1996
Inhibition of Epstein-Barr virus replication by a novel l-nucleoside, 2′-fluoro-5-methyl-β-l-arabinofuranosyluracil
Yao G, Liu S, Chou E, Kukhanova M, Chu C, Cheng Y. Inhibition of Epstein-Barr virus replication by a novel l-nucleoside, 2′-fluoro-5-methyl-β-l-arabinofuranosyluracil. Biochemical Pharmacology 1996, 51: 941-947. PMID: 8651944, DOI: 10.1016/0006-2952(96)00049-4.Peer-Reviewed Original ResearchMeSH KeywordsArabinofuranosyluracilAutoradiographyBase SequenceCells, CulturedDNAHerpesvirus 4, HumanHumansMolecular Sequence DataVirus ReplicationConceptsEpstein-Barr virus replicationL-FMAUNovel L-nucleoside analogVirus replicationEBV DNA polymeraseMechanism of actionL-nucleoside analoguesEBV agentsPotent inhibitory activityAntiviral activityEBVVirus productionInhibitory concentrationViral productionHuman DNA polymerase alphaSelective inhibitorViral DNAInhibitory activityMetabolism studiesCell growthCellsInhibitionDNA polymerase alphaCellular DNANon-producing cells
1995
Use of 2'-fluoro-5-methyl-beta-L-arabinofuranosyluracil as a novel antiviral agent for hepatitis B virus and Epstein-Barr virus
Chu C, Ma T, Shanmuganathan K, Wang C, Xiang Y, Pai S, Yao G, Sommadossi J, Cheng Y. Use of 2'-fluoro-5-methyl-beta-L-arabinofuranosyluracil as a novel antiviral agent for hepatitis B virus and Epstein-Barr virus. Antimicrobial Agents And Chemotherapy 1995, 39: 979-981. PMID: 7786007, PMCID: PMC162665, DOI: 10.1128/aac.39.4.979.Peer-Reviewed Original ResearchMeSH KeywordsAntiviral AgentsArabinofuranosyluracilCell DivisionDNA, MitochondrialHepatitis B virusHerpesvirus 4, HumanHumansTumor Cells, CulturedCharacterization of sublines of Epstein-Barr virus producing HR-1 cells and its implication in virus propagation in culture
Yao G, Tsai C, Cheng Y. Characterization of sublines of Epstein-Barr virus producing HR-1 cells and its implication in virus propagation in culture. Virus Genes 1995, 9: 247-255. PMID: 7597803, DOI: 10.1007/bf01702880.Peer-Reviewed Original ResearchConceptsH sublinesHR-1 cellsZEBRA proteinEBV-specific proteinsHigh EBV DNAEpstein-Barr virusDNA restriction enzyme fragmentsL sublinesEBV polymeraseEBV DNAEBV infectionEBV DNaseEBV proteinsZEBRA expressionEBV productionSodium butyrateSublinesReplication cycleEBVInfectionL cellsDilution methodMolecular characteristicsVirus propagationVirus
1993
Potent inhibition of Epstein-Barr virus by phosphorothioate oligodeoxynucleotides without sequence specification
Yao G, Grill S, Egan W, Cheng Y. Potent inhibition of Epstein-Barr virus by phosphorothioate oligodeoxynucleotides without sequence specification. Antimicrobial Agents And Chemotherapy 1993, 37: 1420-1425. PMID: 8395789, PMCID: PMC187987, DOI: 10.1128/aac.37.7.1420.Peer-Reviewed Original ResearchConceptsEpstein-Barr virusEpstein-Barr virus genesEBV DNA synthesisMechanism of actionEBV DNAEBV replicationS-oligoDrug exposureEBV agentsInhibitory doseViral DNA polymeraseVirus productionDosePotent inhibitionPhosphorothioate oligodeoxynucleotidePotent inhibitorInhibitionCell growthCell culturesDNA synthesisVirus genes