2023
Left Ventricular Global Longitudinal Strain Before TAVR Time to Jump the Ejection Fraction Ship? ∗
Desai M, Akintoye E. Left Ventricular Global Longitudinal Strain Before TAVR Time to Jump the Ejection Fraction Ship? ∗. JACC Cardiovascular Imaging 2023, 16: 342-344. PMID: 36889850, DOI: 10.1016/j.jcmg.2023.01.011.Peer-Reviewed Original Research
2022
Impact of chronic kidney disease on in-hospital mortality and clinical outcomes of catheter ablation of ventricular tachycardia: Insights from the national readmission database
Khalil M, Maraey A, Aglan A, Akintoye E, Salem M, Elzanaty A, Younes A, Saeyeldin A, Barbhaiya C, Shokr M. Impact of chronic kidney disease on in-hospital mortality and clinical outcomes of catheter ablation of ventricular tachycardia: Insights from the national readmission database. Journal Of Interventional Cardiac Electrophysiology 2022, 66: 323-331. PMID: 35314904, DOI: 10.1007/s10840-022-01187-z.Peer-Reviewed Original ResearchConceptsChronic kidney diseaseNational Readmission DatabaseClinical outcomesVentricular tachycardiaCatheter ablationKidney diseaseHospital mortalityVT ablationOdds ratioCorresponding diagnosis codesUnderwent catheter ablationAcute kidney injuryTotal hospital chargesWorse clinical outcomesMean lengthMultivariable regression analysisCKD groupConclusionIn patientsGroup patientsKidney injurySecondary outcomesHospital chargesDiagnosis codesClinical dataEffective treatmentRilonacept for the treatment of recurrent pericarditis
Fava A, Reyaldeen R, Presti S, Goyal A, Akintoye E, Hughes D, Klein A. Rilonacept for the treatment of recurrent pericarditis. Expert Opinion On Biological Therapy 2022, 22: 7-16. PMID: 34757872, DOI: 10.1080/14712598.2022.2005024.Peer-Reviewed Original ResearchMeSH KeywordsHumansInjections, SubcutaneousInterleukin-1PericarditisRecombinant Fusion ProteinsTreatment OutcomeConceptsRecurrent pericarditisC-reactive proteinClinical trialsUpper respiratory tract infectionSafety of rilonaceptCommon adverse eventsRespiratory tract infectionsAvailable clinical trialsInjection site reactionsRapid clinical responseValuable therapeutic optionGood safety profilePromising new therapyIL-1β signalingDimeric fusion proteinGlucocorticoid-dependent diseasesAdverse eventsClinical responseTherapy durationTract infectionsSuccessful weaningRecurrence rateSafety profileTherapeutic optionsFuture trials
2020
Intermediate and Late Outcomes With PCI vs CABG for Left Main Disease — Landmark Meta-Analysis of Randomized Trials
Akintoye E, Salih M, Olagoke O, Oseni A, Sistla P, Alqasrawi M, Panos A, Panaich S, Sellke F. Intermediate and Late Outcomes With PCI vs CABG for Left Main Disease — Landmark Meta-Analysis of Randomized Trials. Cardiovascular Revascularization Medicine 2020, 23: 114-118. PMID: 32921597, DOI: 10.1016/j.carrev.2020.08.040.Peer-Reviewed Original ResearchConceptsUnprotected left main diseaseLeft main diseaseEXCEL trialLate mortalityCause mortalityDirection of associationRandomized trialsLate outcomesCABGLate MIMain diseaseReasonable alternativePCITrialsSignificant differencesRCTsLower ratesHigh rateMortalityYearsLong termPatientsMixed resultsPRECOMBATStrokeIncidence and clinical outcomes of bleeding complications and acute limb ischemia in STEMI and cardiogenic shock
Pahuja M, Ranka S, Chehab O, Mishra T, Akintoye E, Adegbala O, Yassin A, Ando T, Thayer K, Shah P, Kimmelstiel C, Salehi P, Kapur N. Incidence and clinical outcomes of bleeding complications and acute limb ischemia in STEMI and cardiogenic shock. Catheterization And Cardiovascular Interventions 2020, 97: 1129-1138. PMID: 32473083, PMCID: PMC8344361, DOI: 10.1002/ccd.29003.Peer-Reviewed Original ResearchConceptsST-segment elevation myocardial infarctionAcute limb ischemiaLength of stayCardiogenic shockCS-STEMIHospital mortalityVascular complicationsLimb ischemiaClinical outcomesManagement of CSPercutaneous ventricular assist deviceIntra-aortic balloon pumpPercutaneous mechanical circulatory supportRetrospective cohort studyElevation myocardial infarctionMechanical circulatory supportVentricular assist deviceU.S. national databaseTandem HeartMultiorgan failureCohort studyBalloon pumpCommon complicationMembrane oxygenationCirculatory supportTemporal trends and outcomes of patients waiting on left ventricular assist devices and inotropes for heart transplantation
