2018
Pharmacological and Behavioral Treatment of Opioid Use Disorder
Sofuoglu M, DeVito E, Carroll K. Pharmacological and Behavioral Treatment of Opioid Use Disorder. Psychiatric Research And Clinical Practice 2018, 1: 4-15. PMCID: PMC9175946, DOI: 10.1176/appi.prcp.20180006.Peer-Reviewed Original ResearchOpioid use disorderMedication-assisted treatmentSubstance use conditionsBehavioral treatmentTreatment retentionUse disordersBehavioral interventionsOpioid withdrawal symptomsFirst-line treatmentMechanism of actionOUD treatmentComorbid conditionsMedication complianceWithdrawal symptomsClinical overviewClinical guidelinesOpioid receptorsAdrenergic agonistsNonsystematic reviewDrug AdministrationKey pharmacologicalBehavioral therapyTreatment effectivenessComplex needsTreatmentfMRI Stroop and behavioral treatment for cocaine-dependence: Preliminary findings in methadone-maintained individuals
DeVito EE, Kober H, Carroll KM, Potenza MN. fMRI Stroop and behavioral treatment for cocaine-dependence: Preliminary findings in methadone-maintained individuals. Addictive Behaviors 2018, 89: 10-14. PMID: 30240978, PMCID: PMC6374034, DOI: 10.1016/j.addbeh.2018.09.005.Peer-Reviewed Original ResearchConceptsCocaine use disorderStroop effectBehavioral treatmentComputer-based cognitive behavioral therapyColor-word Stroop taskCognitive neuroscience methodsCognitive behavioral therapyCocaine-dependent individualsCocaine abstinenceCognitive controlStroop taskNeuroscience methodsMethadone-maintained individualsTreatment abstinenceLingual gyrusStroopCingulate gyrusUse disordersCocaine usersTreatment mechanismsAbstinenceBetter treatment outcomesPreliminary findingsGyrusParticipants
2017
Atomoxetine in abstinent cocaine users: Cognitive, subjective and cardiovascular effects
DeVito EE, Herman AI, Konkus NS, Zhang H, Sofuoglu M. Atomoxetine in abstinent cocaine users: Cognitive, subjective and cardiovascular effects. Pharmacology Biochemistry And Behavior 2017, 159: 55-61. PMID: 28716656, PMCID: PMC5573182, DOI: 10.1016/j.pbb.2017.07.002.Peer-Reviewed Original ResearchMeSH KeywordsAdrenergic Uptake InhibitorsAdultAffectAtomoxetine HydrochlorideAttentionCocaine-Related DisordersCognitionCross-Over StudiesDose-Response Relationship, DrugDouble-Blind MethodFemaleHemodynamicsHumansInhibition, PsychologicalMaleMemory, Short-TermMiddle AgedNeuropsychological TestsSex CharacteristicsConceptsCocaine use disorderMeasures of attentionAbstinent cocaine usersSubjective drug effectsHuman laboratory studiesResponse inhibitionCognitive enhancementAbstinent individualsCognitive enhancersBehavioral treatmentAddictive processClinical populationsAtomoxetineCognitive impairmentNorepinephrine transporter inhibitorUse disordersCocaine usersCardiovascular effectsMoodMedication effectsPoor clinical outcomeDose-dependent effectIndividualsDrug effectsMemory
2016
Cognitive Function as a Transdiagnostic Treatment Target in Stimulant Use Disorders
Sofuoglu M, DeVito EE, Waters AJ, Carroll KM. Cognitive Function as a Transdiagnostic Treatment Target in Stimulant Use Disorders. Journal Of Dual Diagnosis 2016, 12: 90-106. PMID: 26828702, PMCID: PMC4837011, DOI: 10.1080/15504263.2016.1146383.Peer-Reviewed Original ResearchConceptsStimulant use disorderTransdiagnostic treatment targetExecutive controlAutomatic processCognitive impairmentUse disordersAddictive behaviorsCognitive functionDual-process modelCognitive behavioral therapyMaintenance of addictionCertain cognitive impairmentsPoor treatment retentionTreatment targetsAttentional biasApproach biasCognitive rehabilitationResponse inhibitionCognitive enhancementSustained attentionBehavioral therapyBehavioral treatmentAnxiety disordersBehavioral approachRates of lifetime
2014
Gender differences in clinical outcomes for cocaine dependence: Randomized clinical trials of behavioral therapy and disulfiram
DeVito EE, Babuscio TA, Nich C, Ball SA, Carroll KM. Gender differences in clinical outcomes for cocaine dependence: Randomized clinical trials of behavioral therapy and disulfiram. Drug And Alcohol Dependence 2014, 145: 156-167. PMID: 25457739, PMCID: PMC4268325, DOI: 10.1016/j.drugalcdep.2014.10.007.Peer-Reviewed Original ResearchConceptsRandomized clinical trialsClinical trialsClinical outcomesTreatment outcomesCocaine dependenceBehavioral therapyBehavioral treatment conditionsPoor treatment outcomesEvidence-based treatmentsGender differencesWidespread clinical implementationPoor outcomePharmacological treatmentMedication conditionAddiction pharmacotherapyCocaine useSecondary analysisBehavioral treatmentClinical implementationWomenCareful assessmentDisulfiramOutcomesTrialsMenPretreatment measures of brain structure and reward-processing brain function in cannabis dependence: An exploratory study of relationships with abstinence during behavioral treatment 1
Yip SW, DeVito EE, Kober H, Worhunsky PD, Carroll KM, Potenza MN. Pretreatment measures of brain structure and reward-processing brain function in cannabis dependence: An exploratory study of relationships with abstinence during behavioral treatment 1. Drug And Alcohol Dependence 2014, 140: 33-41. PMID: 24793365, PMCID: PMC4057888, DOI: 10.1016/j.drugalcdep.2014.03.031.Peer-Reviewed Original ResearchConceptsCannabis-dependent participantsMagnetic resonance imagingCannabis dependenceHC participantsTreatment responseConsecutive abstinenceHealthy comparison menBilateral putamen volumesCannabis-dependent individualsSuccessful treatment outcomeEfficacy of therapeuticsDays of abstinenceVentral striatal activationClinical trialsStriatal functionTreatment outcomesMRI scanningComparison menPutamen volumeResonance imagingBehavioral treatmentBiological markersBrain functionBrain structuresAbstinence
2012
Cognitive enhancement as a treatment for drug addictions
Sofuoglu M, DeVito EE, Waters AJ, Carroll KM. Cognitive enhancement as a treatment for drug addictions. Neuropharmacology 2012, 64: 452-463. PMID: 22735770, PMCID: PMC3445733, DOI: 10.1016/j.neuropharm.2012.06.021.Peer-Reviewed Original ResearchConceptsCognitive enhancementBehavioral interventionsExecutive inhibitory controlCognitive impairmentDrug addictionSelective cognitive functionsCurrent illicit drug usersPoor treatment retentionCognitive enhancing agentsSignificant cognitive impairmentSpecific behavioral interventionsChronic drug useCognitive remediationInhibitory controlMarijuana addictionCognitive enhancersBehavioral treatmentCognitive functionDrug use behaviorsMultiple addictionsSubstance usersTreatment retentionInhibition functionFuture researchUse behaviors