Fine balance between HIF1 and HIF2 in smooth muscle is crucial for normal development and survival
Lei L, Liu D, Jiang W, Huang Y, Giordano F. Fine balance between HIF1 and HIF2 in smooth muscle is crucial for normal development and survival. The FASEB Journal 2011, 25: 616.10-616.10. DOI: 10.1096/fasebj.25.1_supplement.616.10.Peer-Reviewed Original ResearchSmooth muscle cellsVon Hippel-LindauSmooth muscleDied of heart failureDeletion of von Hippel-LindauDouble knockoutVascular smooth muscle cellsMicro-CT angiographyNormal developmentEmbryonic lethalityApparent etiologyMidline defectsFetal developmentVascular reactivityEctopia cordisE14.5-15.5Heart failureMuscle cellsVascular spasmIntramyocardial hematomaVascular perfusionMiceGastroschisisVascular segmentsMicro-CT