Briasoulis A, Adegbala O, Akintoye E, Alvarez P. Temporal trends and outcomes of patients waiting on left ventricular assist devices and inotropes for heart transplantation. Clinical Transplantation 2020, 34: e13857. PMID: 32167606, DOI: 10.1111/ctr.13857.Peer-Reviewed Original ResearchMeSH KeywordsAdultHeart FailureHeart TransplantationHeart-Assist DevicesHumansRegistriesRetrospective StudiesTreatment OutcomeWaiting ListsConceptsLeft ventricular assist deviceRight ventricular assist deviceVentricular assist deviceOutcomes of patientsTime of listingTime of transplantationHeart transplantationAssist deviceOrgan Sharing registryTerms of survivalStatus 1AInotropic therapyLVAD recipientsUnited NetworkWorse outcomesInotropesHigh riskWaiting listPatientsTransplantationLower ratesOutcomesTemporal trendsConfoundersRegistry
2019
The impact of safety‐net burden on in‐hospital outcomes after surgical aortic valve replacement
Ando T, Adegbala O, Akintoye E, Briasoulis A, Takagi H. The impact of safety‐net burden on in‐hospital outcomes after surgical aortic valve replacement. Journal Of Cardiac Surgery 2019, 34: 1178-1184. PMID: 31441545, DOI: 10.1111/jocs.14187.Peer-Reviewed Original ResearchConceptsSurgical aortic valve replacementSafety-net burdenAortic valve replacementSAVR outcomesValve replacementAcute kidney injuryMajor perioperative complicationsHospital-level characteristicsNationwide Inpatient SampleLength of staySafety-net hospitalNumber of admissionsHospital mortalityNonroutine dischargeValvular surgeryHospital outcomesHospital stayKidney injuryPerioperative complicationsDisadvantaged patientsInpatient SampleHospital costsUnadjusted modelsHospitalPatientsClinical and economic burden of heparin-induced thrombocytopenia in hospitalized patients undergoing percutaneous peripheral arterial interventions
Subahi A, Osman M, Adegbala O, Abubakar H, Kheiri B, Yassin A, Khalid M, Akintoye E, Eljack A, Osman K, Alkhouli M. Clinical and economic burden of heparin-induced thrombocytopenia in hospitalized patients undergoing percutaneous peripheral arterial interventions. Vascular 2019, 28: 81-86. PMID: 31382836, DOI: 10.1177/1708538119868615.Peer-Reviewed Original ResearchConceptsVenous thrombosis/pulmonary embolismAcute kidney injuryKidney injuryIschemic strokePulmonary embolismHigh riskDeep venous thrombosis/pulmonary embolismPercutaneous peripheral arterial interventionsICD-9-CM codesHospital mortality differenceProlonged hospital stayHospital-level characteristicsPeripheral arterial interventionsNational Inpatient SampleHospital outcomesHospital stayIntervention patientsAbsence of heparinBaseline characteristicsHome dischargeLonger hospitalizationArterial interventionsHospitalized patientsInpatient SampleThrombocytopeniaIncidence and predictors of readmissions to non-index hospitals after transcatheter aortic valve replacement and the impact on in-hospital outcomes: From the nationwide readmission database
Ando T, Adegbala O, Villablanca P, Akintoye E, Ashraf S, Shokr M, Siddiqui F, Takagi H, Grines C, Afonso L, Briasoulis A. Incidence and predictors of readmissions to non-index hospitals after transcatheter aortic valve replacement and the impact on in-hospital outcomes: From the nationwide readmission database. International Journal Of Cardiology 2019, 292: 50-55. PMID: 31053244, DOI: 10.1016/j.ijcard.2019.04.056.Peer-Reviewed Original ResearchConceptsTranscatheter aortic valve replacementNon-index hospitalsNon-index hospital readmissionsNon-index readmissionsAortic valve replacementNationwide Readmissions DatabaseHospital mortalityIndex hospitalHospital outcomesValve replacementHospital readmissionEndovascular transcatheter aortic valve replacementMetropolitan non-teaching hospitalsMultivariable logistic regression analysisAcute kidney injuryPredictors of readmissionAcute myocardial infarctionLength of stayLogistic regression analysisNon-teaching hospitalsElective readmissionsTAVR recipientsKidney injuryPacemaker placementHealthcare utilizationCharacteristics and Outcomes of Patients With Cardiogenic Shock Utilizing Hemodialysis for Acute Kidney Injury
