2023
Alterations in microRNA of extracellular vesicles associated with major depression, attention-deficit/hyperactivity and anxiety disorders in adolescents
Honorato-Mauer J, Xavier G, Ota V, Chehimi S, Mafra F, Cuóco C, Ito L, Ormond R, Asprino P, Oliveira A, Bugiga A, Torrecilhas A, Bressan R, Manfro G, Miguel E, Rohde L, Pan P, Salum G, Pellegrino R, Belangero S, Santoro M. Alterations in microRNA of extracellular vesicles associated with major depression, attention-deficit/hyperactivity and anxiety disorders in adolescents. Translational Psychiatry 2023, 13: 47. PMID: 36746925, PMCID: PMC9902559, DOI: 10.1038/s41398-023-02326-4.Peer-Reviewed Original ResearchConceptsMental health disordersCross-sectional analysisMajor depressive disorderAttention-deficit/hyperactivity disorderHealth disordersAnxiety disordersExtracellular vesiclesLarge ongoing cohort studiesMiR-432-5pPeripheral extracellular vesiclesTime pointsOngoing cohort studyMiR-328-3pSerum extracellular vesiclesLongitudinal analysisWave 2Deficit/hyperactivity disorderAdolescent participantsTotal extracellular vesiclesAttention-deficit/hyperactivityMiRNA expressionCohort studyDepressive disorderMajor depressionMiR-584-5p
2022
Obsessional slowness in obsessive-compulsive disorder: identifying characteristics and comorbidities in a clinical sample
Crowe E, Rosário M, Ferrão Y, Albertella L, Miguel E, Fontenelle L. Obsessional slowness in obsessive-compulsive disorder: identifying characteristics and comorbidities in a clinical sample. International Journal Of Psychiatry In Clinical Practice 2022, 27: 161-170. PMID: 36409661, DOI: 10.1080/13651501.2022.2147441.Peer-Reviewed Original ResearchDeviations from a typical development of the cerebellum in youth are associated with psychopathology, executive functions and educational outcomes
Borges M, Hoffmann M, Simioni A, Axelrud L, Teixeira D, Zugman A, Jackowski A, Pan P, Bressan R, Parker N, Germann J, Bado P, Satterthwaite T, Milham M, Chakravarty M, Rohde L, Miguel E, Paus T, Salum G. Deviations from a typical development of the cerebellum in youth are associated with psychopathology, executive functions and educational outcomes. Psychological Medicine 2022, 53: 5698-5708. PMID: 36226568, DOI: 10.1017/s0033291722002926.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentCerebellumChildCohort StudiesCross-Sectional StudiesExecutive FunctionHumansMental DisordersConceptsExecutive functionTypical developmentInhibitory controlAcademic achievementCerebellar volumeHigher executive functionChild Behavior ChecklistTypical brain developmentSchool achievementBehavior ChecklistMental health conditionsStandardized measuresMediation analysisMental healthHigh Risk Cohort StudyEducational outcomesPsychopathologyBrain developmentMental conditionLongitudinal analysisYouthSpecific factorsAchievementCognitionAdolescenceAssociations of medication with subcortical morphology across the lifespan in OCD: Results from the international ENIGMA Consortium
Ivanov I, Boedhoe PSW, Abe Y, Alonso P, Ameis SH, Arnold PD, Balachander S, Baker JT, Banaj N, Bargalló N, Batistuzzo MC, Benedetti F, Beucke JC, Bollettini I, Brem S, Brennan BP, Buitelaar J, Calvo R, Cheng Y, Cho KIK, Dallaspezia S, Denys D, Diniz JB, Ely BA, Feusner JD, Ferreira S, Fitzgerald KD, Fontaine M, Gruner P, Hanna GL, Hirano Y, Hoexter MQ, Huyser C, Ikari K, James A, Jaspers-Fayer F, Jiang H, Kathmann N, Kaufmann C, Kim M, Koch K, Kwon JS, Lázaro L, Liu Y, Lochner C, Marsh R, Martínez-Zalacaín I, Mataix-Cols D, Menchón JM, Minuzzi L, Morer A, Morgado P, Nakagawa A, Nakamae T, Nakao T, Narayanaswamy JC, Nurmi EL, Oh S, Perriello C, Piacentini JC, Picó-Pérez M, Piras F, Piras F, Reddy YCJ, Manrique DR, Sakai Y, Shimizu E, Simpson HB, Soreni N, Soriano-Mas C, Spalletta G, Stern ER, Stevens MC, Stewart SE, Szeszko