2012
Low Cefepime Concentrations during High Blood and Dialysate Flow Continuous Venovenous Hemodialysis
Wilson FP, Bachhuber MA, Caroff D, Adler R, Fish D, Berns J. Low Cefepime Concentrations during High Blood and Dialysate Flow Continuous Venovenous Hemodialysis. Antimicrobial Agents And Chemotherapy 2012, 56: 2178-2180. PMID: 22290968, PMCID: PMC3318326, DOI: 10.1128/aac.05987-11.Peer-Reviewed Original ResearchMeSH KeywordsAdultAnti-Bacterial AgentsCefepimeCephalosporinsChromatography, High Pressure LiquidFemaleHalf-LifeHemofiltrationHumansKidney Failure, ChronicKidney Tubular Necrosis, AcuteMaleMicrobial Sensitivity TestsMiddle AgedPseudomonas aeruginosaShock, CardiogenicSpectrophotometry, UltravioletYoung AdultConceptsContinuous venovenous hemodialysisCefepime concentrationsHigh blood flowTherapeutic concentrationsBlood flowHigher bloodHemodialysisPatientsPseudomonas aeruginosaCefepimeBloodDoseCreatinine generation is reduced in patients requiring continuous venovenous hemodialysis and independently predicts mortality
Wilson FP, Sheehan JM, Mariani LH, Berns JS. Creatinine generation is reduced in patients requiring continuous venovenous hemodialysis and independently predicts mortality. Nephrology Dialysis Transplantation 2012, 27: 4088-4094. PMID: 22273668, PMCID: PMC3529547, DOI: 10.1093/ndt/gfr809.Peer-Reviewed Original ResearchConceptsAcute kidney injuryCreatinine generation rateContinuous venovenous hemodialysisSeverity of AKISerum creatinine concentrationCreatinine concentrationHospital mortalityTertiary care hospital settingSerum creatinine increaseGlomerular filtration rateLength of hospitalizationMeasures of severityAKI severityCreatinine increaseKidney injuryHospital dischargeMultivariable adjustmentSerum creatinineCohort studyMultivariable analysisPatient populationUnadjusted analysesCreatinine generationFiltration rateOncologic diagnosis
2011
Vancomycin levels are frequently subtherapeutic during continuous venovenous hemodialysis (CVVHD)
Wilson FP, Berns JS. Vancomycin levels are frequently subtherapeutic during continuous venovenous hemodialysis (CVVHD). Clinical Nephrology 2011, 77: 329-331. PMID: 22445477, PMCID: PMC3359699, DOI: 10.5414/cn106993.Peer-Reviewed Original ResearchConceptsContinuous renal replacement therapyContinuous venovenous hemodialysisAcute kidney injuryRenal replacement therapyPopulation of patientsDialysis flow rateKidney injuryVancomycin levelsIntensive careReplacement therapyIntermittent dialysisSubtherapeutic levelsLow bloodNephrology traineesAntibioticsHemodialysisPatientsInjuryTherapyPopulationVancomycinBloodDialysisCare