2022
Deviations from a typical development of the cerebellum in youth are associated with psychopathology, executive functions and educational outcomes
Borges M, Hoffmann M, Simioni A, Axelrud L, Teixeira D, Zugman A, Jackowski A, Pan P, Bressan R, Parker N, Germann J, Bado P, Satterthwaite T, Milham M, Chakravarty M, Rohde L, Miguel E, Paus T, Salum G. Deviations from a typical development of the cerebellum in youth are associated with psychopathology, executive functions and educational outcomes. Psychological Medicine 2022, 53: 5698-5708. PMID: 36226568, DOI: 10.1017/s0033291722002926.Peer-Reviewed Original ResearchConceptsExecutive functionTypical developmentInhibitory controlAcademic achievementCerebellar volumeHigher executive functionChild Behavior ChecklistTypical brain developmentSchool achievementBehavior ChecklistMental health conditionsStandardized measuresMediation analysisMental healthHigh Risk Cohort StudyEducational outcomesPsychopathologyBrain developmentMental conditionLongitudinal analysisYouthSpecific factorsAchievementCognitionAdolescence
2019
Relationships between childhood maltreatment, impairment in executive functions and disruptive behavior disorders in a community sample of children
Bernardes E, Manitto A, Miguel E, Pan P, Batistuzzo M, Rohde L, Polanczyk G. Relationships between childhood maltreatment, impairment in executive functions and disruptive behavior disorders in a community sample of children. European Child & Adolescent Psychiatry 2019, 29: 969-978. PMID: 31559500, DOI: 10.1007/s00787-019-01408-3.Peer-Reviewed Original ResearchConceptsDisruptive behavior disordersExecutive functionChildhood maltreatmentCognitive flexibilityEF performanceCommunity sampleBehavior disorderSchool-based sampleCognitive mechanismsCognitive tasksInhibitory controlDisruptive behaviorChild maltreatmentMaltreatmentWorse performanceMental disordersModeratorChildrenImpairmentDisordersIndependent relationshipMemoryFuture studiesAssociationTaskGenetic risk for Alzheimer's disease and functional brain connectivity in children and adolescents
Axelrud L, Sato J, Santoro M, Talarico F, Pine D, Rohde L, Zugman A, Junior E, Bressan R, Grassi-Oliveira R, Pan P, Hoffmann M, Simioni A, Guinjoan S, Hakonarson H, Brietzke E, Gadelha A, Pellegrino da Silva R, Hoexter M, Miguel E, Belangero S, Salum G. Genetic risk for Alzheimer's disease and functional brain connectivity in children and adolescents. Neurobiology Of Aging 2019, 82: 10-17. PMID: 31376729, PMCID: PMC7658444, DOI: 10.1016/j.neurobiolaging.2019.06.011.Peer-Reviewed Original ResearchConceptsAlzheimer's diseaseAD-PRSBrain connectivityGenetic riskRight superior temporal gyrusFunctional brain connectivityMagnetic resonance imagingInhibitory controlSuperior temporal gyrusTau pathologyAD developmentPolygenic risk scoresRisk scoreRight precuneusResonance imagingTau proteinTemporal gyrusDiseaseBrain connectionsEarly lifePathology networkFunctional networksRiskPorto AlegreMemory performance
2015
Visuospatial Memory Improvement after Gamma Ventral Capsulotomy in Treatment Refractory Obsessive–Compulsive Disorder Patients
Batistuzzo M, Hoexter M, Taub A, Gentil A, Cesar R, Joaquim M, D'Alcante C, McLaughlin N, Canteras M, Shavitt R, Savage C, Greenberg B, Norén G, Miguel E, Lopes A. Visuospatial Memory Improvement after Gamma Ventral Capsulotomy in Treatment Refractory Obsessive–Compulsive Disorder Patients. Neuropsychopharmacology 2015, 40: 1837-1845. PMID: 25645373, PMCID: PMC4839507, DOI: 10.1038/npp.2015.33.Peer-Reviewed Original ResearchConceptsObsessive-compulsive disorderRefractory OCD patientsOCD patientsVisuospatial memory performanceComprehensive neuropsychological evaluationObsessive-compulsive disorder patientsTreatment-refractory obsessive-compulsive disorder patientsCognitive flexibilityNeuropsychological domainsMemory performanceVisuospatial learningNeuropsychological functioningVisuospatial perceptionIntellectual functioningInhibitory controlRefractory obsessive-compulsive disorderTreatment-refractory OCD patientsMemory improvementGamma ventral capsulotomyMotor functioningNeuropsychological evaluationNeuropsychological outcomesEffects of GVCMotor performanceFunctioning
2014
Decreased centrality of subcortical regions during the transition to adolescence: A functional connectivity study
Sato J, Salum G, Gadelha A, Vieira G, Zugman A, Picon F, Pan P, Hoexter M, Anés M, Moura L, Del’Aquilla M, Crossley N, Amaro E, Mcguire P, Lacerda A, Rohde L, Miguel E, Jackowski A, Bressan R. Decreased centrality of subcortical regions during the transition to adolescence: A functional connectivity study. NeuroImage 2014, 104: 44-51. PMID: 25290886, DOI: 10.1016/j.neuroimage.2014.09.063.Peer-Reviewed Original ResearchConceptsAngular gyrusDevelopmental trajectoriesFunctional magnetic resonance imaging (fMRI) dataBrain developmental trajectoriesBrazilian community sampleBrain maturation processesFunctional connectivity studiesNetwork connectivity changesStructural imaging findingsInhibitory controlSensitive development periodCommunity sampleEmotional changesAbstract thoughtMagnetic resonance imaging dataComplex reasoningFMRI dataCerebellar regionsDevelopmental changesBrain regionsCortical regionsConnectivity changesConnectivity studiesSubcortical regionsAdolescence