2023
Brazilian Research Consortium on Obsessive-Compulsive Spectrum Disorders guidelines for the treatment of adult obsessive-compulsive disorder. Part I: pharmacological treatment
de Oliveira M, de Barros P, de Mathis M, Boavista R, Chacon P, Echevarria M, Ferrão Y, de Queiroz Vattimo E, Lopes A, Torres A, Diniz J, Fontenelle L, do Rosário M, Shavitt R, Miguel E, da Silva R, da Conceição Costa D. Brazilian Research Consortium on Obsessive-Compulsive Spectrum Disorders guidelines for the treatment of adult obsessive-compulsive disorder. Part I: pharmacological treatment. Brazilian Journal Of Psychiatry 2023, 45: 146-161. PMID: 36749887, PMCID: PMC10154009, DOI: 10.47626/1516-4446-2022-2891.Peer-Reviewed Original ResearchConceptsSelective serotonin reuptake inhibitorsAdult obsessive-compulsive disorderObsessive-compulsive disorderPharmacological treatmentReuptake inhibitorsEvidence-based pharmacological interventionsFirst-line pharmacological treatmentAmerican Psychiatric Association guidelinesEvidence-based pharmacological treatmentFirst-line treatmentNorepinephrine reuptake inhibitorsPrimary outcome measureSerotonin reuptake inhibitorsGlutamate-modulating agentsHigh-quality evidenceAmerican Heart AssociationLevel of evidenceTreatment of OCDBrazilian Research ConsortiumAdult patientsHeart AssociationTolerable dosesAssociation guidelinesTreatment recommendationsPharmacological interventionsBrazilian Research Consortium on Obsessive-Compulsive Spectrum Disorders guidelines for the treatment of adult obsessive-compulsive disorder. Part II: cognitive-behavioral therapy
de Mathis M, Chacon P, Boavista R, de Oliveira M, de Barros P, Echevarria M, Ferrão Y, de Queiroz Vattimo E, Lopes A, Torres A, Diniz J, Fontenelle L, do Rosário M, Shavitt R, da Silva R, Miguel E, da Conceição Costa D. Brazilian Research Consortium on Obsessive-Compulsive Spectrum Disorders guidelines for the treatment of adult obsessive-compulsive disorder. Part II: cognitive-behavioral therapy. Brazilian Journal Of Psychiatry 2023, 45: 431-447. PMID: 37718254, PMCID: PMC10894635, DOI: 10.47626/1516-4446-2023-3081.Peer-Reviewed Original ResearchAdult obsessive-compulsive disorderObsessive-compulsive disorderTherapy treatmentHigh-quality scientific evidenceTreatment of adultsPrimary outcome measureHigh-quality evidenceAmerican Heart AssociationLevel of evidenceInternet-delivered CBTCognitive behavioral therapy treatmentBrazilian Research ConsortiumAdult patientsHeart AssociationClinical guidelinesTreatment recommendationsOutcome measuresAmerican CollegeSystematic reviewCBT interventionClinical interventionsCBT treatmentStudy designCBT protocolResponse prevention
2019
The impact of attention deficit hyperactivity disorder in obsessive‐compulsive disorder subjects
Blanco‐Vieira T, Santos M, Ferrão YA, Torres AR, Miguel EC, Bloch MH, Leckman JF, do Rosario MC. The impact of attention deficit hyperactivity disorder in obsessive‐compulsive disorder subjects. Depression And Anxiety 2019, 36: 533-542. PMID: 30990937, DOI: 10.1002/da.22898.Peer-Reviewed Original ResearchConceptsAttention deficit hyperactivity disorderAdult OCD patientsObsessive-compulsive disorderDeficit hyperactivity disorderOCD patientsClinical characteristicsExact testFeatures of ADHDHyperactivity disorderSubgroup of patientsAdult obsessive-compulsive disorderComorbid attention deficit hyperactivity disorderSpecific clinical featuresCross-sectional studyObsessive-compulsive disorder (OCD) subjectsLogistic regression analysisFisher's exact testBrazilian Research ConsortiumMann-Whitney testAdult patientsRheumatic feverDevelopment of interventionsClinical featuresObsessive-compulsive spectrum disordersLifetime prevalence
2016
Use of benzodiazepines in obsessive–compulsive disorder
