2017
Compensatory Distal Reabsorption Drives Diuretic Resistance in Human Heart Failure
Rao VS, Planavsky N, Hanberg JS, Ahmad T, Brisco-Bacik MA, Wilson FP, Jacoby D, Chen M, Tang WHW, Cherney DZI, Ellison DH, Testani JM. Compensatory Distal Reabsorption Drives Diuretic Resistance in Human Heart Failure. Journal Of The American Society Of Nephrology 2017, 28: 3414-3424. PMID: 28739647, PMCID: PMC5661276, DOI: 10.1681/asn.2016111178.Peer-Reviewed Original ResearchMeSH KeywordsAgedDrug ResistanceFemaleHeart FailureHumansKidney Tubules, DistalMaleProspective StudiesRenal ReabsorptionSodium Potassium Chloride Symporter InhibitorsConceptsDiuretic resistanceHeart failureLoop diureticsSodium reabsorptionHigh-dose loop diureticsDistal tubular sodium reabsorptionSodium exitLoop diuretic administrationTubular sodium reabsorptionHuman heart failureFurosemide equivalentsDistal reabsorptionConsecutive patientsFractional excretionSodium handlingDiuretic administrationProximal tubularControl cohortCare centerTreatment strategiesAnimal modelsDiureticsNet sodiumFENaTubular location
2013
Cdc42 Deficiency Causes Ciliary Abnormalities and Cystic Kidneys
Choi SY, Chacon-Heszele MF, Huang L, McKenna S, Wilson FP, Zuo X, Lipschutz JH. Cdc42 Deficiency Causes Ciliary Abnormalities and Cystic Kidneys. Journal Of The American Society Of Nephrology 2013, 24: 1435-1450. PMID: 23766535, PMCID: PMC3752951, DOI: 10.1681/asn.2012121236.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsApoptosisCdc42 GTP-Binding ProteinCell ProliferationCiliaDisease Models, AnimalFibrosisIn Vitro TechniquesKidney Diseases, CysticKidney Tubules, CollectingKidney Tubules, DistalMiceMice, KnockoutMice, TransgenicMitogen-Activated Protein Kinase KinasesPhenotypeSignal TransductionVesicular Transport ProteinsZebrafishZebrafish ProteinsConceptsCiliary proteinsSynergistic genetic interactionMitogen-activated protein kinase activationSmall GTPase Cdc42Role of Cdc42Protein kinase activationKnockdown of Cdc42Trafficking complexGTPase Cdc42Genetic interactionsSec10 knockdownPolycystic kidney diseaseCyst cellsCdc42 knockdownPrimary ciliaPhotoreceptor ciliaCdc42Kinase activationExocystMAPK activationCiliogenesisSec10Same pathwayPathways resultsCdc42 deficiency