PR, Tolin DF, van Rooij D, Veltman DJ, van der Werf YD, van Wingen GA, Venkatasubramanian G, Walitza S, Wang Z, Watanabe A, Wolters LH, Xu X, Yun JY, Zarei M, Zhang F, Zhao Q, Jahanshad N, Thomopoulos SI, Thompson PM, Stein DJ, van den Heuvel OA, O'Neill J, Group T, Poletti S, Fridgeirsson E, Ikuta T, de Wit S, Vriend C, Kasprzak S, Kuno M, Takahashi J, Miguel E, Shavitt R, Hough M, Pariente J, Ortiz A, Bertolín S, Real E, Segalàs C, Moreira P, Sousa N, Narumoto J, Yamada K, Tang J, Fouche J, Kim T, Choi S, Ha M, Park S. Associations of medication with subcortical morphology across the lifespan in OCD: Results from the international ENIGMA Consortium. Journal Of Affective Disorders 2022, 318: 204-216. PMID: 36041582, DOI: 10.1016/j.jad.2022.08.084.Peer-Reviewed Original ResearchConceptsObsessive-compulsive disorderUnmedicated patientsOlder adultsAssociation of medicationVolumes of putamenSubcortical brain structuresReuptake inhibitorsVentricular hypertrophyHippocampal atrophyMedicated patientsPsychotropic medicationsTherapeutic responseHippocampal volumeStriatal volumeSubcortical nucleiPatientsPsychotic disordersAntipsychoticsSubcortical morphologyStructural MRINormal agingBrain structuresBenzodiazepinesOCD patientsENIGMA consortiumThreat and deprivation are associated with distinct aspects of cognition, emotional processing, and psychopathology in children and adolescents
Schäfer J, McLaughlin K, Manfro G, Pan P, Rohde L, Miguel E, Simioni A, Hoffmann M, Salum G. Threat and deprivation are associated with distinct aspects of cognition, emotional processing, and psychopathology in children and adolescents. Developmental Science 2022, 26: e13267. PMID: 35417607, PMCID: PMC10028496, DOI: 10.1111/desc.13267.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentChildChild DevelopmentCognitionCross-Sectional StudiesEmotionsExecutive FunctionHumansConceptsChild Behavior ChecklistExecutive functionEmotional processingChildhood adversityBrazilian High-Risk CohortForms of adversityPoor developmental outcomesAttention biasAngry facesCognitive tasksCognitive developmentDevelopmental correlatesBehavior ChecklistChild developmentDevelopmental outcomesLongitudinal associationsGeneral psychopathologyPsychopathologyAdversityLatent constructsDifferential associationsWorse performanceDistinct aspectsCognitionMeaningful influenceLatency to treatment seeking in patients with obsessive-compulsive disorder: Results from a large multicenter clinical sample
Costa D, de Campos A, Pereira C, Torres A, Dos Santos A, Requena G, Ferrão Y, do Rosário M, Miguel E, Simpson H, Shavitt R, Diniz J. Latency to treatment seeking in patients with obsessive-compulsive disorder: Results from a large multicenter clinical sample. Psychiatry Research 2022, 312: 114567. PMID: 35490573, DOI: 10.1016/j.psychres.2022.114567.Peer-Reviewed Original ResearchConceptsObsessive-compulsive disorderEarly onsetOne-thirdCross-sectional studyInterval-censored survival modelClinical characteristicsOlder patientsSymptom awarenessPatientsNeuropsychiatric disordersSymptomsOlder ageOCD patientsContamination/Clinical samplesDisordersAggression symptomsOCD symptomsMore yearsTreatmentSurvival modelsOnsetYearsFull-time employmentComorbiditiesFactor structure of the Dimensional Yale-Brown Obsessive-Compulsive Scale in a large sample of adults with obsessive-compulsive disorder
Batistuzzo M, Fontenelle L, Ferrão Y, Rosário M, Miguel E, Fatori D. Factor structure of the Dimensional Yale-Brown Obsessive-Compulsive Scale in a large sample of adults with obsessive-compulsive disorder. Brazilian Journal Of Psychiatry 2022, 44: 57-60. PMID: 34878003, PMCID: PMC8827375, DOI: 10.1590/1516-4446-2021-2088.Peer-Reviewed Original Research
2021
How do daily routines and situational factors affect the severity of obsessive-compulsive disorder?
