Initial findings of striatum tripartite model in OCD brain samples based on transcriptome analysis
Lisboa B, Oliveira K, Tahira A, Barbosa A, Feltrin A, Gouveia G, Lima L, Feio dos Santos A, Martins D, Puga R, Moretto A, De Bragança Pereira C, Lafer B, Leite R, Ferretti-Rebustini R, Farfel J, Grinberg L, Jacob-Filho W, Miguel E, Hoexter M, Brentani H. Initial findings of striatum tripartite model in OCD brain samples based on transcriptome analysis. Scientific Reports 2019, 9: 3086. PMID: 30816141, PMCID: PMC6395771, DOI: 10.1038/s41598-019-38965-1.Peer-Reviewed Original ResearchConceptsObsessive-compulsive disorderSynaptic transmissionPathophysiology of OCDDifferent striatal subregionsPostmortem brain tissueChemical synaptic transmissionStriatal areasCortico-striatoNeurotransmitter levelsStriatum regionThalamic circuitryStriatal subregionsSubregion specificityPsychiatric disordersPresynaptic processesSynaptic plasticityBrain samplesOCD pathophysiologyBrain tissueCSTC modelControl casesPathophysiologyRare variantsDisordersCellular responsesSU72 TRANSCRIPTOME STUDY IN OBSESSIVE COMPULSIVE DISORDERS
Lisboa B, Tahira A, Sant'Anna A, Oliveira K, Miguel E, Hoexter M, Farfel J, Brentani H. SU72 TRANSCRIPTOME STUDY IN OBSESSIVE COMPULSIVE DISORDERS. European Neuropsychopharmacology 2019, 29: s927. DOI: 10.1016/j.euroneuro.2017.08.261.Peer-Reviewed Original ResearchObsessive-compulsive disorderNucleus accumbensSubgenual cingulate gyrusCortico-striatal circuitryOrbitofrontal cortexAffective circuitryCingulate gyrusCaudate nucleusBrain areasCognitive circuitryBrazilian Aging Brain Study GroupCompulsive disorderEnsheathment of neuronsEnrichment analysisBackground Obsessive-compulsive disorderDrug metabolic processFunctional neuroimaging studiesCortico-striatal loopsDopaminergic synapsesBrain BankThalamic circuitryGene expressionStudy groupNeurological system processPsychiatric disorders