Divergent T follicular helper cell requirement for IgA and IgE production to peanut during allergic sensitization
Zhang B, Liu E, Gertie JA, Joseph J, Xu L, Pinker EY, Waizman DA, Catanzaro J, Hamza KH, Lahl K, Gowthaman U, Eisenbarth SC. Divergent T follicular helper cell requirement for IgA and IgE production to peanut during allergic sensitization. Science Immunology 2020, 5 PMID: 32385053, PMCID: PMC8518330, DOI: 10.1126/sciimmunol.aay2754.Peer-Reviewed Original ResearchConceptsFood antigensIgE productionIgA productionFollicular helper cellsMinority of miceHelper cell requirementDominant antibody isotypeCross-reactive IgAFollicular regulatoryDietary antigensAllergic sensitizationTolerogenic responsesMucosal adjuvantMucosal IgAHelper cellsAntibody isotypesStool samplesImmunoglobulin AT cellsFood exposureGerminal centersFood allergensAntibody productionIgADietary exposure