2018
Impaired Recovery of Left Ventricular Function in Patients With Cardiomyopathy and Left Bundle Branch Block
Sze E, Samad Z, Dunning A, Campbell KB, Loring Z, Atwater BD, Chiswell K, Kisslo JA, Velazquez EJ, Daubert JP. Impaired Recovery of Left Ventricular Function in Patients With Cardiomyopathy and Left Bundle Branch Block. Journal Of The American College Of Cardiology 2018, 71: 306-317. PMID: 29348023, PMCID: PMC8352572, DOI: 10.1016/j.jacc.2017.11.020.Peer-Reviewed Original ResearchConceptsGuideline-directed medical therapyLeft bundle branch blockCardiac resynchronization therapyWide QRS durationBundle branch blockQRS durationLVEF improvementQRS morphologyReduced LVEFBranch blockLeft ventricular ejection fraction improvementVentricular ejection fraction improvementEjection fraction improvementMean LVEF improvementNarrow QRS durationSevere valve diseaseFirst-line therapyHeart failure hospitalizationLeft ventricular functionVentricular assist deviceBaseline electrocardiographyFailure hospitalizationCombined endpointSignificant comorbiditiesResynchronization therapy
2010
Impact of early surgery on survival of patients with severe mitral regurgitation
Samad Z, Kaul P, Shaw LK, Glower DD, Velazquez EJ, Douglas PS, Jollis JG. Impact of early surgery on survival of patients with severe mitral regurgitation. Heart 2010, 97: 221. PMID: 21071750, DOI: 10.1136/hrt.2010.202432.Peer-Reviewed Original ResearchConceptsSevere mitral regurgitationDegenerative mitral regurgitationEarly surgery groupLate surgery groupEarly surgeryMitral regurgitationSurgery groupLate surgeryGuideline indicationsOptimal timingValve diseaseMV repairAdjusted Cox regression modelCongenital mitral valve diseaseValve repair/replacementSevere degenerative mitral regurgitationACC/AHA guideline recommendationsSevere valve diseaseSurvival of patientsTiming of surgeryMitral valve diseaseCox regression modelLong-term survivalEarly referralCoronary disease