of functionally active serotonin
Anderson G, Teff K, Young S. Serotonin in cisternal cerebrospinal fluid of the rat: Measurement and use as an index of functionally active serotonin. Life Sciences 1987, 40: 2253-2260. PMID: 2438530, DOI: 10.1016/0024-3205(87)90061-0.Peer-Reviewed Original Research
1986
Cerebrospinal fluid monoamine precursor and metabolite levels in children treated for leukemia: Age and sex effects and individual variability
Riddle M, Anderson G, McIntosh S, Harcherik D, Shaywitz B, Cohen D. Cerebrospinal fluid monoamine precursor and metabolite levels in children treated for leukemia: Age and sex effects and individual variability. Biological Psychiatry 1986, 21: 69-83. PMID: 2417634, DOI: 10.1016/0006-3223(86)90009-0.Peer-Reviewed Original ResearchConceptsAcute lymphoblastic leukemiaMetabolite homovanillic acidHomovanillic acidMonoamine precursorsCerebrospinal fluidLevels of HVALumbar cerebrospinal fluidCNS traumaCSF levelsLymphoblastic leukemiaMonoamine systemsCSF samplesChronic effectsSignificant sex differencesMetabolite levelsSignificant correlationLeukemiaSex differencesChildrenIndividual variabilityAgeSex effectsTreatmentLevelsMean coefficient
1985
NEUROTRANSMITTER PRECURSORS and METABOLITES IN CSF OF HUMAN NEONATES
Anderson G, Hoder E, Shaywitz B, Cohen D. NEUROTRANSMITTER PRECURSORS and METABOLITES IN CSF OF HUMAN NEONATES. Developmental Medicine & Child Neurology 1985, 27: 207-214. PMID: 2581835, DOI: 10.1111/j.1469-8749.1985.tb03771.x.Peer-Reviewed Original ResearchConceptsHuman neonatesAmino acid precursor tryptophanSignificant subgroup differencesMedical complicationsHomovanillic acidCerebrospinal fluidNeurotransmitter precursorsPrecursor tryptophanNeurotransmitter serotoninOlder childrenMajor metaboliteComplicated groupLatter groupComplicationsSignificant correlationNeonatesSubgroup differencesInfantsPhysiological measuresGroupMetabolitesLarge groupHigh levelsMedicationsNorepinephrineEffect of a Meal on Human Whole Blood Serotonin
Anderson G, Feibel F, Wetlaufer L, Schlicht K, Ort S, Cohen D. Effect of a Meal on Human Whole Blood Serotonin. Gastroenterology 1985, 88: 86-89. PMID: 2578039, DOI: 10.1016/s0016-5085(85)80137-2.Peer-Reviewed Original ResearchConceptsWhole blood serotoninMicrograms/hBlood serotoninGastrointestinal hormonesUrinary excretionSerotonin levelsBlood samplesUrine specimensBaseline levelsSerotoninSecond hourWhole bloodHuman subjectsSpecific high-performance liquid chromatographic methodMealMinSubjectsUrinaryLevelsExcretionBloodHormone
1984
Whole blood serotonin and tryptophan levels in Tourette's disorder: Effects of acute and chronic clonidine treatment
Leckman J, Anderson G, Cohen D, Ort S, Harcherik D, Hoder E, Shaywitz B. Whole blood serotonin and tryptophan levels in Tourette's disorder: Effects of acute and chronic clonidine treatment. Life Sciences 1984, 35: 2497-2503. PMID: 6595491, DOI: 10.1016/0024-3205(84)90435-1.Peer-Reviewed Original ResearchConceptsChronic clonidine treatmentClonidine treatmentTourette's disorder patientsWhole blood serotoninDisorder patientsTourette's disorderBlood serotoninTryptophan levelsMean differenceChronic treatmentAcute doseNormal controlsMean increaseClonidinePatientsDisordersMode of actionTreatmentSignificant differencesSerotoninBaseline conditionsLevelsDifferencesDose
1982
Determination of indoles in human and rat pineal
Anderson G, Young J, Cohen D, Young S. Determination of indoles in human and rat pineal. Journal Of Chromatography 1982, 228: 155-163. PMID: 6176588, DOI: 10.1016/s0378-4347(00)80428-4.Peer-Reviewed Original ResearchFactors Influencing Melatonin, 5-Hydroxytryptophol, 5-Hydroxyindoleacetic Acid, 5-Hydroxytryptamine and Tryptophan in Rat Pineal Glands
Young S, Anderson G. Factors Influencing Melatonin, 5-Hydroxytryptophol, 5-Hydroxyindoleacetic Acid, 5-Hydroxytryptamine and Tryptophan in Rat Pineal Glands. Neuroendocrinology 1982, 35: 464-468. PMID: 6185873, DOI: 10.1159/000123423.Peer-Reviewed Original ResearchDetermination of Neurochemically Important Compounds in Physiological Samples Using HPLC
Anderson G, Young J. Determination of Neurochemically Important Compounds in Physiological Samples Using HPLC. Schizophrenia Bulletin 1982, 8: 333-348. PMID: 6180473, DOI: 10.1093/schbul/8.2.333.Peer-Reviewed Original Research
1981
Applications of liquid chromatographic-fluorometric systems in neurochemistry
Anderson G, Young J. Applications of liquid chromatographic-fluorometric systems in neurochemistry. Life Sciences 1981, 28: 507-517. PMID: 7010039, DOI: 10.1016/0024-3205(81)90144-2.Peer-Reviewed Original Research
1980
The Origin of Indoleacetic Acid and Indolepropionic Acid in Rat and Human Cerebrospinal Fluid1
Young S, Anderson G, Gauthier S, Purdy W. The Origin of Indoleacetic Acid and Indolepropionic Acid in Rat and Human Cerebrospinal Fluid1. Journal Of Neurochemistry 1980, 34: 1087-1092. PMID: 6154772, DOI: 10.1111/j.1471-4159.1980.tb09944.x.Peer-Reviewed Original Research