2018
Bradykinin B2 Receptor Contributes to Inflammatory Responses in Human Endothelial Cells by the Transactivation of the Fibroblast Growth Factor Receptor FGFR-1
Terzuoli E, Corti F, Nannelli G, Giachetti A, Donnini S, Ziche M. Bradykinin B2 Receptor Contributes to Inflammatory Responses in Human Endothelial Cells by the Transactivation of the Fibroblast Growth Factor Receptor FGFR-1. International Journal Of Molecular Sciences 2018, 19: 2638. PMID: 30200598, PMCID: PMC6163484, DOI: 10.3390/ijms19092638.Peer-Reviewed Original ResearchMeSH KeywordsBradykininCell MovementCells, CulturedEndothelial CellsFibroblast Growth Factor 2Human Umbilical Vein Endothelial CellsHumansPhosphorylationReceptor, Bradykinin B2Receptor, Fibroblast Growth Factor, Type 1Signal TransductionTight JunctionsConceptsFibroblast growth factor receptor 1Human umbilical vein endothelial cellsCell permeabilityEndothelial cellsFGFR-1 phosphorylationEndothelial cell permeabilityFGF-2 signalingFGF-2 pathwaysFGF-2/FGFRFGFR-1 inhibitorsC-SrcGrowth factor receptor 1Umbilical vein endothelial cellsDownstream signalingHuman endothelial cellsGrowth factor 2Vein endothelial cellsFactor receptor 1Cell migrationFGF-2 upregulationAmplification loopSignalingFactor 2Angiogenic disordersBradykinin B2 receptor
2008
Dutch and arctic mutant peptides of β amyloid1–40 differentially affect the FGF-2 pathway in brain endothelium
Solito R, Corti F, Fossati S, Mezhericher E, Donnini S, Ghiso J, Giachetti A, Rostagno A, Ziche M. Dutch and arctic mutant peptides of β amyloid1–40 differentially affect the FGF-2 pathway in brain endothelium. Experimental Cell Research 2008, 315: 385-395. PMID: 19061884, PMCID: PMC2764262, DOI: 10.1016/j.yexcr.2008.11.002.Peer-Reviewed Original ResearchMeSH KeywordsAmyloid beta-PeptidesApoptosisBrainCells, CulturedEndothelial CellsEndothelium, VascularFibroblast Growth Factor 2HumansMicrovesselsMutationPeptide FragmentsReceptor, Fibroblast Growth Factor, Type 1Signal TransductionConceptsAnti-angiogenic profileDegree of tropismCerebral amyloid angiopathyFGF-2 expressionFGF-2 receptorFibroblast growth factorEndothelial cell proliferationMicrovessel remodelingAmyloid angiopathyBrain endotheliumΒ-amyloid1Brain vesselsInduction of apoptosisAbeta variantsCerebral ECsFGF-2 pathwaysG variantE22GGrowth factorWT peptideFGFR-1Cell proliferationFGF-2Hereditary phenotypesDifferential effects