Brierley M, Albertella L, do Rosário M, Ferrão Y, Miguel E, Fontenelle L. How do daily routines and situational factors affect the severity of obsessive-compulsive disorder? Journal Of Psychiatric Research 2021, 143: 395-399. PMID: 34600268, DOI: 10.1016/j.jpsychires.2021.09.040.Peer-Reviewed Original ResearchConceptsObsessive-compulsive disorderOCD symptom severitySymptom severityOCD symptomsOCD patientsSevere OCD symptomsYale-Brown ObsessiveCross-sectional designReport symptomsHistory questionnaireCommon biological abnormalitiesBiological abnormalitiesClinical implicationsSymptomsDaily routineCompulsive ScaleSeverityMultivariate regressionPatientsRoutine factorsDisordersMental Health Impact in Latin American Pediatric Rheumatologists During the COVID-19 Pandemic
Kozu K, Casella C, Strabelli C, Aikawa N, Campos L, Elias A, Miguel E, Polanczyk G, Silva C. Mental Health Impact in Latin American Pediatric Rheumatologists During the COVID-19 Pandemic. JCR Journal Of Clinical Rheumatology 2021, 28: e506-e510. PMID: 34371514, DOI: 10.1097/rhu.0000000000001782.Peer-Reviewed Original ResearchMeSH KeywordsAdultAgedAnxietyChildCOVID-19Cross-Sectional StudiesDepressionHealth PersonnelHumansLatin AmericaMental HealthMiddle AgedPandemicsRheumatologistsSARS-CoV-2ConceptsVisual analog scaleMental health impactVAS scoresPediatric rheumatologistsMental healthChildhood-onset systemic lupus erythematosusCOVID-19 pandemicPrevious mental health disordersMedian current ageIdiopathic arthritis patientsSystemic lupus erythematosusHealth promotion strategiesCross-sectional studyGAD-7 scoresMental health disordersCOVID-19Health impactsCOVID-19 frontlineArthritis patientsLupus erythematosusAnalog scaleSleep abnormalitiesSevere depressionHealth disordersResponse rateDisability in children and adolescents: the extent of the impact on psychiatric disorders and educational deficits.
Zaqueu L, Teixeira M, Lowenthal R, Mari J, Miguel E, Rohde L, Paula C. Disability in children and adolescents: the extent of the impact on psychiatric disorders and educational deficits. Trends In Psychiatry And Psychotherapy 2021, 43: 235-239. PMID: 34860479, PMCID: PMC8638709, DOI: 10.47626/2237-6089-2020-0059.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAttention Deficit Disorder with HyperactivityChildCross-Sectional StudiesDisabled PersonsEducational StatusHumansMotor DisordersConceptsAttention deficit hyperactivity disorderChildren/adolescentsAcademic performanceTypical developmentSchool failureType of disabilityPsychiatric disordersDeficit hyperactivity disorderEducational deficitsPoor academic performanceWorse academic performanceBrazilian children/adolescentsPresence of disabilityMental health problemsSchool-aged childrenMiddle-income countriesHyperactivity disorderSixth gradersMulticenter cross-sectional studyAdolescentsTen Questions QuestionnaireCross-sectional studyIntellectual disabilityLogistic regression modelsSpecific interventions
2020
Predicting marriage and divorce in obsessive-compulsive disorder
Muhlbauer J, Ferrão Y, Eppingstall J, Albertella L, do Rosário M, Miguel E, Fontenelle L. Predicting marriage and divorce in obsessive-compulsive disorder. Journal Of Sex & Marital Therapy 2020, 47: 90-98. PMID: 32783604, DOI: 10.1080/0092623x.2020.1804021.Peer-Reviewed Original ResearchMeSH KeywordsAdultBrazilCross-Sectional StudiesFemaleHumansMaleMarital StatusMiddle AgedObsessive-Compulsive DisorderConceptsObsessive-compulsive disorder
2019
Genetic risk for Alzheimer's disease and functional brain connectivity in children and adolescents
