1996
A Double-blind, Placebo-Controlled Study of Fluvoxamine in Adults With Autistic Disorder
McDougle C, Naylor S, Cohen D, Volkmar F, Heninger G, Price L. A Double-blind, Placebo-Controlled Study of Fluvoxamine in Adults With Autistic Disorder. JAMA Psychiatry 1996, 53: 1001-1008. PMID: 8911223, DOI: 10.1001/archpsyc.1996.01830110037005.Peer-Reviewed Original ResearchConceptsStudy of FluvoxamineAutistic disorderSelective serotonin uptake inhibitorAdverse cardiovascular eventsPlacebo-controlled trialWeeks of treatmentSerotonin uptake inhibitorSerotonin neurotransmitter systemShort-term treatmentCardiovascular eventsPlacebo groupMild sedationNeurotransmitter systemsTreatment responseSafe drugUptake inhibitorFluvoxamineSymptoms of autismFluvoxamine maleateDisordersPlaceboAutistic behaviorPatientsAdultsSymptoms
1994
Lithium Augmentation of Fluvoxamine in Autistic Disorder: A Case Report
EPPERSON C, McDOUGLE C, ANAND A, MAREK G, NAYLOR S, VOLKMAR F, COHEN D, PRICE L. Lithium Augmentation of Fluvoxamine in Autistic Disorder: A Case Report. Journal Of Child And Adolescent Psychopharmacology 1994, 4: 201-207. DOI: 10.1089/cap.1994.4.201.Peer-Reviewed Original ResearchSerotonin uptake inhibitorLithium augmentationUptake inhibitorAutistic disorderMinimal clinical responseSubstantial clinical improvementWeeks of treatmentSingle case reportsSignificant adverse effectsClinical improvementClinical responseClinical evidenceCase reportSerotonin functionFluvoxamineMeaningful improvementsTreatment of autismPatientsMarked reductionRating ScaleAdverse effectsRelative efficacyDisordersWeeksTreatment