2015
Gremlin 1 Identifies a Skeletal Stem Cell with Bone, Cartilage, and Reticular Stromal Potential
Worthley DL, Churchill M, Compton JT, Tailor Y, Rao M, Si Y, Levin D, Schwartz MG, Uygur A, Hayakawa Y, Gross S, Renz BW, Setlik W, Martinez AN, Chen X, Nizami S, Lee HG, Kang HP, Caldwell JM, Asfaha S, Westphalen CB, Graham T, Jin G, Nagar K, Wang H, Kheirbek MA, Kolhe A, Carpenter J, Glaire M, Nair A, Renders S, Manieri N, Muthupalani S, Fox JG, Reichert M, Giraud AS, Schwabe RF, Pradere JP, Walton K, Prakash A, Gumucio D, Rustgi AK, Stappenbeck TS, Friedman RA, Gershon MD, Sims P, Grikscheit T, Lee FY, Karsenty G, Mukherjee S, Wang TC. Gremlin 1 Identifies a Skeletal Stem Cell with Bone, Cartilage, and Reticular Stromal Potential. Cell 2015, 160: 269-284. PMID: 25594183, PMCID: PMC4436082, DOI: 10.1016/j.cell.2014.11.042.Peer-Reviewed Original ResearchConceptsBone morphogenetic proteinStem cellsMarrow stromal cellsMesenchymal stem cellsGremlin-1Skeletal stem cellsTissue stem cellsFate-mapping experimentsStromal cellsMorphogenetic proteinsPostnatal skeletonBone developmentCell of originMesenchymal sheathCellsAdipocytesOsteoblastsExpressionBone marrowChondrocytesProteinBone remodelingPerisinusoidal spaceRemodelingFracture repair
1994
Insulin-like Growth Factor I Regulation of Swarm Rat Chondrosarcoma Chondrocytes in Culture
Seong S, Matsumura T, Lee F, Whelan M, Li X, Trippel S. Insulin-like Growth Factor I Regulation of Swarm Rat Chondrosarcoma Chondrocytes in Culture. Experimental Cell Research 1994, 211: 238-244. PMID: 8143769, DOI: 10.1006/excr.1994.1083.Peer-Reviewed Original ResearchConceptsContribution of IGFDose-dependent fashionSwarm rat chondrosarcoma chondrocytesI antibodiesRat chondrosarcoma chondrocytesNonspecific antibodyFetal calf serumInsulin-like growth factor actionCalf serumInsulin-like growth factor IInsulin-like growth factor I regulationInhibitory effectChondrosarcoma chondrocytesRole of IGFIGF-I actionPresence of IGFEfficacy of IGFGrowth factor IMinimal inhibitory effectSerum-free controlsPost-natal lifeHalf-maximal stimulationEpiphyseal growth plateGrowth factor actionSerum concentrations