2022
Not only pharmacodynamic: the role of brain circuits in improving the treatment of suicidal thoughts and behaviors
Damiano R, Miguel E, Shephard E. Not only pharmacodynamic: the role of brain circuits in improving the treatment of suicidal thoughts and behaviors. Brazilian Journal Of Psychiatry 2022, 44: 113-113. PMID: 35170674, PMCID: PMC8827373, DOI: 10.1590/1516-4446-2021-2257.Peer-Reviewed Original Research
2020
Toward identifying reproducible brain signatures of obsessive-compulsive profiles: rationale and methods for a new global initiative
Simpson H, van den Heuvel O, Miguel E, Reddy Y, Stein D, Lewis-Fernández R, Shavitt R, Lochner C, Pouwels P, Narayanawamy J, Venkatasubramanian G, Hezel D, Vriend C, Batistuzzo M, Hoexter M, de Joode N, Costa D, de Mathis M, Sheshachala K, Narayan M, van Balkom A, Batelaan N, Venkataram S, Cherian A, Marincowitz C, Pannekoek N, Stovezky Y, Mare K, Liu F, Otaduy M, Pastorello B, Rao R, Katechis M, Van Meter P, Wall M. Toward identifying reproducible brain signatures of obsessive-compulsive profiles: rationale and methods for a new global initiative. BMC Psychiatry 2020, 20: 68. PMID: 32059696, PMCID: PMC7023814, DOI: 10.1186/s12888-020-2439-2.Peer-Reviewed Original ResearchConceptsMagnetic resonance imagingCircuit abnormalitiesNew global initiativesBrain signaturesGlobal InitiativeHealthy control subjectsMedication-free adultsMultiple brain circuitsMedication-free subjectsBackgroundObsessive–compulsive disorderClinical profileClinical symptomsControl subjectsClinical evaluationHealthy controlsLeading causeGlobal disabilityLifetime prevalenceResonance imagingNeurocognitive assessmentBrain circuitsImaging signaturesFunctional connectivityBrain-behavior associationsDisease dimensions
2019
Obsessive–compulsive disorder
Stein D, Costa D, Lochner C, Miguel E, Reddy Y, Shavitt R, van den Heuvel O, Simpson H. Obsessive–compulsive disorder. Nature Reviews Disease Primers 2019, 5: 52. PMID: 31371720, PMCID: PMC7370844, DOI: 10.1038/s41572-019-0102-3.Peer-Reviewed Original ResearchConceptsObsessive-compulsive disorderSimilar symptom dimensionsExtent of comorbiditySpecific brain circuitsGroup of conditionsTranslational Neuroscience ApproachCognitive behavioral therapyIntractable symptomsReuptake inhibitorsClinical outcomesChronic conditionsGlobal disabilityEffective treatmentInternational ClassificationGlobal mental healthRelated disordersMental disordersNeuropsychiatric disordersRepetitive stereotyped behaviorsBrain circuitsIndividualized assessmentMental healthNeurobiological mechanismsStatistical ManualHomogenous disorder
2016
Transcranial direct current stimulation for treatment-resistant obsessive-compulsive disorder: report on two cases and proposal for a randomized, sham-controlled trial
da Silva R, Brunoni A, Miguel E, Shavitt R. Transcranial direct current stimulation for treatment-resistant obsessive-compulsive disorder: report on two cases and proposal for a randomized, sham-controlled trial. Sao Paulo Medical Journal 2016, 134: 446-450. PMID: 27901245, PMCID: PMC10871858, DOI: 10.1590/1516-3180.2016.0155010716.Peer-Reviewed Original ResearchConceptsTreatment-resistant obsessive-compulsive disorderTranscranial direct current stimulationObsessive-compulsive disorderDirect current stimulationClinical trialsCurrent stimulationSham-controlled trialSerotonin reuptake inhibitorsSupplementary motor cortexPrimary obsessive-compulsive disorderCognitive behavioral therapySecondary outcomesPrimary outcomeReuptake inhibitorsSham interventionFirst patientCortical excitabilityMotor cortexUniversity HospitalWeek 4YBOCS scoresNeuromodulation techniquesNon-invasive techniqueBrain circuitsPatients
2015
Transcranial direct current stimulation in obsessive–compulsive disorder: emerging clinical evidence and considerations for optimal montage of electrodes
Senço N, Huang Y, D’Urso G, Parra L, Bikson M, Mantovani A, Shavitt R, Hoexter M, Miguel E, Brunoni A. Transcranial direct current stimulation in obsessive–compulsive disorder: emerging clinical evidence and considerations for optimal montage of electrodes. Expert Review Of Medical Devices 2015, 12: 381-391. PMID: 25982412, PMCID: PMC5777161, DOI: 10.1586/17434440.2015.1037832.Peer-Reviewed Original ResearchConceptsTranscranial direct current stimulationDirect current stimulationSystematic reviewCurrent stimulationPotential new treatmentPre-supplementary motor areaPubMed/MEDLINEObsessive-compulsive disorder (OCD) treatmentDeep brain stimulation trialsClinical evidenceObsessive-compulsive disorderStimulation trialsDBS trialsMotor areaRTMS targetsMagnetic stimulationEligibility criteriaNeuromodulation techniquesStimulation targetsDisorder treatmentNew treatmentsBrain circuitsDifferent electrode montagesTDCS montageTrials