Adegbala O, Inampudi C, Adejumo A, Otuonye G, Akintoye E, Elsayed R, Williams K, Alvarez P, Afonso L, Briasoulis A. Characteristics and Outcomes of Patients With Cardiogenic Shock Utilizing Hemodialysis for Acute Kidney Injury. The American Journal Of Cardiology 2019, 123: 1816-1821. PMID: 30967283, DOI: 10.1016/j.amjcard.2019.02.038.Peer-Reviewed Original ResearchMeSH KeywordsAcute Kidney InjuryAgedAged, 80 and overFemaleHumansMaleMiddle AgedRenal DialysisShock, CardiogenicTreatment OutcomeConceptsLength of stayAcute kidney injuryCardiogenic shockOutcomes of patientsHospital mortalityKidney injuryTemporary mechanical supportCause of CSPropensity score-matched groupsST-elevation myocardial infarctionMechanical circulatory support devicesHigher comorbidity burdenRenal replacement therapyElevation myocardial infarctionHospital-level characteristicsRenal venous pressureNational Inpatient SampleCirculatory support devicesComorbidity burdenHospital morbidityHospital outcomesRenal functionBiventricular functionRenal perfusionVenous pressureOptimum age for performing Fontan operation in patients with univentricular heart
Akintoye E, Veldtman G, Miranda W, Connolly H, Egbe A. Optimum age for performing Fontan operation in patients with univentricular heart. Congenital Heart Disease 2019, 14: 138-139. PMID: 30945806, DOI: 10.1111/chd.12690.Peer-Reviewed Original Research
2018
Incidence, Trends, and Predictors of Palliative Care Consultation After Aortic Valve Replacement in the United States
Ando T, Adegbala O, Uemura T, Akintoye E, Ashraf S, Briasoulis A, Takagi H, Afonso L. Incidence, Trends, and Predictors of Palliative Care Consultation After Aortic Valve Replacement in the United States. Journal Of Palliative Care 2018, 34: 111-117. PMID: 30587081, DOI: 10.1177/0825859718819433.Peer-Reviewed Original ResearchConceptsSurgical aortic valve replacementTranscatheter aortic valve replacementAortic valve replacementPC referral rateAdjusted odds ratioPC consultPC referralValve replacementIndex hospitalizationPC consultationReferral ratesTransapical transcatheter aortic valve replacementAortic valve replacement patientsNationwide Inpatient Sample databaseValve replacement patientsPalliative care consultPalliative care consultationMultivariable regression analysisCare consultTAVR cohortAcceptable morbidityInpatient mortalityReplacement patientsElectrolyte derangementsNIS databaseClinical Impact of Diabetes Mellitus on Short-Term Outcomes andIn-Hospital Mortality of Cardiac Mechanical Support with Left Ventricular Assist Device (LVAD): A Retrospective Study from a National Database
Yassin A, Subahi A, Adegbala O, Abubakar H, Akintoye E, Ahmed A, Ismail A, Elhag A, Kambal A, Alade A, Shokr M, Weinberger J, Levine D, Afonso L. Clinical Impact of Diabetes Mellitus on Short-Term Outcomes andIn-Hospital Mortality of Cardiac Mechanical Support with Left Ventricular Assist Device (LVAD): A Retrospective Study from a National Database. Cardiovascular Revascularization Medicine 2018, 20: 883-886. PMID: 30578171, DOI: 10.1016/j.carrev.2018.12.011.Peer-Reviewed Original ResearchMeSH KeywordsAdultAgedDatabases, FactualDiabetes MellitusFemaleHeart FailureHeart-Assist DevicesHospital MortalityHumansMaleMiddle AgedProsthesis DesignProsthesis ImplantationRecovery of FunctionRegistriesRetrospective StudiesRisk AssessmentRisk FactorsTime FactorsTreatment OutcomeUnited StatesVentricular Dysfunction, LeftVentricular Function, LeftConceptsLeft ventricular assist deviceCardiac mechanical supportDiabetes mellitusCost of hospitalizationCardiac supportVentricular assist deviceHospital mortalityDiabetic patientsHeart failureClinical impactMultivariable logistic regression model analysisAssist deviceStage D heart failureAdvanced congestive heart failureNational Inpatient Sample databasePost-LVAD complicationsShort-term complicationsCongestive heart failureLogistic regression model analysisHospital-level characteristicsImpact of diabetesRegression model analysisInpatient mortalityLVAD implantationSecondary outcomesIn‐hospital outcomes of transcatheter mitral valve repair with Mitraclip in patients with pulmonary hypertension: Insights from the National Inpatient Sample