Starcevic V, Berle D, do Rosário M, Brakoulias V, Ferrão Y, Viswasam K, Shavitt R, Miguel E, Fontenelle L. Use of benzodiazepines in obsessive–compulsive disorder. International Clinical Psychopharmacology 2016, 31: 27-33. PMID: 26426443, DOI: 10.1097/yic.0000000000000100.Peer-Reviewed Original ResearchMeSH KeywordsAdultAnti-Anxiety AgentsAnxietyBenzodiazepinesCross-Sectional StudiesDiagnostic and Statistical Manual of Mental DisordersDrug Therapy, CombinationFemaleHumansMaleMiddle AgedObsessive-Compulsive DisorderPsychiatric Status Rating ScalesSelective Serotonin Reuptake InhibitorsSocioeconomic FactorsConceptsObsessive-compulsive disorderBDZ useOCD patientsUse of benzodiazepinesTreatment of OCDBrazilian Research ConsortiumAdditional medicationTreatment guidelinesMulticentre studyReuptake inhibitorsObsessive-compulsive spectrum disordersBenzodiazepine useMarked anxietyPatientsMedicationsBDZDisordersResearch ConsortiumCurrent age
2015
Comorbidity variation in patients with obsessive–compulsive disorder according to symptom dimensions: Results from a large multicentre clinical sample
Torres A, Fontenelle L, Shavitt R, Ferrão Y, do Rosário M, Storch E, Miguel E. Comorbidity variation in patients with obsessive–compulsive disorder according to symptom dimensions: Results from a large multicentre clinical sample. Journal Of Affective Disorders 2015, 190: 508-516. PMID: 26561941, DOI: 10.1016/j.jad.2015.10.051.Peer-Reviewed Original ResearchConceptsPosttraumatic stress disorderObsessive-compulsive disorderAnxiety disordersTic disordersDimensional Yale-Brown Obsessive Compulsive ScaleSeparation anxiety disorderComorbid disordersSymptom dimensionsDifferent underlying pathogenic mechanismsTertiary mental health servicesDSM-IV Axis I DisordersSpecific phobiaMulticenter clinical studyPanic disorder/agoraphobiaAxis I DisordersStructured Clinical InterviewYale-Brown Obsessive Compulsive ScaleMental health servicesUnderlying pathogenic mechanismsImpulse control disordersBrazilian Research ConsortiumSocial phobiaBody dysmorphic disorderObsessive Compulsive ScaleCommon comorbiditiesSeparation anxiety disorder in adult patients with obsessive-compulsive disorder: Prevalence and clinical correlates
Franz A, Rateke L, Hartmann T, McLaughlin N, Torres A, do Rosário M, Filho E, Ferrão Y. Separation anxiety disorder in adult patients with obsessive-compulsive disorder: Prevalence and clinical correlates. European Psychiatry 2015, 30: 145-151. PMID: 24908152, DOI: 10.1016/j.eurpsy.2014.04.007.Peer-Reviewed Original ResearchConceptsObsessive-compulsive disorderSeparation anxiety disorderPsychiatric comorbidityAnxiety disordersMore psychiatric comorbiditiesCross-sectional studyMultiple logistic regressionSpecific psychiatric comorbiditiesPrimary obsessive-compulsive disorderBrazilian Research ConsortiumSensory phenomenaGroup patientsAdult patientsHigh morbidityClinical correlatesSymptom assessmentPoor responsePrognostic evaluationLifetime diagnosisPatientsSuch symptomsSocio-demographic variablesLogistic regressionOCD patientsDisorders
2014
Phenomenology of OCD: Lessons from a large multicenter study and implications for ICD-11
Shavitt R, de Mathis M, Oki F, Ferrao Y, Fontenelle L, Torres A, Diniz J, Costa D, do Rosário M, Hoexter M, Miguel E, Simpson H. Phenomenology of OCD: Lessons from a large multicenter study and implications for ICD-11. Journal Of Psychiatric Research 2014, 57: 141-148. PMID: 25012187, PMCID: PMC7326117, DOI: 10.1016/j.jpsychires.2014.06.010.Peer-Reviewed Original Research
2013
Panic Disorder and Agoraphobia in OCD patients: Clinical profile and possible treatment implications
Torres A, Ferrão Y, Shavitt R, Diniz J, Costa D, do Rosário M, Miguel E, Fontenelle L. Panic Disorder and Agoraphobia in OCD patients: Clinical profile and possible treatment implications. Comprehensive Psychiatry 2013, 55: 588-597. PMID: 24374170, DOI: 10.1016/j.comppsych.2013.11.017.Peer-Reviewed Original ResearchConceptsObsessive-compulsive disorderPanic disorderClinical profileOCD patientsMajor depressionPrevalence of PDDSM-IV-TR Axis I DisordersCross-sectional studyAxis I DisordersStructured Clinical InterviewPD/agoraphobiaBrazilian Research ConsortiumLogistic regression modelsPosttraumatic stress disorderLarge clinical sampleYale-Brown ObsessiveComorbid conditionsPD comorbidityIndependent correlatesObsessive-compulsive spectrum disordersLifetime prevalenceTreatment strategiesI disordersStudy groupSeparation anxiety disorderLate-onset obsessive-compulsive disorder: Risk factors and correlates
