2017
Randomized, Double-Blind, Placebo-Controlled Trial of N-Acetylcysteine Augmentation for Treatment-Resistant Obsessive-Compulsive Disorder.
Costa DLC, Diniz JB, Requena G, Joaquim MA, Pittenger C, Bloch MH, Miguel EC, Shavitt RG. Randomized, Double-Blind, Placebo-Controlled Trial of N-Acetylcysteine Augmentation for Treatment-Resistant Obsessive-Compulsive Disorder. The Journal Of Clinical Psychiatry 2017, 78: e766-e773. PMID: 28617566, DOI: 10.4088/jcp.16m11101.Peer-Reviewed Original ResearchMeSH KeywordsAcetylcysteineAdolescentAdultAgedAnxiety DisordersComorbidityDepressive DisorderDouble-Blind MethodDrug ResistanceDrug Therapy, CombinationFemaleHumansMaleMiddle AgedObsessive-Compulsive DisorderPsychiatric Status Rating ScalesPsychometricsSelective Serotonin Reuptake InhibitorsYoung AdultConceptsTreatment-resistant obsessive-compulsive disorderObsessive-compulsive disorderY-BOCS scoresN-acetylcysteineNAC groupYale-Brown Obsessive Compulsive Scale scoresTreatment-resistant OCD patientsBaseline Y-BOCS scoresTreatment-Resistant ObsessivePrimary outcome measureAnxiety symptomsDSM-IV criteriaSymptom dimensionsCompulsive Scale scoresSpecific OCD symptom dimensionsOCD symptom dimensionsAntioxidant medicationsAbdominal painPlacebo groupGlutamate modulatorsSecondary outcomesTertiary hospitalOutpatient clinicSeverity scoreWeek 16
2015
Reduced Prefrontal Activation in Pediatric Patients With Obsessive-Compulsive Disorder During Verbal Episodic Memory Encoding
Batistuzzo M, Balardin J, da Graça Morais Martin M, Hoexter M, Bernardes E, Borcato S, de Marco e Souza M, Querido C, Morais R, de Alvarenga P, Lopes A, Shavitt R, Savage C, Amaro E, Miguel E, Polanczyk G, Miotto E. Reduced Prefrontal Activation in Pediatric Patients With Obsessive-Compulsive Disorder During Verbal Episodic Memory Encoding. Journal Of The American Academy Of Child & Adolescent Psychiatry 2015, 54: 849-858. PMID: 26407495, DOI: 10.1016/j.jaac.2015.06.020.Peer-Reviewed Original ResearchConceptsVerbal episodic memoryObsessive-compulsive disorderEpisodic memoryOrbitofrontal cortexPrefrontal cortexSemantic clusteringFunctional magnetic resonance imagingDorsomedial prefrontal cortexAltered brain activationDifferent neural mechanismsPathophysiology of OCDUnrelated wordsPrefrontal activationBrain activationWord listsExecutive dysfunctionNeural mechanismsTotal wordsCompulsive Scale scoresYale-Brown Obsessive Compulsive Scale scoresStrategy scoresStrategy applicationMemoryCortexKey regions