2015
Response to Letter Regarding Article, “Surgical Revascularization Is Associated With Maximal Survival in Patients With Ischemic Mitral Regurgitation
Castleberry AW, Williams JB, Daneshmand MA, Honeycutt E, Shaw LK, Samad Z, Lopes RD, Alexander JH, Mathew JP, Velazquez EJ, Milano CA, Smith PK. Response to Letter Regarding Article, “Surgical Revascularization Is Associated With Maximal Survival in Patients With Ischemic Mitral Regurgitation. Circulation 2015, 131: e378-e379. PMID: 25779550, PMCID: PMC5126645, DOI: 10.1161/circulationaha.114.013125.Peer-Reviewed Original ResearchConceptsIschemic mitral regurgitationSurgical revascularizationMitral regurgitationMaximal survivalRevascularizationRegurgitationPatients
2014
Surgical Revascularization Is Associated With Maximal Survival in Patients With Ischemic Mitral Regurgitation
Castleberry AW, Williams JB, Daneshmand MA, Honeycutt E, Shaw LK, Samad Z, Lopes RD, Alexander JH, Mathew JP, Velazquez EJ, Milano CA, Smith PK. Surgical Revascularization Is Associated With Maximal Survival in Patients With Ischemic Mitral Regurgitation. Circulation 2014, 129: 2547-2556. PMID: 24744275, PMCID: PMC4142433, DOI: 10.1161/circulationaha.113.005223.Peer-Reviewed Original ResearchMeSH KeywordsAgedCoronary Artery BypassDatabases, BibliographicFemaleFollow-Up StudiesHeart Valve Prosthesis ImplantationHumansKaplan-Meier EstimateMaleMiddle AgedMitral ValveMitral Valve InsufficiencyMyocardial IschemiaMyocardial RevascularizationPercutaneous Coronary InterventionProportional Hazards ModelsRetrospective StudiesRisk FactorsSeverity of Illness IndexStentsConceptsIschemic mitral regurgitationPercutaneous coronary interventionMitral valve repairSignificant coronary artery diseaseSevere ischemic mitral regurgitationCoronary artery diseaseMitral regurgitationCoronary interventionValve repairMedical treatmentArtery diseaseTreatment strategiesLower mortalityMultivariable Cox proportional hazards analysisCox proportional hazards analysisCoronary artery bypassMitral valve surgeryKaplan-Meier methodProportional hazards analysisMitral regurgitation severitySurgical revascularizationArtery bypassValve surgeryOptimal treatmentCABG
2012
Influence of Mitral Regurgitation Repair on Survival in the Surgical Treatment for Ischemic Heart Failure Trial
Deja MA, Grayburn PA, Sun B, Rao V, She L, Krejca M, Jain AR, Chua Y, Daly R, Senni M, Mokrzycki K, Menicanti L, Oh JK, Michler R, Wróbel K, Lamy A, Velazquez EJ, Lee KL, Jones RH. Influence of Mitral Regurgitation Repair on Survival in the Surgical Treatment for Ischemic Heart Failure Trial. Circulation 2012, 125: 2639-2648. PMID: 22553307, PMCID: PMC3776601, DOI: 10.1161/circulationaha.111.072256.Peer-Reviewed Original ResearchConceptsSevere mitral regurgitationMild mitral regurgitationMitral regurgitationMitral valve repairTrace mitral regurgitationMitral surgeryMedical therapyValve repairIschemic Heart Failure (STICH) trialCoronary artery bypassHeart Failure TrialPrimary end pointLeft ventricular dysfunctionCoronary artery diseaseModerate mitral regurgitationBaseline prognostic variablesIschemic mitral regurgitationArtery bypassRandomized patientsVentricular dysfunctionHazard ratioArtery diseaseEjection fractionMedical armSurgical treatmentMechanisms and Predictors of Mitral Regurgitation after High-Risk Myocardial Infarction
Meris A, Amigoni M, Verma A, Thune JJ, Køber L, Velazquez E, McMurray JJ, Pfeffer MA, Califf R, Levine RA, Solomon SD, Investigators V. Mechanisms and Predictors of Mitral Regurgitation after High-Risk Myocardial Infarction. Journal Of The American Society Of Echocardiography 2012, 25: 535-542. PMID: 22305962, PMCID: PMC3501447, DOI: 10.1016/j.echo.2012.01.006.Peer-Reviewed Original ResearchMeSH KeywordsAdultAge FactorsAgedAngiotensin-Converting Enzyme InhibitorsCaptoprilDisease ProgressionEchocardiography, Doppler, ColorElectrocardiographyFemaleFollow-Up StudiesHumansMaleMiddle AgedMitral Valve InsufficiencyMonitoring, PhysiologicMultivariate AnalysisMyocardial InfarctionPredictive Value of TestsProspective StudiesReference ValuesReproducibility of ResultsRisk AssessmentROC CurveSeverity of Illness IndexSex FactorsStatistics, NonparametricStroke VolumeTetrazolesTime FactorsValineValsartanVentricular Dysfunction, LeftVentricular RemodelingConceptsHigh-risk myocardial infarctionBaseline mitral regurgitationMitral regurgitationMyocardial infarctionAtrial sizeIndependent predictorsCoaptation depthProgression of MRMitral valve deformationStructural valve diseaseSevere mitral regurgitationFunctional mitral regurgitationIschemic mitral regurgitationGood-quality echocardiogramsMitral annular areaMitral tentingMR degreeLV dysfunctionTenting areaBaseline characteristicsDiastolic functionHeart failureValve diseaseLV remodelingVentricular remodeling