Frydman I, do Brasil PE, Torres AR, Shavitt RG, Ferrão YA, Rosário MC, Miguel EC, Fontenelle LF. Late-onset obsessive-compulsive disorder: Risk factors and correlates. Journal Of Psychiatric Research 2013, 49: 68-74. PMID: 24267559, DOI: 10.1016/j.jpsychires.2013.10.021.Peer-Reviewed Original ResearchConceptsObsessive-compulsive disorderLate-onset obsessive-compulsive disorderSubclinical obsessive-compulsive symptomsPosttraumatic stress disorderObsessive-compulsive symptomsOnset obsessive-compulsive disorderObsessive-compulsive spectrum disordersMajor traumatic eventEarly-onset obsessive-compulsive disorderBrazilian Research ConsortiumTraumatic eventsSpectrum disorderStress disorderOCD symptomsOCD onsetDearth of studiesSelfCorrelatesDisordersPotential variablesNeural networkDistressSymptomsSizeable proportionSeries of modelsClinical features of pure obsessive-compulsive disorder
Torres A, Shavitt R, Torresan R, Ferrão Y, Miguel E, Fontenelle L. Clinical features of pure obsessive-compulsive disorder. Comprehensive Psychiatry 2013, 54: 1042-1052. PMID: 23746710, DOI: 10.1016/j.comppsych.2013.04.013.Peer-Reviewed Original ResearchConceptsPure obsessive-compulsive disorderNon-comorbid patientsObsessive-compulsive disorderYale-Brown ObsessiveClinical characteristicsDSM-IV Axis I DisordersSuicidal thoughtsLogistic regressionCompulsive ScaleOCD patientsAnxious symptomsAxis I comorbidityCross-sectional studyAxis I DisordersStructured Clinical InterviewCo-occurring disordersPrevious suicidal thoughtsBrazilian Research ConsortiumLarge multicenter samplePure OCD patientsAdult patientsClinical featuresLifetime comorbidityPsychiatric comorbidityObsessive-compulsive spectrum disordersSymptom dimensions, clinical course and comorbidity in men and women with obsessive-compulsive disorder
Torresan R, Ramos-Cerqueira A, Shavitt R, do Rosário M, de Mathis M, Miguel E, Torres A. Symptom dimensions, clinical course and comorbidity in men and women with obsessive-compulsive disorder. Psychiatry Research 2013, 209: 186-195. PMID: 23298952, DOI: 10.1016/j.psychres.2012.12.006.Peer-Reviewed Original ResearchConceptsObsessive-compulsive disorderClinical courseComorbid post-traumatic stress disorderDSM-IV Axis ICross-sectional studyStructured Clinical InterviewAlcohol use disorderSymptom dimensionsPost-traumatic stress disorderAdult OCD patientsBrazilian Research ConsortiumYale-Brown ObsessiveFemale patientsClinical presentationMean ageSymptom interferenceObsessive-compulsive spectrum disordersMajor depressionTic disordersFemale genderAxis IUse disordersClinical InterviewAnorexia nervosaSkin picking
2012
Social phobia in obsessive-compulsive disorder: Prevalence and correlates
Assunção M, da Conceição Costa D, de Mathis M, Shavitt R, Ferrão Y, do Rosário M, Miguel E, Torres A. Social phobia in obsessive-compulsive disorder: Prevalence and correlates. Journal Of Affective Disorders 2012, 143: 138-147. PMID: 22858214, DOI: 10.1016/j.jad.2012.05.044.Peer-Reviewed Original ResearchMeSH KeywordsAdultAnalysis of VarianceAnxiety DisordersBody Dysmorphic DisordersBrazilComorbidityCross-Sectional StudiesDiagnostic and Statistical Manual of Mental DisordersFemaleHumansMaleMiddle AgedObsessive-Compulsive DisorderPhobic DisordersPrevalenceRetrospective StudiesSex FactorsSocial ClassTourette SyndromeConceptsObsessive-compulsive disorderDSM-IV Axis I DisordersLogistic regressionSocial phobiaAnxiety disordersOCD patientsCross-sectional studyStructured Clinical InterviewAxis I DisordersLow socioeconomic statusBrazilian Research ConsortiumLarge multicenter sampleBroader treatment approachesGeneralized anxiety disorderBody dysmorphic disorderYale-Brown ObsessiveClinical factorsCross-sectional designSpecific comorbiditiesMale sexObsessive-compulsive spectrum disordersUnivariate analysisLifetime prevalenceI disordersTourette syndromeBODY DYSMORPHIC DISORDER IN PATIENTS WITH OBSESSIVE–COMPULSIVE DISORDER: PREVALENCE AND CLINICAL CORRELATES