Ahmed A, Akintoye E, Adegbala O, Yassin A, Subahi A, Bangura L, Abubakar H, Elder M, Shokr M, Afonso L. In‐hospital outcomes of transcatheter mitral valve repair with Mitraclip in patients with pulmonary hypertension: Insights from the National Inpatient Sample. Catheterization And Cardiovascular Interventions 2018, 94: e30-e36. PMID: 30506974, DOI: 10.1002/ccd.27997.Peer-Reviewed Original ResearchMeSH KeywordsAgedAged, 80 and overCardiac CatheterizationClinical Decision-MakingDatabases, FactualFemaleHeart Valve ProsthesisHeart Valve Prosthesis ImplantationHospital MortalityHumansHypertension, PulmonaryMaleMiddle AgedMitral ValveMitral Valve InsufficiencyPatient SelectionPostoperative ComplicationsPrevalenceProsthesis DesignRecovery of FunctionRetrospective StudiesRisk AssessmentRisk FactorsTime FactorsTreatment OutcomeUnited StatesConceptsTranscatheter mitral valve repairNational Inpatient SamplePulmonary hypertensionMitral valve repairHospital outcomesValve repairInpatient SamplePre-existing pulmonary hypertensionPrevalence of PHPostoperative deep vein thrombosisAcute respiratory failureCohort of patientsDeep vein thrombosisMedian hospital costsHemorrhage requiring transfusionLength of stayPH groupCardiogenic shockPostoperative sepsisRespiratory failureHome dischargeInpatient mortalityPeriprocedural outcomesProhibitive riskPulmonary embolismThe impact of atrial fibrillation on transcatheter mitral valve repair outcomes: A propensity‐matched analysis
Subahi A, Munir A, Abubakar H, Akintoye E, Yassin A, Adegbala O, Alraies M, Elder M, Mohamad T, Kaki A, Schreiber T. The impact of atrial fibrillation on transcatheter mitral valve repair outcomes: A propensity‐matched analysis. Journal Of Interventional Cardiology 2018, 31: 925-931. PMID: 30456770, DOI: 10.1111/joic.12568.Peer-Reviewed Original ResearchConceptsTranscatheter mitral valve repairAtrial fibrillationHospital outcomesTranscatheter Mitral Valve Repair OutcomesICD-9-CM diagnostic codesMitral valve repair outcomesNational Inpatient Sample registryNon-routine hospital dischargeImpact of AFPrevalence of AFPropensity score-matched analysisHigher AF burdenPropensity-matched analysisRepresentative United States sampleHospital-level characteristicsMitral valve repairCost of hospitalizationLength of stayHospital mortalityAF burdenHospital dischargePatient characteristicsAF patientsBaseline rhythmTMVR proceduresVenous congestion and pulmonary vascular function in Fontan circulation: Implications for prognosis and treatment
Egbe A, Reddy Y, Khan A, Al-Otaibi M, Akintoye E, Obokata M, Borlaug B. Venous congestion and pulmonary vascular function in Fontan circulation: Implications for prognosis and treatment. International Journal Of Cardiology 2018, 271: 312-316. PMID: 30223363, PMCID: PMC6146405, DOI: 10.1016/j.ijcard.2018.05.039.Peer-Reviewed Original ResearchConceptsPulmonary vascular resistance indexCentral venous pressureSystemic venous congestionPulmonary vascular functionFontan patientsVenous congestionFontan circulationVascular functionElevated pulmonary vascular resistance indexAdult Fontan patientsVascular resistance indexPulmonary blood flowSub-pulmonary ventricleCongenital heart diseaseLow-level elevationsPulmonary vascular structureFontan groupFontan populationAntiplatelet therapyCause mortalityCardiac catheterizationComposite endpointVenous pressureMulticenter studyAdverse outcomesClinical impact of advanced chronic kidney disease on outcomes and in-hospital complications of Takotsubo Syndrome (broken-heart-syndrome): Propensity-matched national study