Axelrud L, Sato J, Santoro M, Talarico F, Pine D, Rohde L, Zugman A, Junior E, Bressan R, Grassi-Oliveira R, Pan P, Hoffmann M, Simioni A, Guinjoan S, Hakonarson H, Brietzke E, Gadelha A, Pellegrino da Silva R, Hoexter M, Miguel E, Belangero S, Salum G. Genetic risk for Alzheimer's disease and functional brain connectivity in children and adolescents. Neurobiology Of Aging 2019, 82: 10-17. PMID: 31376729, PMCID: PMC7658444, DOI: 10.1016/j.neurobiolaging.2019.06.011.Peer-Reviewed Original ResearchConceptsAlzheimer's diseaseAD-PRSBrain connectivityGenetic riskRight superior temporal gyrusFunctional brain connectivityMagnetic resonance imagingInhibitory controlSuperior temporal gyrusTau pathologyAD developmentPolygenic risk scoresRisk scoreRight precuneusResonance imagingTau proteinTemporal gyrusDiseaseBrain connectionsEarly lifePathology networkFunctional networksRiskPorto AlegreMemory performanceThe impact of attention deficit hyperactivity disorder in obsessive‐compulsive disorder subjects
Blanco‐Vieira T, Santos M, Ferrão YA, Torres AR, Miguel EC, Bloch MH, Leckman JF, do Rosario MC. The impact of attention deficit hyperactivity disorder in obsessive‐compulsive disorder subjects. Depression And Anxiety 2019, 36: 533-542. PMID: 30990937, DOI: 10.1002/da.22898.Peer-Reviewed Original ResearchConceptsAttention deficit hyperactivity disorderAdult OCD patientsObsessive-compulsive disorderDeficit hyperactivity disorderOCD patientsClinical characteristicsExact testFeatures of ADHDHyperactivity disorderSubgroup of patientsAdult obsessive-compulsive disorderComorbid attention deficit hyperactivity disorderSpecific clinical featuresCross-sectional studyObsessive-compulsive disorder (OCD) subjectsLogistic regression analysisFisher's exact testBrazilian Research ConsortiumMann-Whitney testAdult patientsRheumatic feverDevelopment of interventionsClinical featuresObsessive-compulsive spectrum disordersLifetime prevalence
2018
Effect of male-specific childhood trauma on telomere length
Xavier G, Spindola L, Ota V, Carvalho C, Maurya P, Tempaku P, Moretti P, Mazotti D, Sato J, Brietzke E, Miguel E, Grassi-Oliveira R, Mari J, Bressan R, Gadelha A, Pan P, Belangero S. Effect of male-specific childhood trauma on telomere length. Journal Of Psychiatric Research 2018, 107: 104-109. PMID: 30384090, DOI: 10.1016/j.jpsychires.2018.10.012.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentBehavioral SymptomsBrazilChildChild AbuseCross-Sectional StudiesFemaleHumansMaleSex FactorsTelomereTelomere ShorteningConceptsHigh-risk cohortTelomere lengthImportant risk factorCross-sectional studyChild maltreatmentEarly life stressChild Behavior Checklist scoresSchool-based studySerious lifelong consequencesQuantitative polymerase chain reactionHistory of CMPolymerase chain reactionRisk factorsPsychiatric symptomsPsychiatric disordersMultiplex quantitative polymerase chain reactionLifelong consequencesBlood cellsChildhood traumaCM scoreLife stressChain reactionSexBrazilian High-Risk CohortShort telomeresCross-Sectional and Longitudinal Associations of Temperament and Mental Disorders in Youth
Hoffmann M, Pan P, Manfro G, de Jesus Mari J, Miguel E, Bressan R, Rohde L, Salum G. Cross-Sectional and Longitudinal Associations of Temperament and Mental Disorders in Youth. Child Psychiatry & Human Development 2018, 50: 374-383. PMID: 30259212, DOI: 10.1007/s10578-018-0846-0.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdolescent BehaviorCross-Sectional StudiesFemaleHumansLongitudinal StudiesMaleNeurodevelopmental DisordersPersonality AssessmentPsychopathologyTemperamentConceptsAttention-deficit/hyperactivity disorderDisruptive behavior disordersEffortful controlLongitudinal associationsMental disordersWell-Being Behavior AssessmentEffects of temperamentConfirmatory factor analysisTemperament factorsHyperactivity disorderBifactor modelTemperament QuestionnaireAdjusted longitudinal analysesTemperamentBehavior disorderDistressFactor analysisParental interviewsPhobiaBehavior assessmentLongitudinal analysisYouthDisordersLogistic regression modelsEATQPrevalência de problemas de saúde mental na infância na atenção primária