Costa D, Assunção M, Ferrão Y, Conrado L, Gonzalez C, Fontenelle L, Fossaluza V, Miguel E, Torres A, Shavitt R. BODY DYSMORPHIC DISORDER IN PATIENTS WITH OBSESSIVE–COMPULSIVE DISORDER: PREVALENCE AND CLINICAL CORRELATES. Depression And Anxiety 2012, 29: 966-975. PMID: 22815241, DOI: 10.1002/da.21980.Peer-Reviewed Original ResearchConceptsBody dysmorphic disorderObsessive-compulsive disorderSkin pickingYale-Brown ObsessiveDSM-IV Axis I DisordersClinical Global Impression ScaleEarly onsetCompulsive ScaleOCD patientsDysmorphic disorderGroup of patientsSymptoms of BDDGlobal Impression ScaleAxis I DisordersStructured Clinical InterviewComorbid body dysmorphic disorderBrazilian Research ConsortiumYounger patientsUnemployed patientsClinical featuresObsessive-compulsive spectrum disordersClinical correlatesImpression ScaleChronic depressionClinical assessmentClinical correlates of social adjustment in patients with obsessive-compulsive disorder
Rosa A, Diniz J, Fossaluza V, Torres A, Fontenelle L, De Mathis A, da Conceição Rosário M, Miguel E, Shavitt R. Clinical correlates of social adjustment in patients with obsessive-compulsive disorder. Journal Of Psychiatric Research 2012, 46: 1286-1292. PMID: 22800713, DOI: 10.1016/j.jpsychires.2012.05.019.Peer-Reviewed Original ResearchConceptsObsessive-compulsive disorderPoor social adjustmentSocial adjustmentSocial functioningOverall social functioningYale-Brown ObsessiveOCD severityReligious obsessionsCompulsive ScaleCurrent post-traumatic stress disorderSpecific OCD symptomsPost-traumatic stress disorderPrimary DSM-IV diagnosisOCD symptom onsetPoor social functioningSocial adjustment measuresObsessive-compulsive spectrum disordersGreater OCD severitySocial Adjustment ScaleBrazilian Research ConsortiumPoorer overall social functioningDimensional Yale-Brown ObsessivePsychiatric comorbidityCurrent psychiatric comorbidityCurrent major depressive disorderClinical features of obsessive-compulsive disorder with hoarding symptoms: A multicenter study
Torres A, Fontenelle L, Ferrão Y, do Rosário M, Torresan R, Miguel E, Shavitt R. Clinical features of obsessive-compulsive disorder with hoarding symptoms: A multicenter study. Journal Of Psychiatric Research 2012, 46: 724-732. PMID: 22464941, DOI: 10.1016/j.jpsychires.2012.03.005.Peer-Reviewed Original ResearchConceptsObsessive-compulsive disorderClinical featuresOCD patientsLogistic regressionDSM-IV OCD patientsCertain clinical featuresCross-sectional studyAttention-deficit/hyperactivity disorderStatistical univariate analysisBrazilian Research ConsortiumDeficit/hyperactivity disorderHigher anxiety scoresYale-Brown ObsessiveSymptom onsetInsidious onsetMulticenter studyObsessive-compulsive spectrum disordersSectional studyPossible confoundersUnivariate analysisTic disordersHoarding dimensionPatientsSymptomsPoor insight
2011
Suicidality in obsessive-compulsive disorder: prevalence and relation to symptom dimensions and comorbid conditions.
Torres A, Ramos-Cerqueira A, Ferrão Y, Fontenelle L, do Rosário M, Miguel E. Suicidality in obsessive-compulsive disorder: prevalence and relation to symptom dimensions and comorbid conditions. The Journal Of Clinical Psychiatry 2011, 72: 17-26; quiz 119-20. PMID: 21272513, DOI: 10.4088/jcp.09m05651blu.Peer-Reviewed Original ResearchMeSH KeywordsAdultComorbidityCross-Sectional StudiesDepressive Disorder, MajorDisruptive, Impulse Control, and Conduct DisordersFemaleHumansLongitudinal StudiesMaleObsessive-Compulsive DisorderPersonality InventoryPrevalenceReligion and PsychologyRisk FactorsSexual BehaviorStress Disorders, Post-TraumaticSuicideSuicide, AttemptedSurveys and QuestionnairesConceptsPosttraumatic stress disorderMajor depressive disorderObsessive-compulsive disorderYale-Brown Obsessive Compulsive ScaleCurrent suicidal thoughtsSubstance use disordersImpulse control disordersSuicidal thoughtsObsessive Compulsive ScaleDepressive disorderUse disordersDSM-IV Axis I DisordersSuicidal behaviorComorbid substance use disorderCompulsive ScaleOCD patientsLifetime major depressive disorderCross-sectional studyStructured Clinical InterviewAxis I DisordersLogistic regression analysisPrimary obsessive-compulsive disorderSymptom dimensionsLifetime suicidal thoughtsBrazilian Research Consortium