Polygenic Risk of Epilepsy and Poststroke Epilepsy
Clocchiatti-Tuozzo S, Rivier C, Misra S, Zelano J, Mazumder R, Sansing L, de Havenon A, Hirsch L, Liebeskind D, Gilmore E, Sheth K, Kim J, Worrall B, Falcone G, Mishra N. Polygenic Risk of Epilepsy and Poststroke Epilepsy. Stroke 2024, 55: 2835-2843. PMID: 39502073, DOI: 10.1161/strokeaha.124.047459.Peer-Reviewed Original ResearchParticipants of European ancestryRisk of poststroke epilepsyPolygenic riskPoststroke epilepsyEuropean ancestryGenome-wide association study meta-analysisPRS decileCase-control genetic association studyGenetic risk lociLowest decilePolygenic risk scoresGenetic association studiesMultivariate logistic regression modelStudy meta-analysisMultivariate logistic regression resultsHistory of strokeLogistic regression modelsRisk lociAssociation studiesStroke survivorsUK BiobankGenetic informationGenetic ancestryLogistic regression resultsGenetic variantsTemperature Control Parameters Are Important: Earlier Preinduction Is Associated With Improved Outcomes Following Out-of-Hospital Cardiac Arrest
Beekman R, Kim N, Nguyen C, McGinniss G, Deng Y, Kitlen E, Garcia G, Wira C, Khosla A, Johnson J, Miller P, Perman S, Sheth K, Greer D, Gilmore E. Temperature Control Parameters Are Important: Earlier Preinduction Is Associated With Improved Outcomes Following Out-of-Hospital Cardiac Arrest. Annals Of Emergency Medicine 2024, 84: 549-559. PMID: 39033449, DOI: 10.1016/j.annemergmed.2024.06.007.Peer-Reviewed Original ResearchOut-of-hospital cardiac arrestNeurological outcomeDevice cohortCardiac arrestOut-of-hospital cardiac arrest patientsConsecutive out-of-hospital cardiac arrestPreinduction timeInterquartile rangeAssociated with improved outcomesCardiac arrest patientsProportion of patientsMultivariate logistic regression modelInverse probability of treatmentDevice timeInverse probability treatment weightsProbability of treatmentProspective trialsOHCA patientsArrest patientsClinical outcomesLogistic regression modelsCenter studyEarly initiationSecondary outcomesTreatment weighting13 Prognostication in super refractory status epilepticus: Preliminary results from an international survey study
Woodward M, Brown J, Badjatia N, Morris N, Johnson E, Gilmore E. 13 Prognostication in super refractory status epilepticus: Preliminary results from an international survey study. Journal Of Clinical And Translational Science 2024, 8: 4-4. PMCID: PMC11023845, DOI: 10.1017/cts.2024.34.Peer-Reviewed Original ResearchHealth care providersWithdrawal of life-sustaining therapySuper-refractory status epilepticusHCP responsesAdvanced practice providersPerceived poor neurologic prognosisLife-sustaining therapyCountry of practiceTreating super-refractory status epilepticusHypothetical clinical casesRefractory status epilepticusLogistic regression modelsPractice providersCare providersSurveyed cliniciansCare escalationYears of experienceClinician-specific factorsMedical futilityPotential confoundersPoor neurologic prognosisRespondent demographicsStatus epilepticusInternational survey studyAssociated with high mortality