2024
Inflammatory Response and Defects on Myelin Integrity in the Olfactory System of K18hACE2 Mice Infected with SARS-CoV-2
Martin-Lopez E, Brennan B, Mao T, Spence N, Meller S, Han K, Yahiaoui N, Wang C, Iwasaki A, Greer C. Inflammatory Response and Defects on Myelin Integrity in the Olfactory System of K18hACE2 Mice Infected with SARS-CoV-2. ENeuro 2024, 11: eneuro.0106-24.2024. PMID: 38834299, PMCID: PMC11185043, DOI: 10.1523/eneuro.0106-24.2024.Peer-Reviewed Original ResearchOlfactory bulbOlfactory epitheliumPiriform cortexOlfactory tractOlfactory systemSARS-CoV-2Projection neuronsMyelination defectsOlfactory sensory neuronsLateral olfactory tractLoss of olfactionRespiratory epithelial cellsLamina propria macrophagesSARS-CoV-2 infectionInfected SCDays of infectionIntegrity of myelinOlfactory dysfunctionInfected microgliaSensitive to infectionOlfactory deficitsSensory neuronsSustentacular cellsNasal cavityNeuronal conduction
2023
α-Synuclein Pathology and Reduced Neurogenesis in the Olfactory System Affect Olfaction in a Mouse Model of Parkinson's Disease
Martin-Lopez E, Vidyadhara D, Liberia T, Meller S, Harmon L, Hsu R, Spence N, Brennan B, Han K, Yücel B, Chandra S, Greer C. α-Synuclein Pathology and Reduced Neurogenesis in the Olfactory System Affect Olfaction in a Mouse Model of Parkinson's Disease. Journal Of Neuroscience 2023, 43: 1051-1071. PMID: 36596700, PMCID: PMC9908323, DOI: 10.1523/jneurosci.1526-22.2022.Peer-Reviewed Original ResearchConceptsΑ-syn tg miceΑ-Syn pathologyOlfactory bulb neurogenesisProjection neuronsParkinson's diseaseOlfactory dysfunctionMutant α-synucleinOlfactory deficitsOlfactory pathwaySyn pathologyBehavioral deficitsMouse modelΑ-synucleinOB granule cellsΑ-synuclein pathologyOlfactory systemMonths of ageReduced neurogenesisFunctional deficitsPeriglomerular cellsMotor progressionPathologic changesMultiple symptomsSynaptic terminalsGranule cells
2019
Embryonic and postnatal development of mouse olfactory tubercle
Martin-Lopez E, Xu C, Liberia T, Meller SJ, Greer CA. Embryonic and postnatal development of mouse olfactory tubercle. Molecular And Cellular Neuroscience 2019, 98: 82-96. PMID: 31200100, DOI: 10.1016/j.mcn.2019.06.002.Peer-Reviewed Original ResearchConceptsOlfactory tubercleVentral striatumOlfactory bulb projection neuronsPrimary afferent inputTyrosine hydroxylase expressionLateral ganglionic eminenceDopamine reward systemCNPase stainingVentral medial regionDopaminergic innervationProjection neuronsStriatal neuronsVentral tegmentumAfferent inputDopaminergic inputLaminar distributionMedial gradientHydroxylase expressionNucleus accumbensGanglionic eminencePostnatal developmentE11-E15OT cellsVentral lateral ganglionic eminencePostnatal stages
2011
Dab1 (Disable Homolog-1) Reelin Adaptor Protein Is Overexpressed in the Olfactory Bulb at Early Postnatal Stages
Martín-López E, Blanchart A, De Carlos JA, López-Mascaraque L. Dab1 (Disable Homolog-1) Reelin Adaptor Protein Is Overexpressed in the Olfactory Bulb at Early Postnatal Stages. PLOS ONE 2011, 6: e26673. PMID: 22046330, PMCID: PMC3201967, DOI: 10.1371/journal.pone.0026673.Peer-Reviewed Original ResearchConceptsWild-type miceOlfactory bulb layersEarly postnatal stagesDab1 expressionEarly brain developmentProjection neuronsReeler miceOlfactory bulbType miceBrain developmentPostnatal stagesProtein expressionBulb layersExpression levelsDab1MiceNeuronsReelin effectsPresent studyReelerRELNCritical rolePossible regulationApparent differencesAdaptor protein