Emanuela Bruscia, PhD
Associate Professor of Pediatrics (Respiratory)DownloadHi-Res Photo
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Pediatric Pulmonology, Allergy, Immunology & Sleep Medicine
PO Box 208064
New Haven, CT 06520-8064
United States
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Associate Professor of Pediatrics (Respiratory)
Biography
Dr. Bruscia received her Ph.D. in Biochemistry and Molecular Genetics from the University of Tor Vergata in Rome (Italy) in 2002. Since she was an undergraduate, her research has been dedicated to Cystic Fibrosis. During her undergraduate studies, she began working in the exciting field of gene therapy. She spent two years in the laboratory of Dr. Dieter Gruenert at the University of Vermont (Burlington, VT), where she worked on non-viral gene therapy strategies. She started her postdoctoral training in the laboratory of Dr. Diane Krause at Yale School of Medicine in 2002. Here, she explored the use of bone marrow-derived cells as a vehicle for gene therapy in the airway and intestinal epithelia in murine models for CF. In 2005, Dr. Bruscia was appointed as an Associate Research Scientist in the Department of Pediatrics at Yale School of Medicine and in 2010 promoted as an Assistant Professor in the same department. In 2016, she was promoted to Associate Professor. In the past ten years, her research interest has focused on the role of CFTR in the immune system, particularly in macrophages. The current focus of her lab is to explore emerging therapeutic strategies able to target several aspects of CF lung disease, while still proceeding with studies focused on understanding how the lack of CFTR is impairing macrophage function.
Last Updated on April 07, 2025.
Appointments
Pediatric Pulmonology, Allergy, Immunology & Sleep Medicine
Associate Professor on TermPrimary
Other Departments & Organizations
- Bruscia Lab
- Center for Infection and Immunity
- CPIRT - Center for Pulmonary Injury, Inflammation, Repair and Therapeutics
- Molecular Medicine, Pharmacology, and Physiology
- Pediatric Pulmonology, Allergy, Immunology & Sleep Medicine
- Pediatrics
- Program in Translational Biomedicine (PTB)
- Yale Combined Program in the Biological and Biomedical Sciences (BBS)
- Yale Stem Cell Center
- Yale Ventures
- YCCEH
Education & Training
- PhD
- Tor Vergata University in Rome (2002)
Research
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Overview
Medical Research Interests
Cystic Fibrosis; Cystic Fibrosis Transmembrane Conductance Regulator; Lung; Macrophages; Pediatrics; Respiration Disorders
ORCID
0000-0003-2149-4057- View Lab Website
Bruscia Lab
Research at a Glance
Yale Co-Authors
Frequent collaborators of Emanuela Bruscia's published research.
Publications Timeline
A big-picture view of Emanuela Bruscia's research output by year.
Research Interests
Research topics Emanuela Bruscia is interested in exploring.
Marie Egan, MD
Diane Krause, MD, PhD
Thomas Murray, MD, PhD
Ping-Xia Zhang, MD, PhD
Stephanie Halene, MD, Dr Med
Giulia Biancon, PhD
78Publications
3,198Citations
Cystic Fibrosis
Cystic Fibrosis Transmembrane Conductance Regulator
Lung
Macrophages
Publications
2025
Dysregulated alveolar type 2 epithelial cell proteostasis promotes fibrogenic macrophage migration inhibitory factor–CD74 signaling
Kim S, Nouws J, Ruwisch J, Woodard G, Cooley J, Khoury J, Sun H, Doherty E, Piecychna M, Manning E, Kang M, Bruscia E, Wei H, Zhang Y, Yarovinsky T, Hwa J, Zacharias W, Ingram J, Lee C, Elias J, Kaminski N, Redente E, Herzog E, Prasse A, Bucala R, Sauler M. Dysregulated alveolar type 2 epithelial cell proteostasis promotes fibrogenic macrophage migration inhibitory factor–CD74 signaling. Science Translational Medicine 2025, 17: eadr2277. PMID: 41337540, DOI: 10.1126/scitranslmed.adr2277.Peer-Reviewed Original ResearchAltmetricMeSH Keywords and ConceptsMeSH KeywordsAlveolar Epithelial CellsAnimalsAntigens, Differentiation, B-LymphocyteBleomycinDisease Models, AnimalHistocompatibility Antigens Class IIHumansIdiopathic Pulmonary FibrosisIntramolecular OxidoreductasesLungMacrophage Migration-Inhibitory FactorsMacrophagesMaleMiceMice, Inbred C57BLMice, TransgenicProteasome Endopeptidase ComplexProteostasisSignal TransductionUbiquitinConceptsIdiopathic pulmonary fibrosisMacrophage migration inhibitory factorBronchoalveolar lavage fluidPharmacological inhibition of MIFBleomycin-induced lung injury modelMouse modelPharmacological inhibitionC-X3-C motif chemokine receptor 1Human precision-cut lung slicesTransforming growth factor-b1Inhibition of macrophage migration inhibitory factorSignals to macrophagesPrecision-cut lung slicesFibrotic lung diseaseType 2 epithelial cellsAlveolar type 2 epithelial cellsChemokine receptor 1Lung injury modelMigration inhibitory factorMIF-2Study participantsUbiquitin-proteasome systemSpontaneous fibrosisPulmonary fibrosisLavage fluidEditorial: The heme oxygenase system in immunity