Yassin A, Adegbala O, Subahi A, Abubakar H, Akintoye E, Abdelrahamn M, Ahmed A, Agarwal A, Shokr M, Pahuja M, Elder M, Kaki A, Schreiber T, Mohamad T. Clinical impact of advanced chronic kidney disease on outcomes and in-hospital complications of Takotsubo Syndrome (broken-heart-syndrome): Propensity-matched national study. International Journal Of Cardiology 2018, 277: 16-19. PMID: 30293663, DOI: 10.1016/j.ijcard.2018.09.098.Peer-Reviewed Original ResearchConceptsAdvanced chronic kidney diseaseChronic kidney diseaseAcute kidney injuryTakotsubo syndromeHospital complicationsKidney diseaseCKD groupImpact of CKDNational Inpatient Sample databasePropensity score-matched analysisAdvanced CKD groupAdvanced CKD patientsIn-Hospital MortalityCost of hospitalizationCKD patientsHospital mortalityHospital lengthHospital stayKidney injuryComplication rateInpatient mortalitySecondary outcomesTakotsubo cardiomyopathyPrimary outcomeClinical outcomesIncidence, Predictors, and In-Hospital Outcomes of Transcatheter Aortic Valve Implantation After Nonelective Admission in Comparison With Elective Admission: From the Nationwide Inpatient Sample Database
Ando T, Adegbala O, Villablanca P, Akintoye E, Ashraf S, Shokr M, Briasoulis A, Takagi H, Grines C, Afonso L, Schreiber T. Incidence, Predictors, and In-Hospital Outcomes of Transcatheter Aortic Valve Implantation After Nonelective Admission in Comparison With Elective Admission: From the Nationwide Inpatient Sample Database. The American Journal Of Cardiology 2018, 123: 100-107. PMID: 30360892, DOI: 10.1016/j.amjcard.2018.09.023.Peer-Reviewed Original ResearchConceptsTranscatheter aortic valve implantationNationwide Inpatient Sample databaseNonelective admissionsPropensity-matched cohortAortic valve implantationHospital mortalityValve implantationElective admissionsOutcomes of TAVITransarterial transcatheter aortic valve implantationSample databaseHigher adverse outcomesPulmonary circulation disordersAcute kidney injuryHealth resource utilizationIn-Hospital OutcomesChronic kidney diseaseIndependent risk factorCongestive heart failureHigh-risk cohortAcute myocardial infarctionCardiogenic shockHospital lengthKidney injuryRespiratory failureIncidence and outcomes of cardiac tamponade in patients undergoing cardiac resynchronization therapy
Adegbala O, Olagoke O, Adejumo A, Akintoye E, Oluwole A, Alebna P, Williams K, Lieberman R, Afonso L. Incidence and outcomes of cardiac tamponade in patients undergoing cardiac resynchronization therapy. International Journal Of Cardiology 2018, 272: 137-141. PMID: 30045818, DOI: 10.1016/j.ijcard.2018.07.084.Peer-Reviewed Original ResearchConceptsNationwide Inpatient SampleCRT implantationCardiac tamponadeCoagulation disordersCardiac resynchronization therapy implantationHierarchical mixed-effects logistic regression modelsDevelopment of tamponadePropensity-matched analysisCardiac resynchronization therapyMixed effects logistic regression modelsLogistic regression modelsHospital mortalityHospital stayMultivariable adjustmentCABG proceduresHospitalized patientsIndependent predictorsResynchronization therapySevere complicationsRisk stratificationFemale sexInpatient SampleFemale genderHigher oddsPrior historyComparison of Hospital Outcomes of Transcatheter AorticValve Implantation With Versus Without Hypothyroidism
Subahi A, Yassin A, Adegbala O, Akintoye E, Abubakar H, Elmoghrabi A, Ibrahim W, Ajam M, Pahuja M, Weinberger J, Levine D, Afonso L. Comparison of Hospital Outcomes of Transcatheter AorticValve Implantation With Versus Without Hypothyroidism. The American Journal Of Cardiology 2018, 122: 838-843. PMID: 30037424, DOI: 10.1016/j.amjcard.2018.05.025.Peer-Reviewed Original ResearchConceptsTranscatheter aortic valve implantationHypothyroid patientsImpact of hypothyroidismHospital outcomesSevere symptomatic aortic stenosisNational Inpatient Sample databasePropensity score-matched analysisSymptomatic aortic stenosisAdditional randomized trialsAortic valve implantationCost of hospitalizationHemorrhage requiring transfusionEffect of hypothyroidismHospital mortalityTAVR outcomesHospital stayInpatient mortalityPostprocedural complicationsSecondary outcomesValve implantationAortic stenosisBlood transfusionPrimary outcomeClinical outcomesRandomized trials