2017
Oxidative stress and inflammation as central mediators of atrial fibrillation in obesity and diabetes
Karam BS, Chavez-Moreno A, Koh W, Akar JG, Akar FG. Oxidative stress and inflammation as central mediators of atrial fibrillation in obesity and diabetes. Cardiovascular Diabetology 2017, 16: 120. PMID: 28962617, PMCID: PMC5622555, DOI: 10.1186/s12933-017-0604-9.Peer-Reviewed Original ResearchConceptsAtrial fibrillationOxidative stressCommon sustained cardiac arrhythmiaMaintenance of AFSustained cardiac arrhythmiaDiabetic heartElectrical remodelingRisk factorsAtrial excitabilityTherapeutic strategiesCardiac arrhythmiasInflammationCentral mediatorObesityDiabetesFibrillationMechanistic linkMellitusArrhythmiasExcitability
2004
Ionic mechanisms of cardiac arrhythmias
Akar F, Tomaselli G. Ionic mechanisms of cardiac arrhythmias. Drug Discovery Today Disease Mechanisms 2004, 1: 23-30. DOI: 10.1016/j.ddmec.2004.08.005.ChaptersIndividual cardiac myocytesArrhythmia controlCardiac arrhythmiasIntricate vascular networkDuke University Medical CenterCardiac myocytesGood arrhythmia controlSudden cardiac death casesCardiac death casesUniversity Medical CenterIonic mechanismsGenetic risk factorsPascal J. Goldschmidt-ClermontGlobal electrical activityCardiovascular deathAbnormal heart rhythmMalignant arrhythmiasDrug therapyRhythm disturbancesHeart diseaseRisk factorsMedical CenterTherapeutic strategiesArrhythmia syndromesCardiac chambers