Costa D, Bruscia E, Willis D. Editorial: The heme oxygenase system in immunity. Frontiers In Immunology 2025, 16: 1740080. PMID: 41346632, PMCID: PMC12672320, DOI: 10.3389/fimmu.2025.1740080.Peer-Reviewed Original ResearchChronic pulmonary LPS exposure in cystic fibrosis drives maladaptive pro-inflammatory hematopoietic stem and progenitor cells
Isler Mancuso R, Thompson E, Braga C, Oez H, Gudneppanavar R, Zhang P, Neves T, Krause W, Huang P, Murray T, Egan M, Bruscia E, Krause D. Chronic pulmonary LPS exposure in cystic fibrosis drives maladaptive pro-inflammatory hematopoietic stem and progenitor cells. Blood 2025, 146: 3175-3175. DOI: 10.1182/blood-2025-3175.Peer-Reviewed Original ResearchConceptsGranulocyte-monocyte progenitorsCF miceCystic fibrosisBone marrowLT-HSCLT-HSCsHematopoietic stemLung inflammationMyeloid cellsProgenitor cellsTNF-aLong-term hematopoietic stem cellsLPS exposureWild-typeMulti-potent progenitorsMyeloid differentiationEpigenetic reprogrammingChronic inflammatory signalingLong-term HSCsWT mouse lungsHematopoietic stem cellsMonths post-transplantMouse peripheral bloodPersistent lung inflammationChronic inflammatory stimulus253 An electrochemiluminescence immunoassay to quantify CFTR protein across species
Browne J, Garrison A, Lee J, Gudneppanavar R, Bruscia E, Egan M. 253 An electrochemiluminescence immunoassay to quantify CFTR protein across species. Journal Of Cystic Fibrosis 2025, 24: s146. DOI: 10.1016/s1569-1993(25)01872-7.Peer-Reviewed Original Research194 Restoration of ezrin via calpain inhibition reinstates immune function in cystic fibrosis alveolar macrophages
Gudneppanavar R, Essayas H, Braga C, Garrison A, Zhang P, Huang P, da Silva Neves T, Britto C, Egan M, Murray T, Bruscia E. 194 Restoration of ezrin via calpain inhibition reinstates immune function in cystic fibrosis alveolar macrophages. Journal Of Cystic Fibrosis 2025, 24: s111a-s111. DOI: 10.1016/s1569-1993(25)01813-2.Peer-Reviewed Original Research182 ETI treatment modulates IFN signaling in airway immune cells from children with cystic fibrosis
Kizilirmak T, Knight C, Yin H, Garrison A, Browne J, Bruscia E, Egan M, Britto C. 182 ETI treatment modulates IFN signaling in airway immune cells from children with cystic fibrosis. Journal Of Cystic Fibrosis 2025, 24: s105. DOI: 10.1016/s1569-1993(25)01801-6.Peer-Reviewed Original Research197 Reduced levels of active hepatocyte growth factor correlate with lung damage in a CF mouse model
Krause W, da Silva Neves T, Braga C, Gudneppanavar R, Knight C, Britto C, Egan M, Murray T, Bruscia E. 197 Reduced levels of active hepatocyte growth factor correlate with lung damage in a CF mouse model. Journal Of Cystic Fibrosis 2025, 24: s113. DOI: 10.1016/s1569-1993(25)01816-8.Peer-Reviewed Original Research365 Chronic lung inflammation in cystic fibrosis drives maladaptive trained Tmmunity in hematopoietic stem cells
Braga C, Mancuso R, Thompson E, Oez H, Gudneppanavar R, Zhang P, da Silva Neves T, Huang P, Krause W, Murray T, Egan M, Krause D, Bruscia E. 365 Chronic lung inflammation in cystic fibrosis drives maladaptive trained Tmmunity in hematopoietic stem cells. Journal Of Cystic Fibrosis 2025, 24: s201. DOI: 10.1016/s1569-1993(25)01983-6.Peer-Reviewed Original Research362 Dramatic shifts in resident immune cell populations accompany CF mouse ileum remodeling during development
Streater R, Cao Y, Muiler C, Oez H, Santiago E, Krause W, Garrison A, Egan M, Konnikova L, Ameen N, Bruscia E. 362 Dramatic shifts in resident immune cell populations accompany CF mouse ileum remodeling during development. Journal Of Cystic Fibrosis 2025, 24: s199a-s200. DOI: 10.1016/s1569-1993(25)01980-0.Peer-Reviewed Original Research244 Restoration of in vivo CFTR function by tracheal basal cell engraftment
Berical A, Chen K, Oez H, Dunphy V, Gudneppanavar R, Braga C, Garrison A, Egan M, Kotton D, Bruscia E, Hawkins F. 244 Restoration of in vivo CFTR function by tracheal basal cell engraftment. Journal Of Cystic Fibrosis 2025, 24: s140. DOI: 10.1016/s1569-1993(25)01863-6.Peer-Reviewed Original Research
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- We investigate the mechanism/s by which the dysregulated activity of immune cells contributes to the overwhelming lung inflammation, the weakened host defense against certain microorganisms, and the altered lung tissue repair processes that characterize CF lung disease.
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Pediatric Pulmonology, Allergy, Immunology & Sleep Medicine
PO Box 208064
New Haven, CT 06520-8064
United States