2020
Novel Risk Factors for Progression of Diabetic and Nondiabetic CKD: Findings From the Chronic Renal Insufficiency Cohort (CRIC) Study
Anderson AH, Xie D, Wang X, Baudier RL, Orlandi P, Appel LJ, Dember LM, He J, Kusek JW, Lash JP, Navaneethan SD, Ojo A, Rahman M, Roy J, Scialla JJ, Sondheimer JH, Steigerwalt SP, Wilson FP, Wolf M, Feldman HI, Investigators C, Go A, Townsend R. Novel Risk Factors for Progression of Diabetic and Nondiabetic CKD: Findings From the Chronic Renal Insufficiency Cohort (CRIC) Study. American Journal Of Kidney Diseases 2020, 77: 56-73.e1. PMID: 32866540, PMCID: PMC7752839, DOI: 10.1053/j.ajkd.2020.07.011.Peer-Reviewed Original ResearchConceptsChronic Renal Insufficiency Cohort (CRIC) StudyIndependent risk factorCKD progressionNovel risk factorsRisk factorsCohort studyComposite outcomeN-terminal pro-B-type natriuretic peptidePro-B-type natriuretic peptideChronic kidney disease progressionGlomerular filtration rate (eGFR) slopeHigh-sensitivity troponin TCox proportional hazards modelStudy designProgression of diabeticsUrinary neutrophil gelatinaseUrinary NGAL levelsUS clinical centersKidney disease progressionLow serum bicarbonateProspective cohort studyKidney replacement therapyHigh-risk subgroupsProportional hazards modelNumerous risk factors
2014
Plasma Lipoprotein(a) Levels Are Associated with Mild Renal Impairment in Type 2 Diabetics Independent of Albuminuria
Lin J, Reilly MP, Terembula K, Wilson FP. Plasma Lipoprotein(a) Levels Are Associated with Mild Renal Impairment in Type 2 Diabetics Independent of Albuminuria. PLOS ONE 2014, 9: e114397. PMID: 25490096, PMCID: PMC4260843, DOI: 10.1371/journal.pone.0114397.Peer-Reviewed Original ResearchConceptsPenn Diabetes Heart StudyGFR impairmentT2DM patientsRisk factorsModifiable CV risk factorsSingle-center observational cohortAtherogenic lipid profileCV risk factorsMild renal impairmentIndependent risk factorNormal renal functionWorse kidney functionType 2 diabeticsCKD-EPI equationDiabetes Heart StudyCross-sectional analysisLogistic regression modelsClinical CVDMild CKDCV diseaseRenal impairmentObservational cohortRenal functionCV preventionDiabetic counterparts