2024
Unique Spatial Transcriptomic Profiling of the Murine Femoral Fracture Callus: A Preliminary Report
Jiang W, Caruana D, Back J, Lee F. Unique Spatial Transcriptomic Profiling of the Murine Femoral Fracture Callus: A Preliminary Report. Cells 2024, 13: 522. PMID: 38534368, PMCID: PMC10969736, DOI: 10.3390/cells13060522.Peer-Reviewed Original ResearchConceptsMDA-MB-231Transcriptomic platformsGene expressionSpatially localized gene expressionMDA-MB-231 metastatic breast cancer cellsSpatial transcriptomics platformGenetic expression changesFracture healingMetastatic breast cancer cellsBreast cancer cellsImpaired fracture healingSingle-cell RNALocal gene expressionSpatial transcriptomic profilingFracture callus formationGenomic heterogeneitySequencing techniquesDisrupt bone homeostasisTranscriptome profilingIn situ hybridizationExpression changesSoft callusPathological fracturesWild-typeSpatial transcriptomics
2002
Repair of Bone Allograft Fracture Using Bone Morphogenetic Protein-2
Lee FY, Storer S, Hazan EJ, Gebhardt MC, Mankin HJ. Repair of Bone Allograft Fracture Using Bone Morphogenetic Protein-2. Clinical Orthopaedics And Related Research® 2002, 397: 119-126. PMID: 11953604, DOI: 10.1097/00003086-200204000-00017.Peer-Reviewed Original ResearchConceptsAllograft fractureNormal fracture healingFracture healingProtein 2Long-term clinical dataExtensive tumour surgeryBone morphogenetic protein-2Major revision surgeryMorphogenetic protein-2Experimental groupOnly fibrosisRadiographic unionNew bone formationRevision surgeryAdditional ratsClinical dataTumor surgeryBone allograftAllograft boneControl groupBiologic regulatorsOsteotomy siteFracture repairRecombinant human bone morphogenetic protein-2Adequate function
1997
Regional and temporal changes in the acoustic properties of fracture callus in secondary bone healing
Harten R, Lee F, Zimmerman M, Hurowitz E, Arakal R, Behrens F. Regional and temporal changes in the acoustic properties of fracture callus in secondary bone healing. Journal Of Orthopaedic Research® 1997, 15: 570-576. PMID: 9379267, DOI: 10.1002/jor.1100150413.Peer-Reviewed Original ResearchConceptsScanning acoustic microscopeMechanical propertiesAcoustic microscopyAcoustic microscopeMaterial propertiesAcoustic impedance mapsConventional testing methodsAcoustic propertiesImpedanceSecondary bone healingImpedance mapsTesting methodsPropertiesAccurate determinationBone healingPopular choiceFracturesLinear relationshipFracture healingDevicesPolymethylmethacrylateMicroscopeMean impedanceMaterials