Fatori D, Brentani A, Grisi S, Miguel E, Graeff-Martins A. Prevalência de problemas de saúde mental na infância na atenção primária. Ciência & Saúde Coletiva 2018, 23: 3013-3020. PMID: 30281738, DOI: 10.1590/1413-81232018239.25332016.Peer-Reviewed Original ResearchConceptsMental health problemsPrimary healthcare unitsHealth professionalsHealth problemsPrimary care settingHealth service usePrevalence of internalizingPublic health problemPresent population studyMental health professionalsMedication treatmentYear old childrenHigh prevalenceCare settingsAtenção primáriaService useHealth servicesSample of childrenOlder childrenPrevalenceTreatment constituteDifficulties QuestionnairePopulation studiesHealthcare unitsChildrenSocioeconomic diversities and infant development at 6 to 9 months in a poverty area of São Paulo, Brazil
Tella P, da Rosa Piccolo L, Rangel M, Rohde L, Polanczyk G, Miguel E, Grisi S, Fleitlich-Bilyk B, Ferraro A. Socioeconomic diversities and infant development at 6 to 9 months in a poverty area of São Paulo, Brazil. Trends In Psychiatry And Psychotherapy 2018, 40: 232-240. PMID: 30156646, DOI: 10.1590/2237-6089-2017-0008.Peer-Reviewed Original ResearchMeSH KeywordsBrazilChild DevelopmentCitiesCognitionCross-Sectional StudiesFemaleHumansInfantLanguageMaleMotor SkillsPoverty AreasRisk FactorsSurveys and QuestionnairesConceptsCognitive developmentInfant developmentInfant languageInfants' performanceMaternal educationCognitive scoresMotor skillsSocioeconomic statusIntervention effortsBayley ScalesHigh languageSES effectsParticipant familiesEarly childhoodMotor ScaleLanguageSocioeconomic backgroundHigher maternal educationPositive associationChildhoodSocioeconomic diversityInfancySkillsFirst yearChildrenEarly vulnerabilities for psychiatric disorders in elementary schoolchildren from four Brazilian regions
Paula C, Mari J, Bordin I, Miguel E, Fortes I, Barroso N, Rohde L, Coutinho E. Early vulnerabilities for psychiatric disorders in elementary schoolchildren from four Brazilian regions. Social Psychiatry And Psychiatric Epidemiology 2018, 53: 477-486. PMID: 29511791, DOI: 10.1007/s00127-018-1503-4.Peer-Reviewed Original Research
2016
Socioeconomic Disadvantage Moderates the Association between Peripheral Biomarkers and Childhood Psychopathology
Mansur R, Cunha G, Asevedo E, Zugman A, Zeni-Graiff M, Rios A, Sethi S, Maurya P, Levandowski M, Gadelha A, Pan P, Stertz L, Belangero S, Anna M, Teixeira A, Mari J, Rohde L, Miguel E, McIntyre R, Grassi-Oliveira R, Bressan R, Brietzke E. Socioeconomic Disadvantage Moderates the Association between Peripheral Biomarkers and Childhood Psychopathology. PLOS ONE 2016, 11: e0160455. PMID: 27489945, PMCID: PMC4973983, DOI: 10.1371/journal.pone.0160455.Peer-Reviewed Original ResearchConceptsBrain-derived neurotrophic factorThiobarbituric acid reactive substancesMental health problemsInterleukin-6Serum levelsHealth problemsSocioeconomic disadvantagePeripheral biomarkersSerum biomarkersOxidative stress markersAcid reactive substancesCross-sectional designChild Behavior Checklist DSMNeurotrophic factorHigher socioeconomic disadvantageSocio-demographic characteristicsBiomarker levelsNeurotrophic proteinsDomains of psychopathologyStress markersSpecific SubscaleCumulative risk modelBiomarkersMultiple biological systemsPathological neurodevelopmentCoordinated brain development: exploring the synchrony between changes in grey and white matter during childhood maturation
Moura L, Crossley N, Zugman A, Pan P, Gadelha A, Del Aquilla M, Picon F, Anés M, Amaro E, de Jesus Mari J, Miguel E, Rohde L, Bressan R, McGuire P, Sato J, Jackowski A. Coordinated brain development: exploring the synchrony between changes in grey and white matter during childhood maturation. Brain Imaging And Behavior 2016, 11: 808-817. PMID: 27169540, DOI: 10.1007/s11682-016-9555-0.Peer-Reviewed Original ResearchConceptsMagnetic resonance imagingCortical thicknessDiffusion tensor imagingFractional anisotropyWhite matterBrain regionsStructural magnetic resonance imagingGray matter changesWhite matter tractsGray matter regionsCortical thinningMatter changesResonance imagingBrain developmentMatter regionsTensor imagingRespective tractsSignificant heterogeneityTractPrefrontal regionsAge 7Previous studiesBrain architectureAsynchronous maturation